The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Smoking, alcohol, and coffee consumption preceding Parkinson’s disease: A case-control study
Abstract
OBJECTIVE: To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS: The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995. Each incident case was matched by age (+/-1 year) and sex to a general population control subject. The authors reviewed the complete medical records of cases and control subjects to abstract exposure information. RESULTS: For coffee consumption, the authors found an OR of 0.35 (95% CI = 0.16 to 0.78, p = 0.01), a dose-effect trend (p = 0.003), and a later age at PD onset in cases who drank coffee compared with those who never did (median 72 versus 64 years; p = 0.0002). The inverse association with coffee remained significant after adjustment for education, smoking, and alcohol drinking and was restricted to PD cases with onset at age <72 years and to men. The OR for cigarette smoking was 0.69 (95% CI = 0.45 to 1.08, p = 0.1). The authors found no association between PD and alcohol consumption. Extreme or unusual behaviors such as tobacco chewing or snuff use and a diagnosis of alcoholism were significantly more common in control subjects than cases. CONCLUSIONS: These findings suggest an inverse association between coffee drinking and PD; however, this association does not imply that coffee has a direct protective effect against PD. Alternative explanations for the association should be considered.
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“Caffeine overdose can delay sleep onset, reduce total sleep time, change normal sleep stages, and reduce sleep quality. Caffeine-induced sleep disorder is known as a psychiatric disorder caused by excessive caffeine consumption [120].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [120]
In the citing paper
“Excessive caffeine can cause symptoms ranging from general anxiety to compulsive disorders [120].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [120]
Citations
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Cited by
Sorted by citations
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
Epidemiology and etiology of Parkinson's disease: a review of the evidence
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“Although many of the case-control studies reported ORs below unity, the association was non-significant in most studies [142, 143, 293, 298, 303, 309, 310, 380, 407, 408, 410, 413, 415, 423].”
ResultInfluentialA meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
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Prospective Study of Caffeine Consumption and Risk of Parkinson’s Disease in Men and Women
Ascherio, A., Zhang, S. M., Hernán, M. A., Kawachi, I., Colditz, G. A., Speizer, F. E., & Willett, W. C. (2001) · Annals of Neurology · doi:10.1002/ana.1052 · Cited by 677
“Recently, an inverse association between coffee consumption and risk of Parkinson’s disease in men, but not in women, was reported from a study in Rochester, Minnesota.(15) Finally, a strong and highly significant inverse association between coffee intake and risk of Parkinson’s disease has been reported in a longitud…”
Background
Metadata
- Authors
- Benedetti, M. D., Bower, J. H., Maraganore, D. M., McDonnell, S. K., Peterson, B. J., Ahlskog, J. E., Schaid, D. J., & Rocca, W. A.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 2000-11-14
- Volume
- 55
- Issue
- 9
- Pages
- 1350-1358
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2172189733
- Cited by
- 234
- References
- 34
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 10
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS033978, NS33978)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, coffee consumption, cigarette smoking, alcohol consumption, risk factors, age of onset, tobacco chewing, snuff use, alcoholism, Rochester Epidemiology Project, Rochester, Minnesota
- MeSH terms
- Adult, Aged, Alcohol Drinking, Coffee, Female, Humans, Male, Middle Aged, Minnesota, Parkinson Disease, Smoking, Case-Control Studies
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