The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Regional brain chemical alterations in young children with autism spectrum disorder
Abstract
OBJECTIVE: The authors evaluated regional brain chemistry for evidence of increased neuronal packing density in autism. METHODS: Forty-five 3- to 4-year-old children with autism spectrum disorder (ASD), 13 children with typical development (TD), and 15 children with delayed development (DD) were studied using dual-echo proton echoplanar spectroscopic imaging (32 x 32 matrix-1 cm(3) voxels) to measure brain chemical concentrations and relaxation times. Chemical quantification was corrected for tissue partial volume and relative measures of chemical relaxation (T(2r)) were calculated from the paired echoes. Measures from averaged and individual regions were compared using analysis of variance corrected for multiple comparisons. RESULTS: ASD subjects demonstrated reduced N-acetylaspartate (NAA) (-10%), creatine (Cre) (-8%), and myo-inositol (-13%) concentrations compared to TD controls and prolonged NAA T(2r) relative to TD (7%) and DD (9%) groups. Compared to DD subjects, children with ASD also demonstrated prolonged T(2r) for choline (10%) and Cre (9%). Regional analyses demonstrated subtle patterns of chemical alterations in ASD compared to the TD and DD groups. CONCLUSIONS: Brain chemical abnormalities are present in ASD at 3 to 4 years of age. However, the direction and widespread distribution of these abnormalities do not support hypothesis of diffuse increased neuronal packing density in ASD.
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Cites
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487
Histoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964
Brain structural abnormalities in young children with autism spectrum disorder
Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., et al. (2002) · Neurology · doi:10.1212/wnl.59.2.184 · Cited by 961
Self-citationMinicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846
Neuropsychological Correlates of Early Symptoms of Autism
Dawson, G., Meltzoff, A. N., Osterling, J., & Rinaldi, J. (1998) · Child Development · doi:10.2307/1132265 · Cited by 289
Self-citationDo active cerebral neurons really use lactate rather than glucose?
Chih, C.-P., Lipton, P., & Roberts, E. L. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01920-2 · Cited by 252
Zhu, X., & Chen, W. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1267 · Cited by 92
Cited by
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Dawson, G. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000370 · Cited by 1,138
Self-citationLocalization of white matter volume increase in autism and developmental language disorder
Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S. (2004) · Annals of Neurology · doi:10.1002/ana.20032 · Cited by 663
Autism as a neural systems disorder: A theory of frontal-posterior underconnectivity
Just, M. A., Keller, T. A., Malave, V. L., Kana, R. K., & Varma, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.007 · Cited by 578
The impact of atypical sensory processing on social impairments in autism spectrum disorder
Thye, M. D., Bednarz, H. M., Herringshaw, A. J., Sartin, E. B., & Kana, R. K. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.04.010 · Cited by 513
“…Nair et al., 2013), decreased thalamic volume (Tsatsanis et al., 2003; Tamura et al., 2010), lower levels of N-acetylasparate, phosphocreatine, creatin, and choline-containing metabolites (Hardan et al., 2008; Haznedar et al., 2006), and reduced neuronal integrity (Friedman et al., 2003) in ASD.”
Deoni, S. C. L., Peters, T. M., & Rutt, B. K. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20314 · Cited by 478
Metadata
- Authors
- Friedman, S. D., Shaw, D. W., Artru, A. A., Richards, T. L., Gardner, J., Dawson, G., Posse, S., & Dager, S. R.
- Venue
- Neurology
- Published
- 2003-01-14
- Volume
- 60
- Issue
- 1
- Pages
- 100-107
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2024579174
- Cited by
- 179
- References
- 8
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
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