Observed BOLD effects on cerebral metabolite resonances in human visual cortex during visual stimulation: A functional 1 H MRS study at 4 T

Zhu, Xiao‐Hong; Chen, Wei

doi:10.1002/mrm.1267

Cited by 92Advanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and ApplicationsNMR spectroscopy and applications

Observed BOLD effects on cerebral metabolite resonances in human visual cortex during visual stimulation: A functional 1 H MRS study at 4 T

Zhu, Xiao‐Hong, Chen, Wei·2001·Magnetic Resonance in Medicine

DOI 10.1002/mrm.1267

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Abstract

Using the localized spin‐echo 1 H MRS technique, the water resonance and methyl resonance peaks of the cerebral metabolites N‐acetylaspartate (NAA at 2.0 ppm) and phosphocreatine/creatine (Cr at 3.0 ppm) were studied in the human visual cortex to detect and quantify the blood oxygenation level dependent (BOLD) effect during visual stimulation at 4 T. Significant BOLD effects, which reflect the increases of spectral peak height (H) accompanied by the decreases of spectral linewidth (Δυ 1/2 ), were observed in NAA (H: 2.5%; Δυ 1/2 : −1.7%) and Cr (H: 3.1%; Δυ 1/2 : −1.8%) as well as in water (H: 3.1%; Δυ 1/2 : −2.3%). Because NAA and Cr mainly exist in the brain cells, the BOLD effects on these cerebral metabolite resonances only measure the susceptibility component spreading into the extravascular cellular compartment. In contrast, water is affected in the intra‐ and the extravascular compartments. Therefore, the water signal measures the BOLD effects in both compartments. BOLD responses in water were similar to those observed in metabolites. The similarity indicates that the susceptibility spreading into the extravascular parenchyma contributed significantly to the observed BOLD effects at 4 T. Finally, taking advantage of the higher NMR sensitivity at 4 T, the feasibility of measuring BOLD effects on cerebral metabolites by localized 1 H MRS is demonstrated. Magn Reson Med 46:841–847, 2001. © 2001 Wiley‐Liss, Inc.

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The difference spectra featured narrow peaks corresponding to the main singlets of the spectrum, particularly tCr and tNAA, as a result of BOLD-induced line narrowing.
“The difference spectra also featured some narrow peaks corresponding to the main singlets of the spectrum, particularly tCr and tNAA, as a result of BOLD-induced line narrowing (Zhu and Chen, 2001).”
From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as Zhu and Chen, 2001

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Authors: Zhu, X., & Chen, W.
Affiliations: University of Minnesota (US)
Corresponding author: Chen, Wei
Venue: Magnetic Resonance in Medicine
Publisher: Wiley
Published: 2001-10-18
Volume: 46
Issue: 5
Pages: 841-847
ISSN: 0740-3194 (ISSN-L)
1522-2594
DOI: 10.1002/mrm.1267
OpenAlex: W2008261754
Cited by: 92
References: 27
Citations by year: 2026: 4 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 3 · 2012: 2
FWCI: 2.96
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Magnetic Resonance in Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS39043, NS38070, R01NS039043, R01NS038070)
National Center for Research Resources (P41RR008079, P41RR08079)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords: BOLD effect, brain metabolites, N-acetylaspartate, visual cortex, visual stimulation, spectral linewidth
MeSH terms: Adult, Aspartic Acid, Creatine, Female, Humans, Magnetic Resonance Imaging, Male, Magnetic Resonance Spectroscopy, Phosphocreatine, Photic Stimulation, Visual Cortex

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Observed BOLD effects on cerebral metabolite resonances in human visual cortex during visual stimulation: A functional 1 H MRS study at 4 T

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