The staging and assessment of moderate to severe Alzheimer disease
Abstract
Alzheimer disease (AD) and its stages are clinically defined by the patterns of gradual and progressive decline in cognition and in functional ability with accompanying neuropsychiatric symptoms. The moderate to severe AD (MSAD) stages are particularly important both for their prevalence and for the transitions that occur at these stages. In MSAD, cognitive losses accelerate, neuropsychiatric symptoms increase, and functional autonomy is lost. There is increasing burden on caregivers, who report poorer self-rated health, increased depressive symptoms, and more use of psychoactive medications. The neurologic care of MSAD demands both skilled assessment and management. Beyond the cognitive and neurobehavioral symptom complex in MSAD, a range of other issues also emerge, including gait and movement disorders, nutritional problems, and incontinence. This review addresses the symptoms and staging of AD and emphasizes the key management issues.
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Distinct linguistic deficits have been observed in Alzheimer's disease, including lexico-semantic impairment, simplified syntax and altered figurative language processing.
“Distinct deficits have been observed in Alzheimer's disease (lexico-semantic impairment, 2,29 simplified syntax, 13 altered figurative language processing 16 )”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [29]
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- Authors
- Feldman, H. H., & Woodward, M.
- Affiliations
- University of British Columbia (CA)
- Venue
- Neurology
- Published
- 2005-09-27
- Volume
- 65
- Issue
- 6_suppl_3
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1994198632
- Cited by
- 105
- References
- 95
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 2 · 2013: 8 · 2012: 4
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- Alzheimer's disease, disease staging, cognitive decline, functional decline, neuropsychiatric symptoms, caregiver burden, functional autonomy, nutritional disorders, incontinence, psychotropic drugs, depressive symptoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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