Cited by 105Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPalliative Care and End-of-Life Issues

The staging and assessment of moderate to severe Alzheimer disease

Feldman, H. H., Woodward, M.·2005·Neurology

Abstract

Alzheimer disease (AD) and its stages are clinically defined by the patterns of gradual and progressive decline in cognition and in functional ability with accompanying neuropsychiatric symptoms. The moderate to severe AD (MSAD) stages are particularly important both for their prevalence and for the transitions that occur at these stages. In MSAD, cognitive losses accelerate, neuropsychiatric symptoms increase, and functional autonomy is lost. There is increasing burden on caregivers, who report poorer self-rated health, increased depressive symptoms, and more use of psychoactive medications. The neurologic care of MSAD demands both skilled assessment and management. Beyond the cognitive and neurobehavioral symptom complex in MSAD, a range of other issues also emerge, including gait and movement disorders, nutritional problems, and incontinence. This review addresses the symptoms and staging of AD and emphasizes the key management issues.

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Crossref · 10.1212/wnl.65.6_suppl_3.s10

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95 of 95 references verified0 citation errors · 0 not checkable

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  • Distinct linguistic deficits have been observed in Alzheimer's disease, including lexico-semantic impairment, simplified syntax and altered figurative language processing.

    “Distinct deficits have been observed in Alzheimer's disease (lexico-semantic impairment, 2,29 simplified syntax, 13 altered figurative language processing 16 )”

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Authors
Feldman, H. H., & Woodward, M.
Affiliations
University of British Columbia (CA)
Venue
Neurology
Published
2005-09-27
Volume
65
Issue
6_suppl_3
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W1994198632
Cited by
105
References
95
Citations by year
2026: 4 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 2 · 2013: 8 · 2012: 4
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Locations
Neurology (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Keywords
Alzheimer's disease, disease staging, cognitive decline, functional decline, neuropsychiatric symptoms, caregiver burden, functional autonomy, nutritional disorders, incontinence, psychotropic drugs, depressive symptoms

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