The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Subanesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain
Abstract
In Brief Drugs that block N-methyl-d-aspartate glutamate receptors or that promote γ-aminobutyric acid type A inhibition trigger neuroapoptosis in the developing rodent brain. Propofol reportedly interacts with both γ-aminobutyric acid type A and N-methyl-d-aspartate glutamate receptors, but has not been adequately evaluated for its ability to induce developmental neuroapoptosis. Here we determined that the intraperitoneal (i.p.) dose of propofol required to induce a surgical plane of anesthesia in the infant mouse is 200 mg/kg. We then administered graduated doses of propofol (25–300 mg/kg i.p.) and found that doses ≥50 mg/kg induce a significant neuroapoptosis response. We conclude that propofol induces neuroapoptosis at 1/4 the dose required for surgical anesthesia. IMPLICATIONS: Propofol is used for sedation and anesthesia in pediatric and obstetric medicine. Subanesthetic exposure of infant mice to other anesthetics (ketamine, midazolam, and isoflurane) triggers neuroapoptosis in the developing brain. We now report that propofol, in subanesthetic doses, triggers neuroapoptosis in the infant mouse brain.
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Cites
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055
Self-citationEthanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
Ikonomidou, C., Bittigau, P., Ishimaru, M. J., Wozniak, D. F., Koch, C., Genz, K., Price, M. T., Stefovska, V., Hörster, F., Tenkova, T., et al. (2000) · Science · doi:10.1126/science.287.5455.1056 · Cited by 1,371
Self-citationAntiepileptic drugs and apoptotic neurodegeneration in the developing brain
Bittigau, P., Sifringer, M., Genz, K., Reith, E., Pospischil, D., Govindarajalu, S., Dzietko, M., Pesditschek, S., Mai, I., Dikranian, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222550499 · Cited by 779
Self-citationYoung, C., Jevtovic‐Todorovic, V., Qin, Y., Tenkova, T., Wang, H., Labruyere, J., & Olney, J. W. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706301 · Cited by 476
Self-citationYon, J.-H., Daniel-Johnson, J., Carter, L. B., & Jevtovic-Todorovic, V. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.064 · Cited by 467
Fredriksson, A., Pontén, E., Gordh, T., & Eriksson, P. (2007) · Anesthesiology · doi:10.1097/01.anes.0000278892.62305.9c · Cited by 420
Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience
Green, C. J., Knight, J., Precious, S., & Simpkin, S. (1981) · Laboratory Animals · doi:10.1258/002367781780959107 · Cited by 335
Ethanol-Induced Caspase-3 Activation in the in Vivo Developing Mouse Brain
Olney, J. W., Tenkova, T., Dikranian, K., Muglia, L. J., Jermakowicz, W. J., D'Sa, C., & Roth, K. A. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0475 · Cited by 241
Self-citationGeneral anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
Lu, L. X., Yon, J.-H., Carter, L. B., & Jevtovic-Todorovic, V. (2006) · Apoptosis · doi:10.1007/s10495-006-8762-3 · Cited by 237
Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain
Ishimaru, M. J., Ikonomidou, C., Tenkova, T. I., Der, T. C., Dikranian, K. T., Sesma, M. A., & Olney, J. W. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990614)408:4<461::aid-cne2>3.0.co;2-9 · Cited by 205
Self-citation
Cited by
Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort
Wilder, R. T., Flick, R. P., Sprung, J., Katusic, S. K., Barbaresi, W. J., Mickelson, C., Gleich, S. J., Schroeder, D. R., Weaver, A. L., & Warner, D. O. (2009) · Anesthesiology · doi:10.1097/01.anes.0000344728.34332.5d · Cited by 1,364
Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia
Ing, C., DiMaggio, C., Whitehouse, A., Hegarty, M. K., Brady, J., von Ungern-Sternberg, B. S., Davidson, A., Wood, A. J. J., Li, G., & Sun, L. S. (2012) · Pediatrics · doi:10.1542/peds.2011-3822 · Cited by 607
Creeley, C., Dikranian, K., Dissen, G., Martin, L., Olney, J., & Brambrink, A. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet173 · Cited by 468
Self-citationKetamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain
Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Martin, L. D., Dissen, G. A., Creeley, C. E., & Olney, J. W. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318242b2cd · Cited by 425
Self-citationPropofol: A Review of its Role in Pediatric Anesthesia and Sedation
Chidambaran, V., Costandi, A., & D’Mello, A. (2015) · CNS Drugs · doi:10.1007/s40263-015-0259-6 · Cited by 356
Metadata
- Authors
- Cattano, D., Young, C., Straiko, M. M. W., & Olney, J. W.
- Venue
- Anesthesia & Analgesia
- Published
- 2008-06
- Volume
- 106
- Issue
- 6
- Pages
- 1712-1714
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W2021796111
- Cited by
- 272
- References
- 16
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cattano, D., Young, C., Straiko, M. M. W., & Olney, J. W. (2008). Subanesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain. Anesthesia & Analgesia. https://doi.org/10.1213/ane.0b013e318172ba0a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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