The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players
Abstract
OBJECTIVE: Cerebral concussion is common in collision sports such as football, yet the chronic neurological effects of recurrent concussion are not well understood. The purpose of our study was to investigate the association between previous head injury and the likelihood of developing mild cognitive impairment (MCI) and Alzheimer's disease in a unique group of retired professional football players with previous head injury exposure. METHODS: A general health questionnaire was completed by 2552 retired professional football players with an average age of 53.8 (±13.4) years and an average professional football playing career of 6.6 (± 3.6) years. A second questionnaire focusing on memory and issues related to MCI was then completed by a subset of 758 retired professional football players (≥50 yr of age). Results on MCI were then cross-tabulated with results from the original health questionnaire for this subset of older retirees. RESULTS: Of the former players, 61% sustained at least one concussion during their professional football career, and 24% sustained three or more concussions. Statistical analysis of the data identified an association between recurrent concussion and clinically diagnosed MCI (χ2 = 7.82, df = 2, P = 0.02) and self-reported significant memory impairments (χ2 = 19.75, df = 2, P = 0.001). Retired players with three or more reported concussions had a fivefold prevalence of MCI diagnosis and a threefold prevalence of reported significant memory problems compared with retirees without a history of concussion. Although there was not an association between recurrent concussion and Alzheimer's disease, we observed an earlier onset of Alzheimer's disease in the retirees than in the general American male population CONCLUSION: Our findings suggest that the onset of dementia-related syndromes may be initiated by repetitive cerebral concussions in professional football players.
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“Our third finding, on the effects of recurrent injuries, is broadly consistent with the emerging literature on the adverse consequences of sports and combat-related neurotrauma [7,9,11–14,46–49].”
In the citing paper
“Epidemiological studies have consistently found higher rates of adverse outcomes in adults who have sustained a TBI when compared to the general population [7–16].”
In the citing paper
“surveys of retired professional football players found that players who reported sustaining three or more concussions were significantly more likely to report cognitive symptoms, including a threefold increase in self-reported significant memory impairment and a fivefold increase in diagnosed mild cognitive impairment [77].”
From The neuropathology of sport (2014) · cites this paper as [77]
Citations
Cites
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,871
Brookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,802
Guskiewicz, K. M., McCrea, M., Marshall, S. W., Cantu, R. C., Randolph, C., Barr, W., Onate, J. A., & Kelly, J. P. (2003) · JAMA · doi:10.1001/jama.290.19.2549 · Cited by 1,712
Self-citationPrediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404
Epidemiology of Concussion in Collegiate and High School Football Players
Guskiewicz, K. M., Weaver, N. L., Padua, D. A., & Garrett, W. E. J. (2000) · The American Journal of Sports Medicine · doi:10.1177/03635465000280050401 · Cited by 851
Self-citationRates and risk factors for dementia and Alzheimer’s disease: Results from EURODEM pooled analyses
Launer, L. J., Andersen, K., Dewey, M. E., Letenneur, L., Ott, A., Amaducci, L. A., Brayne, C., Copeland, J. R. M., Dartigues, J.-F., Kragh-Sorensen, P., et al. (1999) · Neurology · doi:10.1212/wnl.52.1.78 · Cited by 758
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing
Jordan, B. D. (1997) · JAMA · doi:10.1001/jama.278.2.136 · Cited by 665
Self-citationMayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M. (1995) · Neurology · doi:10.1212/wnl.45.3.555 · Cited by 590
Research works printed but not linked: 4
- Mortimer, 1985, Head injury as risk factor for Alzheimer's disease., Neurology, 35, 264, 10.1212/WNL.35.2.264 · DOI · Paper page
- Roberts, 1990, The occult aftermath of boxing., J Neurol Neurosurg Psychiatry, 53, 373, 10.1136/jnnp.53.5.373 · DOI · Paper page
- Guskiewicz, 2003, Cumulative effects associated with recurrent concussion in collegiate football players. The NCAA Concussion Study., JAMA, 290, 2549, 10.1001/jama.290.19.2549 · DOI · Paper page
- Jordan, 1997, Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing., J Am Med Soc, 278, 136
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2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,372
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609
McCrory, P. R., Meeuwisse, W. H., Aubry, M., Cantu, B., Dvořák, J., Echemendía, R. J., Engebretsen, L., Johnston, K., Kutcher, J. S., Raftery, M., et al. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092313 · Cited by 2,669
Self-citationMcCrory, P. R., Meeuwisse, W. H., Aubry, M., Cantu, B., Dvořák, J., Echemendía, R. J., Engebretsen, L., Johnston, K., Kutcher, J., Raftery, M., et al. (2013) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2013.03.002 · Cited by 2,141
Self-citation
Metadata
- Authors
- Guskiewicz, K. M., Marshall, S. W., Bailes, J., McCrea, M., Cantu, R. C., Randolph, C., & Jordan, B. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- Neurosurgery
- Published
- 2005-10
- Volume
- 57
- Issue
- 4
- Pages
- 719-726
- ISSN
- 0148-396X (ISSN-L)
- OpenAlex
- W2105910930
- Cited by
- 1,197
- References
- 43
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 29 · 2023: 38 · 2022: 48 · 2021: 71 · 2020: 66 · 2019: 84 · 2018: 75 · 2017: 95 · 2016: 88 · 2015: 100 · 2014: 92 · 2013: 93 · 2012: 70
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- recurrent concussion, mild cognitive impairment, Alzheimer's disease, traumatic brain injury, memory impairment, dementia onset, chronic traumatic encephalopathy, sports-related brain injury
- MeSH terms
- Adult, Age Factors, Aged, Alzheimer Disease, Brain Concussion, Cognition Disorders, Football, Health Surveys, Humans, Male, Middle Aged, Recurrence, Retirement
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