Cited by 1,197Traumatic Brain Injury ResearchDementia and Cognitive Impairment ResearchCognitive Functions and Memory

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players

Guskiewicz, Kevin M., Marshall, Stephen W., Bailes, Julian, McCrea, Michael, Cantu, Robert C., Randolph, Christopher, Jordan, Barry D.·2005·Neurosurgery

DOI 10.1227/01.neu.0000175725.75780.dd

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Cerebral concussion is common in collision sports such as football, yet the chronic neurological effects of recurrent concussion are not well understood. The purpose of our study was to investigate the association between previous head injury and the likelihood of developing mild cognitive impairment (MCI) and Alzheimer's disease in a unique group of retired professional football players with previous head injury exposure. METHODS: A general health questionnaire was completed by 2552 retired professional football players with an average age of 53.8 (±13.4) years and an average professional football playing career of 6.6 (± 3.6) years. A second questionnaire focusing on memory and issues related to MCI was then completed by a subset of 758 retired professional football players (≥50 yr of age). Results on MCI were then cross-tabulated with results from the original health questionnaire for this subset of older retirees. RESULTS: Of the former players, 61% sustained at least one concussion during their professional football career, and 24% sustained three or more concussions. Statistical analysis of the data identified an association between recurrent concussion and clinically diagnosed MCI (χ2 = 7.82, df = 2, P = 0.02) and self-reported significant memory impairments (χ2 = 19.75, df = 2, P = 0.001). Retired players with three or more reported concussions had a fivefold prevalence of MCI diagnosis and a threefold prevalence of reported significant memory problems compared with retirees without a history of concussion. Although there was not an association between recurrent concussion and Alzheimer's disease, we observed an earlier onset of Alzheimer's disease in the retirees than in the general American male population CONCLUSION: Our findings suggest that the onset of dementia-related syndromes may be initiated by repetitive cerebral concussions in professional football players.

Integrity signals

Registry

Crossref · 10.1227/01.neu.0000175725.75780.dd

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review) [RETIRED]: Report of the Quality Standards Subcommittee of the American Academy of Neurology
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,871
Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.
Brookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,802
Cumulative Effects Associated With Recurrent Concussion in Collegiate Football Players: The NCAA Concussion Study
Guskiewicz, K. M., McCrea, M., Marshall, S. W., Cantu, R. C., Randolph, C., Barr, W., Onate, J. A., & Kelly, J. P. (2003) · JAMA · doi:10.1001/jama.290.19.2549 · Cited by 1,712
Self-citation
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404
Epidemiology of Concussion in Collegiate and High School Football Players
Guskiewicz, K. M., Weaver, N. L., Padua, D. A., & Garrett, W. E. J. (2000) · The American Journal of Sports Medicine · doi:10.1177/03635465000280050401 · Cited by 851
Self-citation
Rates and risk factors for dementia and Alzheimer’s disease: Results from EURODEM pooled analyses
Launer, L. J., Andersen, K., Dewey, M. E., Letenneur, L., Ott, A., Amaducci, L. A., Brayne, C., Copeland, J. R. M., Dartigues, J.-F., Kragh-Sorensen, P., et al. (1999) · Neurology · doi:10.1212/wnl.52.1.78 · Cited by 758
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing
Jordan, B. D. (1997) · JAMA · doi:10.1001/jama.278.2.136 · Cited by 665
Self-citation
Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease
Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M. (1995) · Neurology · doi:10.1212/wnl.45.3.555 · Cited by 590

Show all 43 references

Research works printed but not linked: 4

Mortimer, 1985, Head injury as risk factor for Alzheimer's disease., Neurology, 35, 264, 10.1212/WNL.35.2.264 · DOI · Paper page
Roberts, 1990, The occult aftermath of boxing., J Neurol Neurosurg Psychiatry, 53, 373, 10.1136/jnnp.53.5.373 · DOI · Paper page
Guskiewicz, 2003, Cumulative effects associated with recurrent concussion in collegiate football players. The NCAA Concussion Study., JAMA, 290, 2549, 10.1001/jama.290.19.2549 · DOI · Paper page
Jordan, 1997, Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing., J Am Med Soc, 278, 136

Sorted by citations

2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,372
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609
Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012
McCrory, P. R., Meeuwisse, W. H., Aubry, M., Cantu, B., Dvořák, J., Echemendía, R. J., Engebretsen, L., Johnston, K., Kutcher, J. S., Raftery, M., et al. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092313 · Cited by 2,669
Self-citation
Consensus statement on Concussion in Sport – The 4th International Conference on Concussion in Sport held in Zurich, November 2012
McCrory, P. R., Meeuwisse, W. H., Aubry, M., Cantu, B., Dvořák, J., Echemendía, R. J., Engebretsen, L., Johnston, K., Kutcher, J., Raftery, M., et al. (2013) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2013.03.002 · Cited by 2,141
Self-citation
2018 Alzheimer's disease facts and figures
Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective
Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.016 · Cited by 1,660
2015 Alzheimer's disease facts and figures
Alzheimer's Association (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.02.003 · Cited by 1,684
American Medical Society for Sports Medicine position statement: concussion in sport
Harmon, K. G., Drezner, J. A., Gammons, M. R., Guskiewicz, K. M., Halstead, M., Herring, S. A., Kutcher, J. S., Pana, A., Putukian, M., & Roberts, W. O. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091941 · Cited by 1,433
Self-citation
2017 Alzheimer's disease facts and figures
(, T. D. B. T. A.-R. C. C. A. S. O. A. C. B. S., different, ). J. A. I. A., destroyed, S. A. T. A. S. T. M. E. T. M. C. I. S. I. A. G. W. A. T. R. N. I. T. O. B. T. F. N. T. B. D. A. D. A. U. I. B. R. I. I. F. N. M. A. N. I. O. P. O. T. B. A. D. A., difficulties, I. E. O., agitation, I. N. S. S. A., & delusions., S. A. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.02.001 · Cited by 1,366
Mental health in elite athletes: International Olympic Committee consensus statement (2019)
Reardon, C. L., Hainline, B., Aron, C. M., Baron, D., Baum, A. L., Bindra, A., Budgett, R., Campriani, N., Castaldelli-Maia, J. M., Currie, A., et al. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-100715 · Cited by 1,277
Axonal pathology in traumatic brain injury
Johnson, V. E., Stewart, W., & Smith, D. H. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.013 · Cited by 1,273
National Athletic Trainers' Association Position Statement: Management of Sport Concussion
Broglio, S. P., Cantu, R. C., Gioia, G. A., Guskiewicz, K. M., Kutcher, J. S., Palm, M., & McLeod, T. C. V. (2014) · Journal of Athletic Training · doi:10.4085/1062-6050-49.1.07 · Cited by 1,112
Self-citation
2014 Alzheimer's disease facts and figures
Alzheimer's Association (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.02.001 · Cited by 1,064
2012 Alzheimer's disease facts and figures Alzheimer's Association ∗
Thies, W. H., & Bleiler, L. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.001 · Cited by 1,014
Recurrent Concussion and Risk of Depression in Retired Professional Football Players
GUSKIEWICZ, K. M., MARSHALL, S. W., BAILES, J., MCCREA, M., HARDING, H. P., MATTHEWS, A., MIHALIK, J. R., & CANTU, R. C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180383da5 · Cited by 928
Self-citation
2011 Alzheimer's disease facts and figures
Alzheimer's Association (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.02.004 · Cited by 930
Consensus Statement on Concussion in Sport—The 4th International Conference on Concussion in Sport Held in Zurich, November 2012
McCrory, P. R., Meeuwisse, W. H., Aubry, M., Cantu, R. C., Dvořák, J., Echemendía, R. J., Engebretsen, L., Johnston, K. M., Kutcher, J. S., Raftery, M., et al. (2013) · PM&R · doi:10.1016/j.pmrj.2013.02.012 · Cited by 922
Self-citation
The neuropathology of traumatic brain injury
McKee, A. C., & Daneshvar, D. H. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52892-6.00004-0 · Cited by 899
Chronic neuropathologies of single and repetitive TBI: substrates of dementia?
Smith, D. H., Johnson, V. E., & Stewart, W. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.29 · Cited by 699
Consensus Statement on Concussion in Sport: The 3rd International Conference on Concussion in Sport Held in Zurich, November 2008
McCrory, P. R., Meeuwisse, W. H., Johnston, K., Dvořák, J., Aubry, M., Molloy, M., & Cantu, R. C. (2009) · Journal of Athletic Training · doi:10.4085/1062-6050-44.4.434 · Cited by 696
Self-citation
CHRONIC TRAUMATIC ENCEPHALOPATHY IN A NATIONAL FOOTBALL LEAGUE PLAYER: PART II
Omalu, B. I., DeKosky, S. T., Hamilton, R. L., Minster, R. L., Kamboh, M. I., Shakir, A. M., & Wecht, C. H. (2006) · Neurosurgery · doi:10.1227/01.neu.0000245601.69451.27 · Cited by 694
The Neuropathology and Neurobiology of Traumatic Brain Injury
Blennow, K., Hardy, J., & Zetterberg, H. (2012) · Neuron · doi:10.1016/j.neuron.2012.11.021 · Cited by 669
A systematic review of potential long-term effects of sport-related concussion.
Manley, G., Gardner, A. J., Schneider, K. J., Guskiewicz, K. M., Bailes, J., Cantu, R. C., Castellani, R. J., Turner, M., Jordan, B. D., Randolph, C., et al. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097791 · Cited by 663
Self-citation
Neurodegenerative causes of death among retired National Football League players
Lehman, E. J., Hein, M. J., Baron, S. L., & Gersic, C. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826daf50 · Cited by 638
The chronic and evolving neurological consequences of traumatic brain injury
Wilson, L., Stewart, W., Dams-O'Connor, K., Diaz-Arrastia, R., Horton, L., Menon, D. K., & Polinder, S. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30279-x · Cited by 607
Occurrence of mental health symptoms and disorders in current and former elite athletes: a systematic review and meta-analysis
Gouttebarge, V., Castaldelli-Maia, J. M., Gorczynski, P., Hainline, B., Hitchcock, M. E., Kerkhoffs, G. M., Rice, S. M., & Reardon, C. L. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-100671 · Cited by 604
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587
Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players
Montenigro, P. H., Alosco, M. L., Martin, B. M., Daneshvar, D. H., Mez, J., Chaisson, C. E., Nowinski, C. J., Au, R., McKee, A. C., Cantu, R. C., et al. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4413 · Cited by 605
Self-citation
Cognitive Reserve in Aging
M. Tucker, A., & Stern, Y. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745320 · Cited by 561
Role of subconcussion in repetitive mild traumatic brain injury
Bailes, J. E., Petraglia, A. L., Omalu, B. I., Nauman, E. A., & Talavage, T. M. (2013) · Journal of neurosurgery · doi:10.3171/2013.7.jns121822 · Cited by 549
Self-citation
The molecular pathophysiology of concussive brain injury
Barkhoudarian, G., Hovda, D. A., & Giza, C. C. (2011) · Clinics in Sports Medicine · doi:10.1016/j.csm.2010.09.001 · Cited by 492
Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008
McCrory, P. R., Meeuwisse, W. H., Johnston, K., Dvorak, J., Aubry, M., Molloy, M. J., & Cantu, R. C. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.058248 · Cited by 473
Self-citation
Cognitive Outcome Following Traumatic Brain Injury
DIKMEN, S. S., Corrigan, J. D., Levin, H. S., Machamer, J., Stiers, W. M., & Weisskopf, M. G. (2009) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181c133e9 · Cited by 495
Association of traumatic brain injury with subsequent neurological and psychiatric disease: A meta-analysis
Perry, D. C., Sturm, V. E., Peterson, M. J., Pieper, C. F., Bullock, T., Boeve, B. F., Miller, B. L., Guskiewicz, K. M., Berger, M. S., Kramer, J. H., et al. (2016) · Journal of Neurosurgery · doi:10.3171/2015.2.jns14503 · Cited by 440
Self-citation
Consensus Statement on Concussion in Sport: The 4th International Conference on Concussion in Sport, Zurich, November 2012
McCrory, P. R., Meeuwisse, W. H., Aubry, M., Cantu, R. C., Dvořák, J., Echemendía, R. J., Engebretsen, L., Johnston, K., Kutcher, J. S., Raftery, M., et al. (2013) · Journal of Athletic Training · doi:10.4085/1062-6050-48.4.05 · Cited by 469
Self-citation
Traumatic Brain Injury and Risk of Neurodegenerative Disorder
Brett, B. L., Gardner, R. C., Godbout, J. P., Dams-O’Connor, K., & Keene, C. D. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.025 · Cited by 453
Biomechanics of Concussion
Meaney, D. F., & Smith, D. H. (2010) · Clinics in Sports Medicine · doi:10.1016/j.csm.2010.08.009 · Cited by 428
The neuropathology of sport
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422
Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood
De Beaumont, L., Theoret, H., Mongeon, D., Messier, J., Leclerc, S., Tremblay, S., Ellemberg, D., & Lassonde, M. (2009) · Brain · doi:10.1093/brain/awn347 · Cited by 416
Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans
Barnes, D. E., Byers, A. L., Gardner, R. C., Seal, K. H., Boscardin, W. J., & Yaffe, K. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0815 · Cited by 398
The neuropsychological outcomes of concussion: A systematic review of meta-analyses on the cognitive sequelae of mild traumatic brain injury.
Karr, J. E., Areshenkoff, C. N., & García-Barrera, M. A. (2013) · Neuropsychology · doi:10.1037/neu0000037 · Cited by 428
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
Tagge, C. A., Fisher, A. M., Minaeva, O. V., Gaudreau, A., Moncaster, J. A., Zhang, X.-L., Wojnarowicz, M. W., Casey, N. F., Lu, H., Kokiko‐Cochran, O. N., et al. (2017) · Brain · doi:10.1093/brain/awx350 · Cited by 402
Self-citation
The clinical spectrum of sport-related traumatic brain injury
Jordan, B. D. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.33 · Cited by 347
Self-citation
A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members: The NCAA–DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods
Broglio, S. P., McCrea, M., McAllister, T. W., Harezlak, J., Katz, B. P., Hack, D. C., & Hainline, B. W. (2017) · Sports Medicine · doi:10.1007/s40279-017-0707-1 · Cited by 340
Self-citation
Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model
Mouzon, B., Bachmeier, C. J., Ferro, A., Ojo, J., Crynen, G. C., Acker, C. M., Davies, P., MULLAN, M. J., Stewart, W. B., Jr., & Crawford, F. (2013) · Annals of Neurology · doi:10.1002/ana.24064 · Cited by 341
Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study
Fann, J. R., Ribe, A. R., Pedersen, H. S., Fenger-Grøn, M., Christensen, J., Benros, M. E., & Vestergaard, M. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30065-8 · Cited by 322
A mouse model of human repetitive mild traumatic brain injury
Kane, M. J., Angoa‐Pérez, M., Briggs, D. I., Viano, D. C., Kreipke, C. W., & Kuhn, D. M. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.09.003 · Cited by 334
Traumatic brain injury and risk of dementia in older veterans
Barnes, D. E., Kaup, A. R., Kirby, K. A., Byers, A. L., Diaz-Arrastia, R. R., & Yaffe, K. S. (2014) · Neurology · doi:10.1212/wnl.0000000000000616 · Cited by 326
American Medical Society for Sports Medicine Position Statement
Harmon, K. G., Drezner, J. A., Gammons, M. R., Guskiewicz, K. M., Halstead, M., Herring, S., Kutcher, J., Pana, A., Putukian, M., & Roberts, W. O. (2012) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e31827f5f93 · Cited by 318
Self-citation
Neuroimaging of Cognitive Dysfunction and Depression in Aging Retired National Football League Players: A Cross-sectional Study
Hart, J., Kraut, M. A., Womack, K. B., Strain, J., Didehbani, N., Bartz, E., Conover, H., Mansinghani, S., Lu, H., & Cullum, C. M. (2013) · JAMA Neurology · doi:10.1001/2013.jamaneurol.340 · Cited by 315
The King–Devick test and sports-related concussion: Study of a rapid visual screening tool in a collegiate cohort
Galetta, K. M., Brandes, L. E., Maki, K., Dziemianowicz, M. S., Laudano, E., Allen, M. S., Lawler, K. A., Sennett, B. J., Wiebe, D. J., Devick, S., et al. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.07.039 · Cited by 303
The King-Devick test as a determinant of head trauma and concussion in boxers and MMA fighters
Galetta, K. M., Barrett, J., Allen, M., Madda, F., Delicata, D., Tennant, A. T., Branas, C. C., Maguire, M. G., Messner, L. V., Devick, S., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821184c9 · Cited by 302
Response of the cerebral vasculature following traumatic brain injury
Salehi, A., Zhang, J. H., & Obenaus, A. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17701460 · Cited by 306
A Diffusion Tensor Imaging Study on the White Matter Skeleton in Individuals with Sports-Related Concussion
Cubon, V. A., Putukian, M., Boyer, C., & Dettwiler, A. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1430 · Cited by 297
TEMPORAL WINDOW OF METABOLIC BRAIN VULNERABILITY TO CONCUSSIONS
Tavazzi, B., Vagnozzi, R., Signoretti, S., Amorini, A. M., Finocchiaro, A., Cimatti, M., Delfini, R., Pietro, V. D., Belli, A., & Lazzarino, G. (2007) · Neurosurgery · doi:10.1227/01.neu.0000255525.34956.3f · Cited by 297
Repetitive Mild Traumatic Brain Injury in a Mouse Model Produces Learning and Memory Deficits Accompanied by Histological Changes
Mouzon, B., Chaytow, H., Crynen, G. C., Bachmeier, C. J., Stewart, J., MULLAN, M. J., Stewart, W. B., Jr., & Crawford, F. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2498 · Cited by 298
Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology
Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 308
Biomechanical correlates of symptomatic and asymptomatic neurophysiological impairment in high school football
Breedlove, E. L., Robinson, M., Talavage, T. M., Morigaki, K. E., Yoruk, U., O'Keefe, K., King, J., Leverenz, L. J., Gilger, J. W., & Nauman, E. A. (2012) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2012.01.034 · Cited by 293
Development of the STAR Evaluation System for Football Helmets: Integrating Player Head Impact Exposure and Risk of Concussion
Rowson, S., & Duma, S. M. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0322-5 · Cited by 293
Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury
Faden, A. I., Wu, J., Stoica, B. A., & Loane, D. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13179 · Cited by 299
Age of first exposure to football and later-life cognitive impairment in former NFL players
Stamm, J. M., Bourlas, A. P., Baugh, C. M., Fritts, N. G., Daneshvar, D. H., Martin, B. M., McClean, M. D., Tripodis, Y., & Stern, R. A. (2015) · Neurology · doi:10.1212/wnl.0000000000001358 · Cited by 278
The Prevalence of Undiagnosed Concussions in Athletes
Meehan, W. P., III, Mannix, R., O’Brien, M. J., & Collins, M. W. (2013) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e318291d3b3 · Cited by 270
Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers
DeKosky, S. T., Blennow, K., Ikonomović, M. D., & Gandy, S. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.36 · Cited by 273
Mild traumatic brain injury and posttraumatic stress disorder in returning veterans: Perspectives from cognitive neuroscience
Vasterling, J. J., Verfaellie, M. H., & Sullivan, K. D. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.08.004 · Cited by 279
Molecular mechanisms of cognitive dysfunction following traumatic brain injury
Walker, K. R., & Tesco, G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00029 · Cited by 265
Risk factors for sports concussion: an evidence-based systematic review
Abrahams, S., Fie, S. M., Patricios, J., Posthumus, M., & September, A. V. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092734 · Cited by 264
Long-Term Outcomes Associated with Traumatic Brain Injury in Childhood and Adolescence: A Nationwide Swedish Cohort Study of a Wide Range of Medical and Social Outcomes
Sariaslan, A., Sharp, D. J., D’Onofrio, B. M., Larsson, H., & Fazel, S. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002103 · Cited by 262
Motivations associated with non-disclosure of self-reported concussions in former collegiate athletes
Kerr, Z., Register-Mihalik, J., Kroshus, E., Baugh, C. M., & Marshall, S. (2015) · American Journal of Sports Medicine · doi:10.1177/0363546515612082 · Cited by 239
Self-citation
Chronic traumatic encephalopathy (CTE) in a National Football League Player
Omalu, B. I., Hamilton, R. L., Kamboh, M. I., DeKosky, S. T., & Bailes, J. E. (2010) · Journal of Forensic Nursing · doi:10.1111/j.1939-3938.2009.01064.x · Cited by 260
Self-citation
Management of Pediatric Mild Traumatic Brain Injury: A Neuropsychological Review From Injury Through Recovery
Kirkwood, M. W., Yeates, K. O., Taylor, H. G., RANDOLPH, C. C., McCrea, M., & Anderson, V. A. (2008) · The Clinical Neuropsychologist · doi:10.1080/13854040701543700 · Cited by 265
Self-citation
Cumulative Head Impact Burden in High School Football
Broglio, S. P., Eckner, J. T., Martini, D. N., Sosnoff, J. J., Kutcher, J. S., & RANDOLPH, C. C. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1825 · Cited by 266
Self-citation
Disclosure and non-disclosure of concussion and concussion symptoms in athletes: Review and application of the socio-ecological framework
Kerr, Z. Y., Register‐Mihalik, J. K., Marshall, S. W., Evenson, K. R., Mihalik, J. P., & Guskiewicz, K. M. (2014) · Brain Injury · doi:10.3109/02699052.2014.904049 · Cited by 248
Self-citation
Cognitive decline in older adults with a history of traumatic brain injury
Moretti, L., Cristofori, I., Weaver, S. M., Chau, A., Tremont, J. N. P., & Grafman, J. H. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70226-0 · Cited by 252
Epidemiology of Sport-Related Concussions in High School Athletes: National Athletic Treatment, Injury and Outcomes Network (NATION), 2011-2012 Through 2013-2014.
O'Connor, K., Baker, M. M., Dalton, S. L., Dompier, T. P., Broglio, S., & Kerr, Z. (2017) · Journal of athletic training · doi:10.4085/1062-6050-52.1.15 · Cited by 219
Generalizability
Kukull, W. A., & Ganguli, M. (2012) · Neurology · doi:10.1212/wnl.0b013e318258f812 · Cited by 239
Repeat Traumatic Brain Injury in the Juvenile Rat Is Associated with Increased Axonal Injury and Cognitive Impairments
Prins, M. L., Hales, A., Reger, M. L., Giza, C. C., & Hovda, D. A. (2010) · Developmental Neuroscience · doi:10.1159/000316800 · Cited by 237
LONG-TERM AND CUMULATIVE EFFECTS OF SPORTS CONCUSSION ON MOTOR CORTEX INHIBITION
Beaumont, L. D., Lassonde, M. C., Leclerc, S., & Théoret, H. (2007) · Neurosurgery · doi:10.1227/01.neu.0000280000.03578.b6 · Cited by 242
Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study
Coughlin, J. M., Wang, Y., Munro, C. A., Ma, S., Chen, Y., Chen, S., Airan, R. D., Kim, P. K., Adams, A. V., Garcia, C., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.019 · Cited by 244
The epidemiology of new versus recurrent sports concussions among high school athletes, 2005–2010
Castile, L., Collins, C. L., McIlvain, N. M., & Comstock, R. D. (2011) · British Journal of Sports Medicine · doi:10.1136/bjsports-2011-090115 · Cited by 229
Rehabilitation of Concussion and Post-concussion Syndrome
Leddy, J. J., Sandhu, H., Sodhi, V., Baker, J. G., & Willer, B. S. (2012) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738111433673 · Cited by 229
Consensus Statement on Concussion in Sport – The 3rd International Conference on Concussion in Sport Held in Zurich, November 2008
McCrory, P. R., Meeuwisse, W. H., Johnston, K., Dvořák, J., Aubry, M., Molloy, M., & Cantu, R. C. (2009) · PM&R · doi:10.3810/psm.2009.06.1721 · Cited by 228
Self-citation
Concussion Increases Odds of Sustaining a Lower Extremity Musculoskeletal Injury After Return to Play Among Collegiate Athletes
Brooks, M. A., Peterson, K., Biese, K. M., Sanfilippo, J. L., Heiderscheit, B. C., & Bell, D. R. (2016) · The American Journal of Sports Medicine · doi:10.1177/0363546515622387 · Cited by 239
PET Scanning of Brain Tau in Retired National Football League Players: Preliminary Findings
Small, G. W., Kepe, V., Siddarth, P., Ercoli, L. M., Merrill, D. A., Donoghue, N., Bookheimer, S. Y., Martinez, J., Omalu, B. I., Bailes, J. E., et al. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.11.019 · Cited by 225
Self-citation
Repeated Mild Traumatic Brain Injury
Fehily, B., & Fitzgerald, M. (2017) · Cell Transplantation · doi:10.1177/0963689717714092 · Cited by 240
The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments
Morganti-Kossmann, M. C., Semple, B. D., Hellewell, S. C., Bye, N., & Ziebell, J. M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1944-6 · Cited by 227
The Spectrum of Neurobehavioral Sequelae after Repetitive Mild Traumatic Brain Injury: A Novel Mouse Model of Chronic Traumatic Encephalopathy
Petraglia, A. L., Plog, B. A., Dayawansa, S., Chen, M. J., Dashnaw, M. L., Czerniecka, K. H., Walker, C. T., Viterise, T., Hyrien, O., Iliff, J. J., et al. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3255 · Cited by 219
Long-Term Cognitive and Neuropsychiatric Consequences of Repetitive Concussion and Head-Impact Exposure
McAllister, T. W., & McCrea, M. (2017) · Journal of Athletic Training · doi:10.4085/1062-6050-52.1.14 · Cited by 219
Self-citation
Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease
Bondi, M. W., Jak, A. J., Delano-Wood, L., Jacobson, M. W., Delis, D. C., & Salmon, D. P. (2008) · Neuropsychology Review · doi:10.1007/s11065-008-9054-1 · Cited by 216
Sensitivity and Specificity of Subacute Computerized Neurocognitive Testing and Symptom Evaluation in Predicting Outcomes After Sports-Related Concussion
Lau, B. C., Collins, M. W., & Lovell, M. R. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546510392016 · Cited by 216
Epidemiology of Head Injuries Focusing on Concussions in Team Contact Sports: A Systematic Review
Prien, A., Grafe, A., Rößler, R., Junge, A., & Verhagen, E. A. L. M. (2018) · Sports Medicine · doi:10.1007/s40279-017-0854-4 · Cited by 231
Statements of Agreement From the Targeted Evaluation and Active Management (TEAM) Approaches to Treating Concussion Meeting Held in Pittsburgh, October 15-16, 2015
Collins, M. W., Kontos, A. P., Okonkwo, D. O., Almquist, J. L., Bailes, J. E., Barisa, M. T., Bazarian, J. J., Bloom, O. J., Brody, D. L., Cantu, R. C., et al. (2016) · Neurosurgery · doi:10.1227/neu.0000000000001447 · Cited by 208
Self-citation
Measuring Head Kinematics in Football: Correlation Between the Head Impact Telemetry System and Hybrid III Headform
Beckwith, J. G., Greenwald, R. M., & Chu, J. J. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0422-2 · Cited by 205
The Molecular Pathophysiology of Concussive Brain Injury – an Update
Barkhoudarian, G., Hovda, D. A., & Giza, C. C. (2016) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2016.01.003 · Cited by 203
Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes
Alosco, M. L., Kasimis, A. B., Stamm, J. M., Chua, A. S., Baugh, C. M., Daneshvar, D. H., Robbins, C. A., Mariani, M. L., Hayden, J., Conneely, S. E., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.197 · Cited by 214
Self-citation
Neurological consequences of traumatic brain injuries in sports
Ling, H., Hardy, J., & Zetterberg, H. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.03.012 · Cited by 197
Regulatory and autoregulatory physiological dysfunction as a primary characteristic of post concussion syndrome: Implications for treatment
Leddy, J. J., Kozlowski, K. F., Fung, M., Pendergast, D. R., & Willer, B. S. (2007) · Neurorehabilitation · doi:10.3233/nre-2007-22306 · Cited by 198
Concussion Incidence and Trends in 20 High School Sports
Kerr, Z. Y., Chandran, A. S., Nedimyer, A. K., Arakkal, A. T., Pierpoint, L. A., & Zuckerman, S. L. (2019) · PEDIATRICS · doi:10.1542/peds.2019-2180 · Cited by 194
Long-term Neurologic Outcomes After Traumatic Brain Injury
Bazarian, J. J., Černak, I., Noble‐Haeusslein, L. J., Potolicchio, S. J., & Temkin, N. R. (2009) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181c15600 · Cited by 203
The Relationship Between Subconcussive Impacts and Concussion History on Clinical Measures of Neurologic Function in Collegiate Football Players
Gysland, S. M., Mihalik, J. P., Register-Mihalik, J. K., Trulock, S. C., Shields, E. W., & Guskiewicz, K. M. (2012) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0421-3 · Cited by 189
Self-citation

Authors: Guskiewicz, K. M., Marshall, S. W., Bailes, J., McCrea, M., Cantu, R. C., Randolph, C., & Jordan, B. D.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Guskiewicz, Kevin M.
Marshall, Stephen W.
Bailes, Julian
McCrea, Michael
Cantu, Robert C.
Randolph, Christopher
Jordan, Barry D.
Venue: Neurosurgery
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-10
Volume: 57
Issue: 4
Pages: 719-726
ISSN: 0148-396X (ISSN-L)
DOI: 10.1227/01.neu.0000175725.75780.dd
OpenAlex: W2105910930
Cited by: 1,197
References: 43
Citations by year: 2026: 21 · 2025: 29 · 2024: 29 · 2023: 38 · 2022: 48 · 2021: 71 · 2020: 66 · 2019: 84 · 2018: 75 · 2017: 95 · 2016: 88 · 2015: 100 · 2014: 92 · 2013: 93 · 2012: 70
FWCI: 10.21
Type: journal article
Language: en
Open access: closed
Locations: Neurosurgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: recurrent concussion, mild cognitive impairment, Alzheimer's disease, traumatic brain injury, memory impairment, dementia onset, chronic traumatic encephalopathy, sports-related brain injury
MeSH terms: Adult, Age Factors, Aged, Alzheimer Disease, Brain Concussion, Cognition Disorders, Football, Health Surveys, Humans, Male, Middle Aged, Recurrence, Retirement

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks