Functional brain imaging of tobacco use and dependence

BRODY, A

doi:10.1016/j.jpsychires.2005.04.012

Cited by 207Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on Behavior

Functional brain imaging of tobacco use and dependence

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BRODY, A·2006·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2005.04.012PMC PMC2876087

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Abstract

While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will achieve abstinence after 6 months or more of treatment. A greater understanding of the effects of smoking on brain function may (in conjunction with other lines of research) result in improved pharmacological (and behavioral) interventions. Many research groups have examined the effects of acute and chronic nicotine/cigarette exposure on brain activity using functional imaging; the purpose of this paper is to synthesize findings from such studies and present a coherent model of brain function in smokers. Responses to acute administration of nicotine/smoking include: a reduction in global brain activity; activation of the prefrontal cortex, thalamus, and visual system; activation of the thalamus and visual cortex during visual cognitive tasks; and increased dopamine (DA) concentration in the ventral striatum/nucleus accumbens. Responses to chronic nicotine/cigarette exposure include decreased monoamine oxidase (MAO) A and B activity in the basal ganglia and a reduction in alpha4beta2 nicotinic acetylcholine receptor (nAChR) availability in the thalamus and putamen. Taken together, these findings indicate that smoking enhances neurotransmission through cortico-basal ganglia-thalamic circuits either by direct stimulation of nAChRs, indirect stimulation via DA release or MAO inhibition, or a combination of these factors. Activation of this circuitry may be responsible for the effects of smoking seen in tobacco dependent subjects, such as improvements in attentional performance, mood, anxiety, and irritability.

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Nicotine acutely increases activity in the visual system, PFC, and thalamus, consistent with activation of corticobasal ganglia-thalamic brain circuits.
“Brain imaging studies have demonstrated that nicotine acutely increases the activity in the visual system, PFC, and thalamus which are consistent with activation of the corticobasal ganglia-thalamic brain circuits”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [24]
Heavy nicotine use through smoking tobacco is linked to neuropathy, often appearing as prefrontal gray matter atrophy.
“Heavy nicotine use in the form of smoking tobacco has been linked to neuropathy (Brody, 2006), often manifesting as prefrontal gray matter atrophy (Gallinat et al., 2006; Zhang et al., 2011).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Brody, 2006

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Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults.
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“While the majority of reviews to date have investigated the impact of tobacco smoke and nicotine on cognition and the brain specifically during adulthood (Brody, 2006; Ceballos, 2006; England et al., 2015; Heishman et al., 2010; Swan and Lessov-Schlaggar, 2007; Valentine and Sofuoglu, 2018; Waisman Campos et al., 2016…”
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Neurobiological Impact of Nicotinic Acetylcholine Receptor Agonists: An Activation Likelihood Estimation Meta-Analysis of Pharmacologic Neuroimaging Studies
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An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation
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A case of musical preference for Johnny Cash following deep brain stimulation of the nucleus accumbens
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Influences of mood variability, negative moods, and depression on adolescent cigarette smoking.
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Therapy for Specific Problems: Youth Tobacco Cessation
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Co‐occurrence of obsessive‐compulsive disorder and substance use disorder in the general population
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Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits
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Chronic Smoking Is Associated With Differential Neurocognitive Recovery in Abstinent Alcoholic Patients: A Preliminary Investigation
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Effects of Chronic Alcohol Dependence and Chronic Cigarette Smoking on Cerebral Perfusion: A Preliminary Magnetic Resonance Study
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More than just statics: Temporal dynamic changes of intrinsic brain activity in cigarette smoking
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Smoking increases risk of pain chronification through shared corticostriatal circuitry
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Authors: BRODY, A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: BRODY, A
ORCID: BRODY, A
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2006-08
Volume: 40
Issue: 5
Pages: 404-418
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2005.04.012
PMC: PMC2876087
OpenAlex: W2047492603
Cited by: 207
References: 178
Citations by year: 2026: 5 · 2025: 4 · 2024: 9 · 2023: 9 · 2022: 2 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 12
FWCI: 7.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Institute on Drug Abuse (R01DA020872, R01 DA 15059, R01DA015059)
Topics: Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: tobacco dependence, smoking, nicotine, brain function, prefrontal cortex, thalamus, visual cortex, dopamine, nucleus accumbens, monoamine oxidase, nicotinic acetylcholine receptors, alpha4beta2 receptor, basal ganglia, attention, mood, anxiety, irritability
MeSH terms: Animals, Brain, Brain Mapping, Cognition, Dopamine, Humans, Personality, Receptors, Nicotinic, Smoking, Tobacco Use Disorder

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Functional brain imaging of tobacco use and dependence

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