The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Kinesin light chain -independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte
Abstract
Microtubules and the Kinesin heavy chain, the force-generating component of the plus end-directed microtubule motor Kinesin I are required for the localisation of oskar mRNA to the posterior pole of theDrosophila oocyte, an essential step in the determination of the anteroposterior axis. We show that the Kinesin heavy chain is also required for the posterior localisation of Dynein, and for all cytoplasmic movements within the oocyte. Furthermore, the KHC localises transiently to the posterior pole in an oskar mRNA-independent manner. Surprisingly, cytoplasmic streaming still occurs in kinesin light chain null mutants, and bothoskar mRNA and Dynein localise to the posterior pole. Thus, the Kinesin heavy chain can function independently of the light chain in the oocyte, indicating that it associates with its cargoes by a novel mechanism.
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Cites
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Cited by
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Kinesin Assembly and Movement in Cells
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JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation
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Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
(2026) · doi:10.1016/j.isci.2026.114875 · Cited by 5
Metadata
- Authors
- Palacios, I. M., & Johnston, D. S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-12-01
- Volume
- 129
- Issue
- 23
- Pages
- 5473-5485
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1985687970
- Cited by
- 190
- References
- 14
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
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