Kinesin Assembly and Movement in Cells

Verhey, Kristen J.; Kaul, Neha; Soppina, Virupakshi

doi:10.1146/annurev-biophys-042910-155310

Cited by 231Microtubule and mitosis dynamicsCellular Mechanics and InteractionsNuclear Structure and Function

Kinesin Assembly and Movement in Cells

Verhey, Kristen J., Kaul, Neha, Soppina, Virupakshi·2011·Annual Review of Biophysics

DOI 10.1146/annurev-biophys-042910-155310

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Abstract

Long-distance transport in eukaryotic cells is driven by molecular motors that move along microtubule tracks. Molecular motors of the kinesin superfamily contain a kinesin motor domain attached to family-specific sequences for cargo binding, regulation, and oligomerization. The biochemical and biophysical properties of the kinesin motor domain have been widely studied, yet little is known about how kinesin motors work in the complex cellular environment. We discuss recent studies on the three major families involved in intracellular transport (kinesin-1, kinesin-2, and kinesin-3) that have begun to bridge the gap in knowledge between the in vitro and in vivo behaviors of kinesin motors. These studies have increased our understanding of how kinesin subunits assemble to produce a functional motor, how kinesin motors are affected by biochemical cues and obstacles present on cellular microtubules, and how multiple motors on a cargo surface can work collectively for increased force production and travel distance.

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Kinesin family members are a class of motor proteins involved in cell movements and intracellular vesicles' trafficking from ER, and in chromosome and centrosome positioning during mitosis.
“a class of motor proteins involved in cell movements and intracellular vesicles’ trafficking from ER, and in chromosome and centrosome positioning during mitosis [66]”
From Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome (2018) · cites this paper as [66]

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Authors: Verhey, K. J., Kaul, N., & Soppina, V.
Affiliations: University of Michigan (US)
ORCID: Verhey, Kristen J.
Soppina, Virupakshi
Venue: Annual Review of Biophysics
Publisher: Annual Reviews
Published: 2011-06-09
Volume: 40
Issue: 1
Pages: 267-288
ISSN: 1936-122X (ISSN-L)
1936-1238
DOI: 10.1146/annurev-biophys-042910-155310
OpenAlex: W2124852145
Semantic Scholar: 21a1ae44a7ade38d091ac9effab6cca3e82c3508
Cited by: 231
References: 155
Citations by year: 2026: 10 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 29 · 2021: 21 · 2020: 17 · 2019: 15 · 2018: 20 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 16 · 2013: 14 · 2012: 19
FWCI: 1.48
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biophysics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM070862)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: kinesin, kinesin motor domain, kinesin-1, kinesin-2, kinesin-3, kinesin superfamily, intracellular transport, microtubule motor proteins, cargo binding, force generation, in vitro to in vivo translation
MeSH terms: Binding Sites, Cell Movement, Computer Simulation, Models, Biological, Models, Chemical, Protein Binding, Kinesins, Molecular Motor Proteins

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Kinesin Assembly and Movement in Cells

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