The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
Open accessAbstract
The mesencephalic dopamine (mesDA) system is involved in the control of movement and behavior. The expression of Pitx3 in the brain is restricted to the mesDA system and the gene is induced relatively late, at E11.5, a time when tyrosine hydroxylase (Th) gene expression is initiated. We show here that, in the Pitx3-deficient aphakia(ak) mouse mutant, the mesDA system is malformed. Owing to the developmental failure of mesDA neurons in the lateral field of the midbrain,mesDA neurons are not found in the SNc and the projections to the caudate putamen are selectively lost. However, Pitx3 is expressed in all mesDA neurons in control animals. Therefore, mesDA neurons react specifically to the loss of Pitx3. Defects of motor control where not seen in the ak mice,suggesting that other neuronal systems compensate for the absence of the nigrostriatal pathway. However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Biochemical Basis of Neuropharmacology.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-4-575_2 · Cited by 1,878
Schaeren-Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry · doi:10.1007/bf00267823 · Cited by 1,157
Dopamine Neuron Agenesis in Nurr1-Deficient Mice
Zetterström, R. H., Solomin, L., Jansson, L., Hoffer, B. J., Olson, L., & Perlmann, T. (1997) · Science · doi:10.1126/science.276.5310.248 · Cited by 1,092
FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate
Ye, W., Shimamura, K., Rubenstein, J. L. R., Hynes, M. A., & Rosenthal, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81437-3 · Cited by 879
Saucedo-Cardenas, O., Quintana-Hau, J. D., Le, W.-D., Smidt, M. P., Cox, J. J., De Mayo, F., Burbach, J. P. H., & Conneely, O. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4013 · Cited by 742
Self-citationPitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
Lin, C. R., Kioussi, C., O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisúa-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Nature · doi:10.1038/45803 · Cited by 612
Molecular Models for Vertebrate Limb Development
Johnson, R. L., & Tabin, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80364-5 · Cited by 580
Chen, H., Lun, Y., Ovchinnikov, D., Kokubo, H., Oberg, K. C., Pepicelli, C. V., Can, L., Lee, B., & Johnson, R. L. (1998) · Nature Genetics · doi:10.1038/ng0598-51 · Cited by 567
Complete coding sequence of rat tyrosine hydroxylase mRNA.
Grima, B., Lamouroux, A., Blanot, F., Biguet, N. F., & Mallet, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.617 · Cited by 533
Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome
Dreyer, S. D., Zhou, G., Baldini, A., Winterpacht, A., Zabel, B., Cole, W., Johnson, R. L., & Lee, B. (1998) · Nature Genetics · doi:10.1038/ng0598-47 · Cited by 530
Wurst, W., Auerbach, A. B., & Joyner, A. L. (1994) · Development · doi:10.1242/dev.120.7.2065 · Cited by 516
Hamers, F. P. T., Lankhorst, A. J., van Laar, T. J., Veldhuis, W. B., & Gispen, W. H. (2001) · Journal of Neurotrauma · doi:10.1089/08977150150502613 · Cited by 498
Self-citationInduction of midbrain dopaminergic neurons by Sonic hedgehog
Hynes, M., Porter, J. A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P. A., & Rosenthal, A. (1995) · Neuron · doi:10.1016/0896-6273(95)90062-4 · Cited by 482
Identification of a new brain-specific transcription factor, NURR1
Law, S. W. (1992) · Molecular Endocrinology · doi:10.1210/me.6.12.2129 · Cited by 400
Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2
Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B., & Joyner, A. L. (1995) · Science · doi:10.1126/science.7624797 · Cited by 398
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
Smidt, M. P., Asbreuk, C. H. J., Cox, J. J., Chen, H., Johnson, R. L., & Burbach, J. P. H. (2000) · Nature Neuroscience · doi:10.1038/73902 · Cited by 394
Self-citationFavor, J., Sandulache, R., Neuhäuser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Spörle, R., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13870 · Cited by 391
Pitx3 is required for development of substantia nigra dopaminergic neurons
Nunes, I., Tovmasian, L. T., Silva, R. M., Burke, R. E., & Goff, S. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0230529100 · Cited by 385
Smidt, M. P., van Schaick, H. S. A., Lanctôt, C., Tremblay, J. J., Cox, J. J., van der Kleij, A. A. M., Wolterink, G., Drouin, J., & Burbach, J. P. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13305 · Cited by 363
Self-citationFate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes
Simon, H. H., Saueressig, H., Wurst, W., Goulding, M. D., & O'Leary, D. D. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03126.2001 · Cited by 347
Hindlimb patterning and mandible development require the Ptx1 gene
Lanctôt, C., Moreau, A., Chamberland, M., Tremblay, M. L., & Drouin, J. (1999) · Development · doi:10.1242/dev.126.9.1805 · Cited by 311
Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
van den Munckhof, P., Luk, K. C., Ste-Marie, L., Montgomery, J., Blanchet, P. J., Sadikot, A. F., & Drouin, J. (2003) · Development · doi:10.1242/dev.00464 · Cited by 299
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development
Danielian, P. S., & McMahon, A. P. (1996) · Nature · doi:10.1038/383332a0 · Cited by 290
Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs
Grace, A. A., Bunney, B. S., Moore, H., & Todd, C. L. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10064-3 · Cited by 284
Hynes, M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A., & Rosenthal, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80344-x · Cited by 277
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
Hwang, D. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00162-1 · Cited by 257
Specification of dopaminergic and serotonergic neurons in the vertebrate CNS
Hynes, M., & Rosenthal, A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80004-x · Cited by 229
Semina, E. V., Reiter, R. S., & Murray, J. C. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.12.2109 · Cited by 218
Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice
Semina, E. V. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.11.1575 · Cited by 206
Suh, H., Gage, P. J., Drouin, J., & Camper, S. A. (2002) · Development · doi:10.1242/dev.129.2.329 · Cited by 202
Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain
Shamim, H., Mahmood, R., Logan, C., Doherty, P., Lumsden, A., & Mason, I. (1999) · Development · doi:10.1242/dev.126.5.945 · Cited by 199
Smits, S. M., Ponnio, T., Conneely, O. M., Burbach, J. P. H., & Smidt, M. P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02885.x · Cited by 194 · cited 2×
“MesDA neurons in Nurr1 knockout mice do not express Th, Dat (Slc6a3– Mouse Genome Informatics) and Vmat2(Slc18a2– Mouse Genome Informatics) (Smits et al., 2003) and are lost after initial generation (Zetterström et al.”
BackgroundSelf-citationMigration of dopaminergic neurons in the embryonic mesencephalon of mice
Kawano, H., Ohyama, K., Kawamura, K., & Nagatsu, I. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00018-9 · Cited by 163
Cooperation of Pax2 and Pax5 in midbrain and cerebellum development
Urbánek, P., Fetka, I., Meisler, M. H., & Busslinger, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5703 · Cited by 162
A Double-Deletion Mutation in the Pitx3 Gene Causes Arrested Lens Development in Aphakia Mice
Rieger, D. K., Reichenberger, E., McLean, W., Sidow, A., & Olsen, B. R. (2001) · Genomics · doi:10.1006/geno.2000.6464 · Cited by 145
Davidson, D. R., Graham, E., Sime, C., & Hill, R. E. (1988) · Development · doi:10.1242/dev.104.2.305 · Cited by 144
Hanaway, J., McConnell, J. A., & Netsky, M. G. (1971) · The Journal of Comparative Neurology · doi:10.1002/cne.901420105 · Cited by 120
Dopaminergic cells align along radial glia in the developing mesencephalon of the rat
Shults, C. W., Hashimoto, R., Brady, R. M., & Gage, F. H. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90039-7 · Cited by 106
Isthmic origin of neurons of the rat substantia nigra
Marchand, R., & POIRIER, L. J. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90300-7 · Cited by 101
Cazorla, P., Smidt, M. P., O’Malley, K. L., & Burbach, J. P. H. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741829.x · Cited by 92
Self-citationPitx3 activates mouse tyrosine hydroxylase promoter via a high‐affinity binding site
Lebel, M., Gauthier, Y., Moreau, A., & Drouin, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00257.x · Cited by 89
A Single Pitx1 Binding Site Is Essential for Activity of the LHβ Promoter in Transgenic Mice
Quirk, C. C., Lozada, K. L., Keri, R. A., & Nilson, J. H. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.5.0628 · Cited by 88 · cited 2×
“, 2002) and pituitary hormone regulation (Quirk et al., 2001; Quentien et al., 2002).”
BackgroundConserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development
Tucker, A. S., Khamis, A. A., Ferguson, C. A., Bach, I., Rosenfeld, M. G., & Sharpe, P. T. (1999) · Development · doi:10.1242/dev.126.2.221 · Cited by 68
Multiple calvarial defects inlmx1b mutant mice
Chen, H., Ovchinnikov, D. A., Pressman, C. L., Aulehla, A., Lun, Y., & Johnson, R. L. (1998) · Developmental Genetics · Cited by 50
Teitelman, G., Jaeger, C., Albert, V. R., Joh, T., & Dj, R. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01379.1983 · Cited by 37
Hall, A. C., Mira, H., Wagner, J., & Arenas, E. (2003) · Glia · doi:10.1002/glia.10229 · Cited by 36
Cited by
Piao, J., Zabierowski, S., Dubose, B. N., Hill, E. J., Navare, M., Claros, N., Rosen, S., Ramnarine, K., Horn, C., Fredrickson, C., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.004 · Cited by 240
Kee, N., Volakakis, N., Kirkeby, A., Dahl, L., Storvall, H., Nolbrant, S., Lahti, L., Björklund, Å. K., Gillberg, L., Joodmardi, E., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.10.003 · Cited by 149
Panman, L., Papathanou, M., Laguna, A., Oosterveen, T., Volakakis, N., Acampora, D., Kurtsdotter, I., Yoshitake, T., Kehr, J., Joodmardi, E., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.016 · Cited by 143
Currie, K. W., & Pearson, B. J. (2013) · Development · doi:10.1242/dev.098590 · Cited by 131
Development, wiring and function of dopamine neuron subtypes
Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00669-3 · Cited by 128
Metadata
- Authors
- Smidt, M. P., Smits, S. M., Bouwmeester, H., Hamers, F. P. T., van der Linden, A. J. A., Hellemons, A. J. C. G. M., Graw, J., & Burbach, J. P. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-03-01
- Volume
- 131
- Issue
- 5
- Pages
- 1145-1155
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2034564714
- Cited by
- 317
- References
- 46
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
