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PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
Open accessAbstract
PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity against selected pathogens and in female fertility. Here, we report that the infertility of Ptx3–/– mice is associated with severe abnormalities of the cumulus oophorus and failure of in vivo, but not in vitro, oocyte fertilization. PTX3 is produced by mouse cumulus cells during cumulus expansion and localizes in the matrix. PTX3 is expressed in the human cumulus oophorus as well. Cumuli from Ptx3–/– mice synthesize normal amounts of hyaluronan (HA), but are unable to organize it in a stable matrix. Exogenous PTX3 restores a normal cumulus phenotype. Incorporation in the matrix of inter-α-trypsin inhibitor is normal in Ptx3–/– cumuli. PTX3 does not interact directly with HA, but it binds the cumulus matrix hyaladherin tumor necrosis factor α-induced protein 6 (TNFAIP6, also known as TSG6) and thereby may form multimolecular complexes that can cross-link HA chains. Thus, PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility.
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Citations
Cited by
Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 836
Self-citationAn Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm
Bottazzi, B., Doni, A., Garlanda, C., & Mantovani, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101305 · Cited by 592
Self-citationJin, M., Fujiwara, E., Kakiuchi, Y., Okabe, M., Satouh, Y., Baba, S. A., Chiba, K., & Hirohashi, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018202108 · Cited by 422
TSG-6: A multifunctional protein with anti-inflammatory and tissue-protective properties
Day, A. J., & Milner, C. M. (2019) · Matrix Biology · doi:10.1016/j.matbio.2018.01.011 · Cited by 306
Self-citationDeficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis
Norata, G. D., Marchesi, P., Pulakazhi Venu, V. K., Pasqualini, F., Anselmo, A., Moalli, F., Pizzitola, I., Garlanda, C., Mantovani, A., & Catapano, A. L. (2009) · Circulation · doi:10.1161/circulationaha.108.806547 · Cited by 277
Self-citationWu, L. L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T.-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J., & Robker, R. L. (2015) · Development · doi:10.1242/dev.114850 · Cited by 276
Pentraxins as a key component of innate immunity
Bottazzi, B., Garlanda, C., Salvatori, G., Jeannin, P., Manfredi, A., & Mantovani, A. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.009 · Cited by 168
Self-citationTowards a Structure for a TSG-6·Hyaluronan Complex by Modeling and NMR Spectroscopy
Blundell, C. D., Almond, A., Mahoney, D. J., DeAngelis, P. L., Campbell, I. D., & Day, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414343200 · Cited by 73
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Metadata
- Authors
- Salustri, A., Garlanda, C., Hirsch, E., De Acetis, M., Maccagno, A., Bottazzi, B., Doni, A., Bastone, A., Mantovani, G., Peccoz, P. B., Salvatori, G., Mahoney, D. J., Day, A. J., Siracusa, G., Romani, L., & Mantovani, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-04-01
- Volume
- 131
- Issue
- 7
- Pages
- 1577-1586
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2170726898
- Cited by
- 446
- References
- 0
- FWCI
- 19.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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