The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
Abstract
In developing mammalian telencephalon, the loss of adherens junctions and cell cycle exit represent crucial steps in the differentiation of neuroepithelial cells into neurons, but the relationship between these cellular events remains obscure. Atypical protein kinase C (aPKC) is known to contribute to junction formation in epithelial cells and to cell fate determination for Drosophila neuroblasts. To elucidate the functions of aPKCλ, one out of two aPKC members, in mouse neocortical neurogenesis, a Nestin-Cre mediated conditional gene targeting system was employed. In conditional aPKCλ knockout mice, neuroepithelial cells of the neocortical region lost aPKCλ protein at embryonic day 15 and demonstrated a loss of adherens junctions, retraction of apical processes and impaired interkinetic nuclear migration that resulted in disordered neuroepithelial tissue architecture. These results are evidence that aPKCλ is indispensable for the maintenance of adherens junctions and may function in the regulation of adherens junction integrity upon differentiation of neuroepithelial cells into neurons. In spite of the loss of adherens junctions in the neuroepithelium of conditional aPKCλ knockout mice, neurons were produced at a normal rate. Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions.
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Cites
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The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Development and Evolution of the Human Neocortex
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N-cadherin mediates cortical organization in the mouse brain
Kadowaki, M., Nakamura, S., Machon, O., Krauss, S., Radice, G. L., & Takeichi, M. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.014 · Cited by 301
Cdk5rap2 exposes the centrosomal root of microcephaly syndromes
Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.007 · Cited by 124
Zhang, J., Shemezis, J. R., McQuinn, E. R., Wang, J., Sverdlov, M., & Chenn, A. (2013) · Neural Development · doi:10.1186/1749-8104-8-7 · Cited by 107
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Self-citationHuang, C., Liu, T., Wang, Q., Hou, W., Zhou, C., Song, Z., Shi, Y. S., Gao, X., Chen, G., Yin, Z., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa042 · Cited by 14
Metadata
- Authors
- Imai, F., Hirai, S.-I., Akimoto, K., Koyama, H., Miyata, T., Ogawa, M., Noguchi, S., Sasaoka, T., Noda, T., & Ohno, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-05-01
- Volume
- 133
- Issue
- 9
- Pages
- 1735-1744
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2147369750
- Cited by
- 178
- References
- 4
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
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