The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Pancreas and beta-cell development: from the actual to the possible
Abstract
The development of insulin-producing pancreatic beta (β)-cells represents the culmination of a complex developmental program. Cells of the posterior foregut assume a pancreatic identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a subset of these precursors becomes competent to generate β-cells. Postnatally, β-cells are primarily maintained by self-duplication rather than new differentiation. Although major gaps in our knowledge still persist, experiments across several organisms have shed increasing light on the steps of β-cell specification and differentiation. Increasing our understanding of the extrinsic, as well as intrinsic, mechanisms that control these processes should facilitate efforts to regenerate this important cell type in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 4,859
Massagué, J., Seoane, J., & Wotton, D. (2005) · Genes & Development · doi:10.1101/gad.1350705 · Cited by 2,452
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D'Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O. G., Agulnick, A. D., Smart, N. G., Moorman, M. A., Kroon, E., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,915
Efficient differentiation of human embryonic stem cells to definitive endoderm
D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730
Gu, G., Dubauskaite, J., & Melton, D. A. (2002) · Development · doi:10.1242/dev.129.10.2447 · Cited by 1,518
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,513
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
Gradwohl, G., Dierich, A., LeMeur, M., & Guillemot, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1607 · Cited by 1,439
A common progenitor for neurons and glia persists in rat retina late in development
Turner, D. L., & Cepko, C. L. (1987) · Nature · doi:10.1038/328131a0 · Cited by 1,421
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
Cabrera, O., Berman, D. M., Kenyon, N. S., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510790103 · Cited by 1,312
Cited by
Murry, C. E., & Keller, G. (2008) · Cell · doi:10.1016/j.cell.2008.02.008 · Cited by 1,729
Baron, M., Veres, A., Wolock, S. L., Faust, A. L., Gaujoux, R., Vetere, A., Ryu, J. H., Wagner, B. K., Shen-Orr, S. S., Klein, A. M., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.011 · Cited by 1,508
Vertebrate Endoderm Development and Organ Formation
Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812
Development of the Human Pancreas From Foregut to Endocrine Commitment
Jennings, R. E., Berry, A. A., Kirkwood-Wilson, R., Roberts, N. A., Hearn, T., Salisbury, R. J., Blaylock, J., Piper Hanley, K., & Hanley, N. A. (2013) · Diabetes · doi:10.2337/db12-1479 · Cited by 310
Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation
Zaret, K. S. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2318 · Cited by 290
Approaching the in vitro clinical trial: engineering organs on chips
Capulli, A. K., Tian, K., Mehandru, N., Bukhta, A., Choudhury, S. F., Suchyta, M., & Parker, K. K. (2014) · Lab on a Chip · doi:10.1039/c4lc00276h · Cited by 111
Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas
Szabat, M., Lynn, F. C., Hoffman, B. G., Kieffer, T. J., Allan, D. W., & Johnson, J. D. (2012) · Diabetes · doi:10.2337/db11-1361 · Cited by 68
Employing core regulatory circuits to define cell identity
Almeida, N., Chung, M. W. H., Drudi, E. M., Engquist, E. N., Hamrud, E., Isaacson, A., Tsang, V. S. K., Watt, F. M., & Spagnoli, F. M. (2021) · The EMBO Journal · doi:10.15252/embj.2020106785 · Cited by 49
Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
Jiang, Y., Nishimura, W., Devor-Henneman, D., Kusewitt, D., Wang, H., Holloway, M. P., Dohi, T., Sabo, E., Robinson, M. L., Altieri, D. C., et al. (2008) · Diabetes · doi:10.2337/db08-0170 · Cited by 38
Development of insulin-producing cells from primitive biologic precursors
Evans-Molina, C., Vestermark, G. L., & Mirmira, R. G. (2009) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283186fc1 · Cited by 18
Metadata
- Authors
- Murtaugh, L. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-02-01
- Volume
- 134
- Issue
- 3
- Pages
- 427-438
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2091152603
- Cited by
- 289
- References
- 159
- FWCI
- 24.31
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
