Approaching the in vitro clinical trial: engineering organs on chips
Open accessAbstract
In vitro cell culture and animal models are the most heavily relied upon tools of the pharmaceutical industry. When these tools fail, the results are costly and have at times, proven deadly. One promising new tool to enhance preclinical development of drugs is Organs on Chips (OOCs), proposed as a clinically and physiologically relevant means of modeling health and disease. Bringing the patient from bedside to bench in this form requires that the design, build, and test of OOCs be founded in clinical observations and methods. By creating OOCs as models of the patient, the industry may be better positioned to evaluate medicinal therapeutics.
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- Authors
- Capulli, A. K., Tian, K., Mehandru, N., Bukhta, A., Choudhury, S. F., Suchyta, M., & Parker, K. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Parker, K. K.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014-05-15
- Volume
- 14
- Issue
- 17
- Pages
- 3181
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC4117800
- OpenAlex
- W2125370350
- Cited by
- 111
- References
- 54
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 20 · 2016: 14 · 2015: 10 · 2014: 4
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UH3TR000522)
- Harvard School of Engineering and Applied Sciences
- Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University
- National Cancer Institute (R01CA080728)
- National Institute of Neurological Disorders and Stroke (UH2 NS080728-01)
- National Center for Advancing Translational Sciences
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- organ-on-a-chip, preclinical drug development, disease modeling, patient modeling, in vitro cell culture, animal models, translational research, treatment evaluation
- MeSH terms
- Artificial Organs, Clinical Trials as Topic, Humans, Patient Simulation, Lab-On-A-Chip Devices, In Vitro Techniques
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