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Pancreas and beta-cell development: from the actual to the possible

Murtaugh, L. Charles·2007·Development

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Abstract

The development of insulin-producing pancreatic beta (β)-cells represents the culmination of a complex developmental program. Cells of the posterior foregut assume a pancreatic identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a subset of these precursors becomes competent to generate β-cells. Postnatally, β-cells are primarily maintained by self-duplication rather than new differentiation. Although major gaps in our knowledge still persist, experiments across several organisms have shed increasing light on the steps of β-cell specification and differentiation. Increasing our understanding of the extrinsic, as well as intrinsic, mechanisms that control these processes should facilitate efforts to regenerate this important cell type in humans.

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Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
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Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
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The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein.
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The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the α-and β-cell lineages in the mouse endocrine pancreas
Collombat, P., Hecksher-Sørensen, J., Broccoli, V., Krull, J., Ponte, I., Mundiger, T., Smith, J., Gruss, P., Serup, P., & Mansouri, A. (2005) · Development · doi:10.1242/dev.01870 · Cited by 227
The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic β cells and intestinal endocrine cells
Gierl, M. S., Karoulias, N., Wende, H., Strehle, M., & Birchmeier, C. (2006) · Genes & Development · doi:10.1101/gad.381806 · Cited by 217
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
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TGF-β1 influences the relative development of the exocrine and endocrine pancreas in vitro
Sanvito, F., Herrera, P.-L., Huarte, J., Nichols, A., Montesano, R., Orci, L., & Vassalli, J.-D. (1994) · Development · doi:10.1242/dev.120.12.3451 · Cited by 216
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
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Transcriptional networks controlling pancreatic development and beta cell function
Servitja, J. M., & Ferrer, J. (2004) · Diabetologia · doi:10.1007/s00125-004-1368-9 · Cited by 215
FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
Norgaard, G. A., Jensen, J. N., & Jensen, J. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.08.013 · Cited by 214
Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas
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“This result suggests that endogenous activin-family ligands normally promote endocrine development; consistent with this hypothesis, the developing pancreata of mice that lack the type IIB activin receptor have severely reduced islet mass, but apparently normal acinar tissue (Kim et al., 2000).”
Result
Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development
Molotkov, A., Molotkova, N., & Duester, G. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20256 · Cited by 212
vhnf1 , the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain
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Foxa2 is required for the differentiation of pancreatic α-cells
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TGF-β signals and a prepattern in Xenopus laevis endodermal development
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FGF signaling is necessary for establishing gut tube domains alongthe anterior–posterior axis in vivo
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PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance
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Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice
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Genetic determinants of pancreatic ε-cell development
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IA1 is NGN3‐dependent and essential for differentiation of the endocrine pancreas
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The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
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Formation of the definitive endoderm in mouse is a Smad2-dependent process
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An Endocrine-Exocrine Switch in the Activity of the Pancreatic Homeodomain Protein PDX1 through Formation of a Trimeric Complex with PBX1b and MRG1 (MEIS2)
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Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus
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The Cut-Homeodomain Transcriptional Activator HNF-6 Is Coexpressed with Its Target Gene HNF-3β in the Developing Murine Liver and Pancreas
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Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of β-Cells in the Adult Pancreas
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GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development
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The Transcription Factor Hepatocyte Nuclear Factor-6 Controls the Development of Pancreatic Ducts in the Mouse
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Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
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Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas.
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The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation
Wang, J., Elghazi, L., Parker, S. E., et al. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.10.018 · Cited by 151
HNF-6 Is Expressed in Endoderm Derivatives and Nervous System of the Mouse Embryo and Participates to the Cross-Regulatory Network of Liver-Enriched Transcription Factors
Landry, C., Clotman, F., Hioki, T., Oda, H., Picard, J. J., Lemaigre, F. P., & Rousseau, G. G. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8757 · Cited by 148
The FoxM1 Transcription Factor Is Required to Maintain Pancreatic β-Cell Mass
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Retinoic Acid Induces Pdx1-Positive Endoderm in Differentiating Mouse Embryonic Stem Cells
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Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
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Autonomous Endodermal Determination in Xenopus: Regulation of Expression of the Pancreatic Gene XlHbox 8
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Specifying pancreatic endocrine cell fates
Collombat, P., Hecksher‐Sørensen, J., Serup, P., & Mansouri, A. (2006) · Mechanisms of Development · doi:10.1016/j.mod.2006.05.006 · Cited by 132
Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes
Stiles, B. L., Kuralwalla-Martinez, C., Guo, W., Gregorian, C., Wang, Y., Tian, J., Magnuson, M. A., & Wu, H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2772-2781.2006 · Cited by 131
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
Fujikura, J., Hosoda, K., Iwakura, H., Tomita, T., Noguchi, M., Masuzaki, H., Tanigaki, K., Yabe, D., Honjo, T., & Nakao, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.12.005 · Cited by 121
Pancreatic Islet Transplantation
Naftanel, M. A., & Harlan, D. M. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010058 · Cited by 120
Neurogenin3 and Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4
Smith, S. B., Gasa, R., Watada, H., Wang, J., Griffen, S. C., & German, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302229200 · Cited by 119
Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue.Preprint
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Regeneration of Pancreatic Islets After Partial Pancreatectomy in Mice Does Not Involve the Reactivation of Neurogenin-3
Lee, C. S., León, D. D. D., Kaestner, K. H., & Stoffers, D. A. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1300 · Cited by 114
Reversal of Diabetes in Non-Obese Diabetic Mice Without Spleen Cell-Derived ß Cell Regeneration
Chong, A. S., Shen, J., Tao, J., Yin, D., Kuznetsov, A., Hara, M., & Philipson, L. H. (2006) · Science · doi:10.1126/science.1123510 · Cited by 110
Islet Recovery and Reversal of Murine Type 1 Diabetes in the Absence of Any Infused Spleen Cell Contribution
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The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation
Duvillié, B., Attali, M., Bounacer, A., Ravassard, P., Basmaciogullari, A., & Scharfmann, R. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0839 · Cited by 109
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Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish
Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdóttir, E., Gnügge, L., Bortolussi, M., Driever, W., & Argenton, F. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.041 · Cited by 102
In vitro transdifferentiation of hepatoma cells into functional pancreatic cells
Li, W., Horb, M. E., Tosh, D., & Slack, J. M. W. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.01.001 · Cited by 102
Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas
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Involvement of the Homeodomain-Containing Transcription Factor PDX-1 in Islet Amyloid Polypeptide Gene Transcription
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Identification of cis- and trans-Active Factors Regulating Human Islet Amyloid Polypeptide Gene Expression in Pancreatic β-Cells
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Distinct Gene Expression Programs Function in Progenitor and Mature Islet Cells
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Dorsal Pancreas Agenesis in N-Cadherin- Deficient Mice
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Interplay between FGF10 and Notch signalling is required for the self-renewal of pancreatic progenitors
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Vertebrate Endoderm Development and Organ Formation
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Development of the Human Pancreas From Foregut to Endocrine Commitment
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See all 289

Authors: Murtaugh, L. C.
Venue: Development
Publisher: The Company of Biologists
Published: 2007-02-01
Volume: 134
Issue: 3
Pages: 427-438
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.02770
OpenAlex: W2091152603
Cited by: 289
References: 159
FWCI: 24.31
Type: journal article
Language: en
Open access: closed

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Pancreas and beta-cell development: from the actual to the possible

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