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Sphingosine 1-phosphate signalling
Open accessAbstract
Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.
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Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
Kappos, L., Radue, E.-W., O'Connor, P., Polman, C., Hohlfeld, R., Calabresi, P., Selmaj, K., Agoropoulou, C., Leyk, M., Zhang-Auberson, L., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909494 · Cited by 2,644
Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
Cohen, J. A., Barkhof, F., Comi, G., Hartung, H.-P., Khatri, B. O., Montalban, X., Pelletier, J., Capra, R., Gallo, P., Izquierdo, G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907839 · Cited by 2,204
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
Mandala, S., Hajdu, R., Bergstrom, J., Quackenbush, E., Xie, J., Milligan, J., Thornton, R., Shei, G.-J., Card, D., Keohane, C., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,690
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E., Baumruker, T., Hiestand, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200176200 · Cited by 1,504
Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C.-X., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,149
Self-citationLee, M.-J., Thangada, S., Claffey, K. P., Ancellin, N., Liu, C. H., Kluk, M., Volpi, M., Sha'afi, R. I., & Hla, T. (1999) · Cell · doi:10.1016/s0092-8674(00)81661-x · Cited by 1,013
Self-citationRegulation of histone acetylation in the nucleus by sphingosine-1-phosphate
Hait, N. C., Allegood, J., Maceyka, M., Strub, G. M., Harikumar, K. B., Singh, S. K., Luo, C., Marmorstein, R., Kordula, T., Milstien, S., et al. (2009) · Science · doi:10.1126/science.1176709 · Cited by 997
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y.-W., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 877
Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs
Cyster, J. G., & Schwab, S. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075011 · Cited by 815
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Alvarez, S. E., Harikumar, K. B., Hait, N. C., Allegood, J., Strub, G. M., Kim, E. Y., Maceyka, M., Jiang, H., Luo, C., Kordula, T., et al. (2010) · Nature · doi:10.1038/nature09128 · Cited by 752
Essential Role for Sphingosine Kinases in Neural and Vascular Development
Mizugishi, K., Yamashita, T., Olivera, A., Miller, G. F., Spiegel, S., & Proia, R. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11113-11121.2005 · Cited by 742
Massberg, S., Schaerli, P., Knezevic-Maramica, I., Köllnberger, M., Tubo, N., Moseman, E. A., Huff, I. V., Junt, T., Wagers, A. J., Mazo, I. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.047 · Cited by 696
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
Rosen, H., & Goetzl, E. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1650 · Cited by 694
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
Christoffersen, C., Obinata, H., Kumaraswamy, S. B., Galvani, S., Ahnström, J., Sevvana, M., Egerer-Sieber, C., Muller, Y. A., Hla, T., Nielsen, L. B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103187108 · Cited by 598
Self-citationInternational Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature
Chun, J., Goetzl, E. J., Hla, T., Igarashi, Y., Lynch, K. R., Moolenaar, W., Pyne, S., & Tigyi, G. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.265 · Cited by 464
Self-citationPham, T. H. M., Baluk, P., Xu, Y., Grigorova, I., Bankovich, A. J., Pappu, R., Coughlin, S. R., McDonald, D. M., Schwab, S. R., & Cyster, J. G. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091619 · Cited by 444
Pham, T. H. M., Okada, T., Matloubian, M., Lo, C. G., & Cyster, J. G. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.017 · Cited by 427
Kono, M., Mi, Y., Liu, Y., Sasaki, T., Allende, M. L., Wu, Y.-P., Yamashita, T., & Proia, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403937200 · Cited by 415
Oo, M. L., Thangada, S., Wu, M.-T., Liu, C. H., Macdonald, T. L., Lynch, K. R., Lin, C.-Y., & Hla, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610318200 · Cited by 405
Self-citationThe Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A., & Mochizuki, N. (2009) · Science · doi:10.1126/science.1167449 · Cited by 405
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
Kupperman, E., An, S., Osborne, N., Waldron, S., & Stainier, D. Y. R. (2000) · Nature · doi:10.1038/35018092 · Cited by 394
Strub, G. M., Paillard, M., Liang, J., Gomez, L., Allegood, J. C., Hait, N. C., Maceyka, M., Price, M. M., Chen, Q., Simpson, D. C., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-167502 · Cited by 379
Windh, R. T., Lee, M.-J., Hla, T., An, S., Barr, A. J., & Manning, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27351 · Cited by 333
Self-citationChun, J., Hla, T., Lynch, K. R., Spiegel, S., & Moolenaar, W. H. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003111 · Cited by 330
Self-citationFukuhara, S., Simmons, S., Kawamura, S., Inoue, A., Orba, Y., Tokudome, T., Sunden, Y., Arai, Y., Moriwaki, K., Ishida, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60746 · Cited by 324
Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development
Jung, B., Obinata, H., Galvani, S., Mendelson, K., Ding, B.-S., Skoura, A., Kinzel, B., Brinkmann, V., Rafii, S., Evans, T., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.07.015 · Cited by 317
Self-citationGaengel, K., Niaudet, C., Hagikura, K., Laviña, B., Muhl, L., Hofmann, J. J., Ebarasi, L., Nyström, S., Rymo, S., Chen, L. L., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.08.005 · Cited by 317
LaMontagne, K., Littlewood-Evans, A., Schnell, C., O'Reilly, T., Wyder, L., Sanchez, T., Probst, B., Butler, J., Wood, A., Liau, G., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2001 · Cited by 295
Self-citationLee, M.-J., Thangada, S., Paik, J.-H., Sapkota, G. P., Ancellin, N., Chae, S.-S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00324-0 · Cited by 291
Self-citationPaik, J. H., Chae, S.-S., Lee, M.-J., Thangada, S., & Hla, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009422200 · Cited by 286
Self-citationSphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization
Paik, J.-H., Skoura, A., Chae, S.-S., Cowan, A. E., Han, D. K., Proia, R. L., & Hla, T. (2004) · Genes & Development · doi:10.1101/gad.1227804 · Cited by 278
Self-citationSugimoto, N., Takuwa, N., Okamoto, H., Sakurada, S., & Takuwa, Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.5.1534-1545.2003 · Cited by 264
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Saba, J. D., & Hla, T. (2004) · Circulation Research · doi:10.1161/01.res.0000122383.60368.24 · Cited by 260
Self-citationNon-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
Kingsbury, M. A., Rehen, S. K., Contos, J. J. A., Higgins, C., & Chun, J. J. M. (2003) · Nature Neuroscience · doi:10.1038/nn1157 · Cited by 254
Engagement of S1P1-degradative mechanisms leads to vascular leak in mice
Oo, M. L., Chang, S.-H., Thangada, S., Wu, M.-T., Rezaul, K., Blaho, V. A., Hwang, S., Han, D. K. M., & Hla, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45403 · Cited by 225
Self-citationFunctions of the Multifaceted Family of Sphingosine Kinases and Some Close Relatives
Spiegel, S., & Milstien, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r600028200 · Cited by 219
Ryu, Y., Takuwa, N., Sugimoto, N., Sakurada, S., Usui, S., Okamoto, H. H., Matsui, O., & Takuwa, Y. (2002) · Circulation Research · doi:10.1161/hh0302.104455 · Cited by 219
Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient
Venkataraman, K., Thangada, S., Michaud, J., Oo, M. L., Ai, Y., Lee, Y.-M., Wu, M., Parikh, N. S., Khan, F., Proia, R. L., et al. (2006) · Biochemical Journal · doi:10.1042/bj20060251 · Cited by 202
Self-citationGeneration and metabolism of bioactive sphingosine‐1‐phosphate
Stunff, H. L., Milstien, S., & Spiegel, S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20097 · Cited by 201
The vascular S1P gradient—Cellular sources and biological significance
HLA, T. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.07.003 · Cited by 180
Self-citationSphingosine 1-phosphate in coagulation and inflammation
Obinata, H., & Hla, T. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0287-3 · Cited by 174
Self-citationThe Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish
Osborne, N., Brand-Arzamendi, K., Ober, E. A., Jin, S.-W., Verkade, H., Holtzman, N. G., Yelon, D., & Stainier, D. Y. R. (2008) · Current Biology · doi:10.1016/j.cub.2008.10.061 · Cited by 167
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning
Escalante‐Alcalde, D., Hernandez, L. F., Stunff, H. L., Maeda, R., Lee, H., Cheng, G., Sciorra, V. A., Daar, I. O., Spiegel, S., Morris, A. J., et al. (2003) · Development · doi:10.1242/dev.00635 · Cited by 167
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
Sánchez, T., Thangada, S., Wu, M.-T., Kontos, C. D., Wu, D., Wu, H., & Hla, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409784102 · Cited by 160
Self-citationBlaho, V. A., & Hla, T. (2011) · Chemical Reviews · doi:10.1021/cr200273u · Cited by 151
Self-citationLysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus
Yung, Y. C., Mutoh, T., Lin, M., Noguchi, K., Rivera, R. R., Choi, J. W., Kingsbury, M. A., & Chun, J. J. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002095 · Cited by 142
Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation
Michaud, J. E., Im, D., & Hla, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901586 · Cited by 129
Self-citationS1P1 inhibits sprouting angiogenesis during vascular development
Shoham, A. B., Malkinson, G., Krief, S., Shwartz, Y., Ely, Y., Ferrara, N., Yaniv, K., & Zelzer, E. (2012) · Development · doi:10.1242/dev.078550 · Cited by 116
Lipid phosphate phosphatase 3 enables efficient thymic egress
Bréart, B., Ramos-Pérez, W. D., Mendoza, A., Salous, A. K., Gobert, M., Huang, Y., Adams, R. H., Lafaille, J. J., Escalante‐Alcalde, D., Morris, A. J., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102551 · Cited by 109
Edsbagge, J., Johansson, J. K., Esni, F., Luo, Y., Radice, G. L., & Semb, H. (2005) · Development · doi:10.1242/dev.01643 · Cited by 77
Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning
Mendelson, K., Zygmunt, T., Torres‐Vázquez, J., Evans, T., & Hla, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.427344 · Cited by 73
Self-citationChae, S., Paik, J., Allende, M. L., Proia, R. L., & Hla, T. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.01.001 · Cited by 72
Self-citationS1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence
Ding, Y., & Lin, F. H. (2013) · Development · doi:10.1242/dev.085340 · Cited by 51
Kai, M., Heisenberg, C., & Tada, M. (2008) · Development · doi:10.1242/dev.020396 · Cited by 41
Serafimidis, I., Heximer, S. P., Beis, D., & Gavalas, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05702-11 · Cited by 32
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Metadata
- Authors
- Mendelson, K., Evans, T., & Hla, T.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-01-01
- Volume
- 141
- Issue
- 1
- Pages
- 5-9
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2099792211
- Cited by
- 309
- References
- 57
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
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