The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Identification of the zebrafish maternal and paternal transcriptomes
Open accessAbstract
Transcription is an essential component of basic cellular and developmental processes. However, early embryonic development occurs in the absence of transcription and instead relies upon maternal mRNAs and proteins deposited in the egg during oocyte maturation. Although the early zebrafish embryo is competent to transcribe exogenous DNA, factors present in the embryo maintain genomic DNA in a state that is incompatible with transcription. The cell cycles of the early embryo titrate out these factors, leading to zygotic transcription initiation, presumably in response to a change in genomic DNA chromatin structure to a state that supports transcription. To understand the molecular mechanisms controlling this maternal to zygotic transition, it is important to distinguish between the maternal and zygotic transcriptomes during this period. Here we use exome sequencing and RNA-seq to achieve such discrimination and in doing so have identified the first zygotic genes to be expressed in the embryo. Our work revealed different profiles of maternal mRNA post-transcriptional regulation prior to zygotic transcription initiation. Finally, we demonstrate that maternal mRNAs are required for different modes of zygotic transcription initiation, which is not simply dependent on the titration of factors that maintain genomic DNA in a transcriptionally incompetent state.
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Cites
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Landscape of transcription in human cells
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The zebrafish reference genome sequence and its relationship to the human genome.
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Self-citationTranscription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227
RNA sequencing: advances, challenges and opportunities
Ozsolak, F., & Milos, P. M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2934 · Cited by 2,135 · cited 1×
“Recently, new sequencing technologies have significantly improved our ability to analyse transcription (Ozsolak and Milos, 2011; Collins et al., 2012; Djebali et al., 2012).”
BackgroundZebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
Genotype and SNP calling from next-generation sequencing data
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A major developmental transition in early xenopus embryos: II. control of the onset of transcription
Newport, J., & Kirschner, M. (1982) · Cell · doi:10.1016/0092-8674(82)90273-2 · Cited by 1,055
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Cited by
Mechanisms regulating zygotic genome activation
Schulz, K. N., & Harrison, M. M. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0087-x · Cited by 555
Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
Lee, M. T., Bonneau, A. R., Takacs, C. M., Bazzini, A. A., DiVito, K. R., Fleming, E. S., & Giraldez, A. J. (2013) · Nature · doi:10.1038/nature12632 · Cited by 503
The maternal-to-zygotic transition revisited
Vastenhouw, N. L., Cao, W. X., & Lipshitz, H. D. (2019) · Development · doi:10.1242/dev.161471 · Cited by 445
A high-resolution mRNA expression time course of embryonic development in zebrafish
White, R. J., Collins, J. E., Sealy, I. M., Wali, N., Dooley, C. M., Digby, Z., Stemple, D. L., Murphy, D. N., Billis, K., Hourlier, T., et al. (2017) · eLife · doi:10.7554/elife.30860 · Cited by 361
Self-citationNepal, C., Hadzhiev, Y., Balwierz, P., Tarifeño-Saldivia, E., Cardenas, R., Wragg, J. W., Suzuki, A.-M., Carninci, P., Peers, B., Lenhard, B., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13687-0 · Cited by 52
Metadata
- Authors
- Harvey, S. A., Sealy, I., Kettleborough, R., Fenyes, F., White, R., Stemple, D., & Smith, J. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2013-07-01
- Volume
- 140
- Issue
- 13
- Pages
- 2703-2710
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2098218231
- Cited by
- 204
- References
- 10
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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