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A two-step model for the localization of maternal mRNA in Xenopus oocytes: Involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA
Abstract
In an effort to understand how polarity is established in Xenopus oocytes, we have analyzed the process of localization of the maternal mRNA, vg1. In fully grown oocytes, vg1 mRNA is tightly localized at the vegetal cortex. Biochemical fractionation shows that the mRNA is preferentially associated with a detergent-insoluble subcellular fraction. The use of cytoskeletal inhibitors suggests that (1) microtubules are involved in the translocation of the message to the vegetal hemisphere and (2) microfilaments are important for the anchoring of the message at the cortex. Furthermore, immunohistochemistry reveals that a cytoplasmic microtubule array exists during translocation. These results suggest a role for the cytoskeleton in localizing information in the oocyte.
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Citations
Cited by
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Martin, K. C., & Ephrussi, A. (2009) · Cell · doi:10.1016/j.cell.2009.01.044 · Cited by 1,048
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Ross, A. F., Oleynikov, Y., Kislauskis, E. H., Taneja, K. L., & Singer, R. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2158 · Cited by 561
Ostroff, L. E., Fiala, J. C., Allwardt, B., & Harris, K. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00785-7 · Cited by 461
Wordeman, L., & Mitchison, T. J. (1995) · The Journal of cell biology · doi:10.1083/jcb.128.1.95 · Cited by 382
RNA LOCALIZATION IN DEVELOPMENT
Bashirullah, A., Cooperstock, R. L., & Lipshitz, H. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.335 · Cited by 339
De-centralizing the Central Dogma: mRNA translation in space and time
Bourke, A. M., Schwarz, A., & Schuman, E. M. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.030 · Cited by 106
Behar, L., Marx, R., Sadot, E., Barg, J., & Ginzburg, I. (1995) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(95)00001-w · Cited by 85
Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling
Latinkic, B. V., Mercurio, S., Bennett, B., Hirst, E. M. A., Xu, Q., Lau, L. F., Mohun, T. J., & Smith, J. C. (2003) · Development · doi:10.1242/dev.00449 · Cited by 77
Metadata
- Authors
- Yisraeli, J. K., Sokol, S., & Melton, D. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1990-02-01
- Volume
- 108
- Issue
- 2
- Pages
- 289-298
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2118093120
- Cited by
- 391
- References
- 0
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- closed
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