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Cited by 106RNA and protein synthesis mechanismsRNA Research and SplicingPI3K/AKT/mTOR signaling in cancer

De-centralizing the Central Dogma: mRNA translation in space and time

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Bourke, Ashley M., Schwarz, Andre, Schuman, Erin M.·2023·Molecular Cell
DOI 10.1016/j.molcel.2022.12.030
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Abstract

As our understanding of the cell interior has grown, we have come to appreciate that most cellular operations are localized, that is, they occur at discrete and identifiable locations or domains. These cellular domains contain enzymes, machines, and other components necessary to carry out and regulate these localized operations. Here, we review these features of one such operation: the localization and translation of mRNAs within subcellular compartments observed across cell types and organisms. We describe the conceptual advantages and the "ingredients" and mechanisms of local translation. We focus on the nature and features of localized mRNAs, how they travel and get localized, and how this process is regulated. We also evaluate our current understanding of protein synthesis machines (ribosomes) and their cadre of regulatory elements, that is, the translation factors.

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  • The dynamic association of RBPs with mRNA monitors the localization of mRNA, including its movements between actively translating ribosomes, stress granules, and p bodies in a context-dependent manner.

    “Furthermore, the dynamic association of RBPs with mRNA monitors the localization of mRNA, in particular its movements between actively translating ribosomes, stress granules, and p bodies in a context-dependent manner [42].”

    From Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis (2024) · cites this paper as [42]

    The ‘Ingredients and mechanisms for local translation’ section (page not provided) says that dynamic RBP–mRNA association regulates mRNA transport and translation, and that RBP-dependent localization is context-dependent. It identifies stress granules and P-bodies as associated with translationally repressed mRNA, but does not describe RBP association monitoring mRNA movements between those granules and actively translating ribosomes. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • RBPs monitor mRNA stability and decay and control the correct translation of mRNA.

    “RBPs monitor mRNA stability and decay and control the correct translation of mRNA.”

    From Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis (2024) · cites this paper as [42]

  • The transport function of RBPs can be mediated either by their direct binding to motor proteins or indirectly through motor protein cargo adaptors.

    “The transport function of RBPs can be mediated either by their direct binding to motor proteins or, indirectly, through motor protein cargo adaptors [42].”

    From Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis (2024) · cites this paper as [42]

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Cited by

Sorted by citations

Authors
Bourke, A. M., Schwarz, A., & Schuman, E. M.
Affiliations
Max Planck Institute for Brain Research (DE)
Corresponding author
Schuman, Erin M.
ORCID
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2023-02
Volume
83
Issue
3
Pages
452-468
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2022.12.030
OpenAlex
W4317690428
Cited by
106
References
8
Citations by year
2026: 33 · 2025: 42 · 2024: 21 · 2023: 10
FWCI
2.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • European Commission
  • Max-Planck-Gesellschaft
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
mRNA localization, local translation, subcellular compartments, ribosome, translation factors, protein synthesis, translational regulation, mRNA transport
MeSH terms
Ribosomes, RNA, Messenger, Protein Biosynthesis

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