The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Developmental expression of two murine fibroblast growth factor receptors, fig and bek
Abstract
Developmental expression of two closely related fibroblast growth factor receptors, bek and fig, is described from early postimplantation until advanced organogenesis. Transcripts of bek and fig were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
Self-citation
Cited by
Multipotent cell lineages in early mouse development depend on SOX2 function
Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N., & Lovell-Badge, R. (2003) · Genes & Development · doi:10.1101/gad.224503 · Cited by 2,369
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,519
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth
Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,070
Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome
Wilkie, A. O. M., Slaney, S. F., Oldridge, M., Poole, M. D., Ashworth, G. J., Hockley, A. D., Hayward, R. D., David, D. J., Pulleyn, L. J., Rutland, P., et al. (1995) · Nature Genetics · doi:10.1038/ng0295-165 · Cited by 935
Ornitz, D. M., & Marie, P. J. (2002) · Genes & Development · doi:10.1101/gad.990702 · Cited by 905
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904
Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome
Reardon, W., Winter, R. M., Rutland, P., Pulleyn, L. J., Jones, B. M., & Malcolm, S. (1994) · Nature Genetics · doi:10.1038/ng0994-98 · Cited by 758
The roles of FGFs in the early development of vertebrate limbs
Martin, G. R. (1998) · Genes & Development · doi:10.1101/gad.12.11.1571 · Cited by 648
Xu, X., Weinstein, M., Li, C., Naski, M., Cohen, R. I., Ornitz, D. M., Leder, P., & Deng, C. (1998) · Development · doi:10.1242/dev.125.4.753 · Cited by 553
Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D., & Hurley, M. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8641 · Cited by 483
Yan, G., Fukabori, Y., McBride, G., Nikolaropolous, S., & McKeehan, W. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4513 · Cited by 403
FGF-4 and BMP-2 have opposite effects on limb growth
Niswander, L., & Martin, G. R. (1993) · Nature · doi:10.1038/361068a0 · Cited by 377
Celli, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1642 · Cited by 375
FGF signaling in the developing endochondral skeleton
Ornitz, D. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.003 · Cited by 356
Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme
Dudley, A. T., Godin, R. E., & Robertson, E. J. (1999) · Genes & Development · doi:10.1101/gad.13.12.1601 · Cited by 320
Fibroblast-growth-factor receptor mutations in human skeletal disorders
Muenke, M., & Schell, U. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89088-5 · Cited by 295
The eed mutation disrupts anterior mesoderm production in mice
Faust, C., Schumacher, A., Holdener, B., & Magnuson, T. (1995) · Development · doi:10.1242/dev.121.2.273 · Cited by 294
Kettunen, P., & Thesleff, I. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199803)211:3<256::aid-aja7>3.0.co;2-g · Cited by 275
Fibroblast growth factor signaling controlling osteoblast differentiation
Marie, P. J. (2003) · Gene · doi:10.1016/s0378-1119(03)00748-0 · Cited by 274
Fibroblast Growth Factors In The Developing Central Nervous System
Ford‐Perriss, M., Abud, H., & Murphy, M. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03477.x · Cited by 264
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
Mudò, G., Bonomo, A., Di Liberto, V., Frinchi, M., Fuxe, K., & Belluardo, N. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0207-z · Cited by 158
FGF signaling is required for anterior but not posterior specification of the murine liver bud
Wang, J., Rhee, S., Palaria, A., & Tremblay, K. D. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24215 · Cited by 40
Metadata
- Authors
- Orr-Urtreger, A., Givol, D., Yayon, A., Yarden, Y., & Lonai, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-12-01
- Volume
- 113
- Issue
- 4
- Pages
- 1419-1434
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2411135442
- Cited by
- 393
- References
- 1
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
