The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
Open accessAbstract
The Drosophila wing is formed by two cell populations, the anterior and posterior compartments, which are distin- guished by the activity of the selector gene engrailed (en) in posterior cells. Here, we show that en governs growth and patterning in both compartments by controlling the expression of the secreted proteins hedgehog (hh) and decapentaplegic (dpp) as well as the response of cells to these signaling molecules. First, we demonstrate that en activity programs wing cells to express hh whereas the absence of en activity programs them to respond to hh by expressing dpp. As a consequence, posterior cells secrete hh and induce a stripe of neighboring anterior cells across the compartment boundary to secrete dpp. Second, we demonstrate that dpp can exert a long-range organizing influence on surrounding wing tissue, specifying anterior or posterior pattern depending on the compartmental provenance, and hence the state of en activity, of the responding cells. Thus, dpp secreted by anterior cells along the compartment boundary has the capacity to organize the development of both compartments. Finally, we report evidence suggesting that dpp may exert its organizing influence by acting as a gradient morphogen in contrast to hh which appears to act principally as a short range inducer of dpp.
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Citations
Cites
Analysis of genetic mosaics in developing and adult Drosophila tissues
Xu, T., & Rubin, G. M. (1993) · Development · doi:10.1242/dev.117.4.1223 · Cited by 2,041
Expression of engrailed proteins in arthropods, annelids, and chordates
Patel, N. H., Martin-Blanco, E., Coleman, K. G., Poole, S. J., Ellis, M. C., Kornberg, T. B., & Goodman, C. S. (1989) · Cell · doi:10.1016/0092-8674(89)90947-1 · Cited by 1,014
Organizing activity of wingless protein in Drosophila
Struhl, G., & Basler, K. (1993) · Cell · doi:10.1016/0092-8674(93)90072-x · Cited by 843
Self-citationCompartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
Basler, K., & Struhl, G. (1994) · Nature · doi:10.1038/368208a0 · Cited by 833
Self-citationIsolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product
Evan, G. I., Lewis, G. K., Ramsay, G., & Bishop, J. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.12.3610-3616.1985 · Cited by 794
Developmental Compartmentalisation of the Wing Disk of Drosophila
GARCIA-BELLIDO, A., RIPOLL, P., & MORATA, G. (1973) · Nature New Biology · doi:10.1038/newbio245251a0 · Cited by 783
Padgett, R. W., St. Johnston, R. D., & Gelbart, W. M. (1987) · Nature · doi:10.1038/325081a0 · Cited by 751
The engrailed locus of drosophila: Structural analysis of an embryonic transcript
Poole, S. J., Kauvar, L. M., Drees, B., & Kornberg, T. (1985) · Cell · doi:10.1016/0092-8674(85)90306-x · Cited by 721
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
Tabata, T., & Kornberg, T. B. (1994) · Cell · doi:10.1016/0092-8674(94)90175-9 · Cited by 615
Positional signalling and specification of digits in chick limb morphogenesis
Tickle, C., Summerbell, D., & Wolpert, L. (1975) · Nature · doi:10.1038/254199a0 · Cited by 582
Cited by
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735
Self-citationWang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
Direct and Long-Range Action of a DPP Morphogen Gradient
Nellen, D., Burke, R., Struhl, G., & Basler, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81114-9 · Cited by 892
Self-citation1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H., & Cohen, S. M. (1996) · Nature · doi:10.1038/381387a0 · Cited by 623
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
Kim, J., Johnson, K., Chen, H. J., Carroll, S., & Laughon, A. (1997) · Nature · doi:10.1038/40906 · Cited by 527
Daughters against dpp modulates dpp organizing activity in Drosophila wing development
Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T. B., Christian, J. L., & Tabata, T. (1997) · Nature · doi:10.1038/39362 · Cited by 429
Hedgehog signaling is required for pituitary gland development
Treier, M., O’Connell, S., Gleiberman, A., Price, J., Szeto, D. P., Burgess, R., Chuang, P.-T., McMahon, A. P., & Rosenfeld, M. G. (2001) · Development · doi:10.1242/dev.128.3.377 · Cited by 299
Burke, R., & Basler, K. (1996) · Development · doi:10.1242/dev.122.7.2261 · Cited by 265
Self-citationZecca, M., & Struhl, G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000386 · Cited by 148
Self-citationPromoter specificity mediates the independent regulation of neighboring genes.
Merli, C., Bergstrom, D. E., Cygan, J. A., & Blackman, R. K. (1996) · Genes & Development · doi:10.1101/gad.10.10.1260 · Cited by 115
Metadata
- Authors
- Zecca, M., Basler, K., & Struhl, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-08-01
- Volume
- 121
- Issue
- 8
- Pages
- 2265-2278
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1871724379
- Cited by
- 494
- References
- 59
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- green
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