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Cited by 494

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

Open access
Zecca, Myriam, Basler, Konrad, Struhl, Gary·1995·Development
DOI 10.1242/dev.121.8.2265
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Abstract

The Drosophila wing is formed by two cell populations, the anterior and posterior compartments, which are distin- guished by the activity of the selector gene engrailed (en) in posterior cells. Here, we show that en governs growth and patterning in both compartments by controlling the expression of the secreted proteins hedgehog (hh) and decapentaplegic (dpp) as well as the response of cells to these signaling molecules. First, we demonstrate that en activity programs wing cells to express hh whereas the absence of en activity programs them to respond to hh by expressing dpp. As a consequence, posterior cells secrete hh and induce a stripe of neighboring anterior cells across the compartment boundary to secrete dpp. Second, we demonstrate that dpp can exert a long-range organizing influence on surrounding wing tissue, specifying anterior or posterior pattern depending on the compartmental provenance, and hence the state of en activity, of the responding cells. Thus, dpp secreted by anterior cells along the compartment boundary has the capacity to organize the development of both compartments. Finally, we report evidence suggesting that dpp may exert its organizing influence by acting as a gradient morphogen in contrast to hh which appears to act principally as a short range inducer of dpp.

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Metadata

Authors
Zecca, M., Basler, K., & Struhl, G.
Venue
Development
Publisher
The Company of Biologists
Published
1995-08-01
Volume
121
Issue
8
Pages
2265-2278
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.121.8.2265
OpenAlex
W1871724379
Cited by
494
References
59
FWCI
14.45
Type
journal article
Language
en
Open access
green

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