The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of a lineage of multipotent hematopoietic progenitors
Abstract
All multipotent hematopoietic progenitors in C57BL-Thy-1.1 bone marrow are divided among three subpopulations of Thy-1.1loSca-1+Lin−/loc-kit+cells:long-term reconstituting Mac-1−CD4−c-kit+ cells and transiently reconstituting Mac-1loCD4− or Mac-1loCD4lo cells. This study shows that the same populations, with similar functional activities, exist in mice whose hematopoietic systems were reconstituted by hematopoietic stem cells after lethal irradiation. We demonstrate that these populations form a lineage of multipotent progenitors from long-term self-renewing stem cells to the most mature multipotent progenitor population. In reconstituted mice, Mac-1−CD4−c-kit+ cells gave rise to Mac-1loCD4− cells, which gave rise to Mac-1loCD4lo cells. Mac-1−CD4−c-kit+ cells had long-term self-renewal potential, with each cell being capable of giving rise to more than 104 functionally similar Mac-1−CD4−c-kit+ cells. At least half of Mac-1loCD4− cells had transient self-renewal potential, detected in the spleen 7 days after reconstitution. Mac-1loCD4lo cells did not have detectable self-renewal potential. The identification of a lineage of multipotent progenitors provides an important tool for identifying genes that regulate self-renewal and lineage commitment.
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Cites
Wu, L., Li, C. L., & Shortman, K. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.903 · Cited by 400
Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential
Morrison, S. J., Prowse, K. R., Ho, P., & Weissman, I. L. (1996) · Immunity · doi:10.1016/s1074-7613(00)80316-7 · Cited by 394
Self-citation
Cited by
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Self-citationTumour stem cells and drug resistance
Dean, M., Fojo, T., & Bates, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1590 · Cited by 3,668
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Self-citationPurified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
Self-citationIdentification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
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Metadata
- Authors
- Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E., & Weissman, I. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-05-15
- Volume
- 124
- Issue
- 10
- Pages
- 1929-1939
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2169846226
- Cited by
- 483
- References
- 2
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E., & Weissman, I. L. (1997). Identification of a lineage of multipotent hematopoietic progenitors. Development. https://doi.org/10.1242/dev.124.10.1929
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