The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
MAP kinase in situ activation atlas during Drosophila embryogenesis
Abstract
Receptor tyrosine kinases (RTKs) and the signaling cascades that they trigger play central roles in diverse developmental processes. We describe the capacity to follow the active state of these signaling pathways in situ. This is achieved by monitoring, with a specific monoclonal antibody, the distribution of the active, dual phosphorylated form of MAP kinase (ERK). A dynamic pattern is observed during embryonic and larval phases of Drosophila development, which can be attributed, to a large extent, to the known RTKs. This specific detection has enabled us to determine the time of receptor activation, visualize gradients and boundaries of activation, and postulate the distribution of active ligands. Since the antibody was raised against the phosphorylated form of a conserved ERK peptide containing the TEY motif, this approach is applicable to a wide spectrum of multicellular organisms.
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Cites
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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
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An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control
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Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila
Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G., & Bellen, H. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00611-6 · Cited by 401
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
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Substrate-dependent control of MAPK phosphorylation in vivo
Kim, Y., Paroush, Z., Nairz, K., Hafen, E., Jiménez, G., & Shvartsman, S. Y. (2011) · Molecular Systems Biology · doi:10.1038/msb.2010.121 · Cited by 80
Kadam, S., McMahon, A., Tzou, P., & Stathopoulos, A. (2009) · Development · doi:10.1242/dev.027904 · Cited by 83
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations
Oishi, K., Gaengel, K., Krishnamoorthy, S., Kamiya, K., Kim, I.-K., Ying, H., Weber, U., Perkins, L. A., Tartaglia, M., Mlodzik, M., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi471 · Cited by 81
Whole-genome analysis of Drosophila gastrulation
Stathopoulos, A., & Levine, M. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.004 · Cited by 71
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Metadata
- Authors
- Gabay, L., Seger, R., & Shilo, B.-Z.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-09-15
- Volume
- 124
- Issue
- 18
- Pages
- 3535-3541
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2148649613
- Cited by
- 304
- References
- 39
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
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