The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fibroblast Growth Factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
Abstract
During mouse lung morphogenesis, the distal mesenchyme regulates the growth and branching of adjacent endoderm. We report here that fibroblast growth factor 10 (Fgf10) is expressed dynamically in the mesenchyme adjacent to the distal buds from the earliest stages of lung development. The temporal and spatial pattern of gene expression suggests that Fgf10 plays a role in directional outgrowth and possibly induction of epithelial buds, and that positive and negative regulators of Fgf10 are produced by the endoderm. In transgenic lungs overexpressing Shh in the endoderm, Fgf10 transcription is reduced, suggesting that high levels of SHH downregulate Fgf10. Addition of FGF10 to embryonic day 11.5 lung tissue (endoderm plus mesenchyme) in Matrigel or collagen gel culture elicits a cyst-like expansion of the endoderm after 24 hours. In Matrigel, but not collagen, this is followed by extensive budding after 48-60 hours. This response involves an increase in the rate of endodermal cell proliferation. The activity of FGF1, FGF7 and FGF10 was also tested directly on isolated endoderm in Matrigel culture. Under these conditions, FGF1 elicits immediate endodermal budding, while FGF7 and FGF10 initially induce expansion of the endoderm. However, within 24 hours, samples treated with FGF10 give rise to multiple buds, while FGF7-treated endoderm never progresses to bud formation, at all concentrations of factor tested. Although exogenous FGF1, FGF7 and FGF10 have overlapping activities in vitro, their in vivo expression patterns are quite distinct in relation to early branching events. We conclude that, during early lung development, localized sources of FGF10 in the mesoderm regulate endoderm proliferation and bud outgrowth.
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Cites
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Self-citationReceptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164
Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C., & Shima, D. T. (2002) · Genes & Development · doi:10.1101/gad.242002 · Cited by 914
In vitro generation of human pluripotent stem cell derived lung organoids
Dye, B. R., Hill, D. R., Ferguson, M. A., Tsai, Y.-H., Nagy, M. S., Dyal, R., Wells, J. M., Mayhew, C. N., Nattiv, R., Klein, O. D., et al. (2015) · eLife · doi:10.7554/elife.05098 · Cited by 819
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Lung development: orchestrating the generation and regeneration of a complex organ
Herriges, M., & Morrisey, E. E. (2014) · Development · doi:10.1242/dev.098186 · Cited by 613
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
Huang, S. X. L., Islam, M. N., O'Neill, J., Hu, Z., Yang, Y.-G., Chen, Y.-W., Mumau, M., Green, M. D., Vunjak-Novakovic, G., Bhattacharya, J., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2754 · Cited by 567
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M., & Hui, C.-C. (1998) · Nature Genetics · doi:10.1038/1711 · Cited by 560
Developmental Biology of Uterine Glands1
Gray, C. A., Bartol, F. F., Tarleton, B. J., Wiley, A. A., Johnson, G. A., Bazer, F. W., & Spencer, T. E. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1311 · Cited by 490
McCauley, K. B., Hawkins, F., Serra, M., Thomas, D. C., Jacob, A., & Kotton, D. N. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.03.001 · Cited by 432
Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
Lee, J.-H., Tammela, T., Hofree, M., Choi, J., Marjanovic, N. D., Han, S., Canner, D., Wu, K., Paschini, M., Bhang, D. H., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.028 · Cited by 361
El Agha, E., Moiseenko, A., Kheirollahi, V., De Langhe, S., Crnkovic, S., Kwapiszewska, G., Szibor, M., Kosanovic, D., Schwind, F., Schermuly, R. T., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.10.004 · Cited by 347
Self-citationEpithelial-Mesenchymal Interactions in the Developing Lung
Shannon, J. M., & Hyatt, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.135749 · Cited by 321
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M., & Deutsch, G. H. (2005) · Development · doi:10.1242/dev.01570 · Cited by 316
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
Kim, S. K., & Melton, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13036 · Cited by 265
Tissue remodelling through branching morphogenesis
Affolter, M., Zeller, R., & Caussinus, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2797 · Cited by 185
Habuchi, H., Nagai, N., Sugaya, N., Atsumi, F., Stevens, R. L., & Kimata, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607434200 · Cited by 139
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
Shaw, A. T., Meissner, A., Dowdle, J. A., Crowley, D., Magendantz, M., Ouyang, C., Parisi, T., Rajagopal, J., Blank, L. J., Bronson, R. T., et al. (2007) · Genes & Development · doi:10.1101/gad.1526207 · Cited by 131
The Structural Biology of the FGF19 Subfamily
Beenken, A., & Mohammadi, M. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-0887-1_1 · Cited by 93
Lüdtke, T. H., Rudat, C., Wojahn, I., Weiss, A.-C., Kleppa, M.-J., Kurz, J., Farin, H. F., Moon, A., Christoffels, V. M., & Kispert, A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.007 · Cited by 69
Retinoids in lung development and regeneration
Maden, M. (2004) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)61007-6 · Cited by 48
Metadata
- Authors
- Bellusci, S., Grindley, J., Emoto, H., Itoh, N., & Hogan, B. L. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-12-01
- Volume
- 124
- Issue
- 23
- Pages
- 4867-4878
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2110042849
- Cited by
- 1,003
- References
- 1
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
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