The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
Abstract
Spinal cord oligodendrocyte precursors arise in the ventral ventricular zone as a result of local signals. Ectopic oligodendrocyte precursors can be induced by sonic hedgehog (Shh) in explants of chick dorsal spinal cord over an extended developmental period. The role of Shh during normal oligodendrocyte development is, however, unclear. Here we demonstrate that Shh is localized to the ventral spinal cord immediately prior to, and during the appearance of oligodendrocyte precursors. Continued expression of Shh is required for the appearance of spinal cord oligodendrocyte precursors as neutralization of Shh signaling both in vivo and in vitro during a defined developmental period blocked their emergence. The inhibition of oligodendrocyte precursor emergence in the absence of Shh signaling was not the result of inhibiting precursor cell proliferation, and the neutralization of Shh signaling after the emergence of oligodendrocyte precursors had no effect on the appearance of additional cells or their subsequent differentiation. Similar concentrations of Shh induce motor neurons and oligodendrocytes in dorsal spinal cord explants. However, in explants from early embryos the motor neuron lineage is preferentially expanded while in explants from older embryos the oligodendrocyte lineage is preferentially expanded.
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Metadata
- Authors
- Orentas, D. M., Hayes, J. E., Dyer, K. L., & Miller, R. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-06-01
- Volume
- 126
- Issue
- 11
- Pages
- 2419-2429
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2167984281
- Cited by
- 265
- References
- 54
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
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