The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells
Abstract
The chemokine SDF-1α (CXC12) and its receptor CXCR4 have been shown to play a role in the development of normal cerebellar cytoarchitecture. We report here that SDF-1α both induces chemotactic responses in granule precursor cells and enhances granule cell proliferative responses to Sonic hedgehog. Chemotactic and proliferative responses to SDF-1α are greater in granule cells obtained from cerebella of animals in the first postnatal week, coinciding with the observed in vivo peak in cerebellar CXCR4 expression. SDF-1α activation of neuronal CXCR4 differs from activation of CXCR4 in leukocytes in that SDF-1α-induced calcium flux is activity dependent, requiring predepolarization with KCl or pretreatment with glutamate. However, as is the case in leukocytes, neuronal responses to SDF-1α are all abolished by pretreatment of granule cells with pertussis toxin, suggesting they occur through Gαi activation. In conclusion, SDF-1α plays a role in two important processes of granule cell maturation – proliferation and migration – assisting in the achievement of appropriate cell number and position in the cerebellar cortex.
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Cites
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Metadata
- Authors
- Klein, R. S., Rubin, J. B., Gibson, H. D., DeHaan, E. N., Alvarez-Hernandez, X., Segal, R. A., & Luster, A. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-06-01
- Volume
- 128
- Issue
- 11
- Pages
- 1971-1981
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1959046600
- Cited by
- 295
- References
- 3
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
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