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MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging

Kennerdell, Jason R., Liu, Nan, Bonini, Nancy M.·2018·Nature Communications
DOI 10.1038/s41467-018-06592-5PMC PMC6180074
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Abstract

Aging is a prominent risk factor for neurodegenerative disease. Defining gene expression mechanisms affecting healthy brain aging should lead to insight into genes that modulate susceptibility to disease. To define such mechanisms, we have pursued analysis of miR-34 mutants in Drosophila . The miR-34 mutant brain displays a gene expression profile of accelerated aging, and miR-34 upregulation is a potent suppressor of polyglutamine-induced neurodegeneration. We demonstrate that Pcl and Su(z)12 , two components of polycomb repressive complex 2, (PRC2), are targets of miR-34 , with implications for age-associated processes. Because PRC2 confers the repressive H3K27me3 mark, we hypothesize that miR-34 modulates PRC2 activity to relieve silencing of genes promoting healthful aging. Gene expression profiling of the brains of hypomorphic mutants in Enhancer of zeste ( E(z) ), the enzymatic methyltransferase component of PRC2, revealed a younger brain transcriptome profile and identified the small heat shock proteins as key genes reduced in expression with age.

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Metadata

Authors
Kennerdell, J. R., Liu, N., & Bonini, N. M.
ORCID
Bonini, Nancy M.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2018-10-10
Volume
9
Issue
1
ISSN
2041-1723
DOI
10.1038/s41467-018-06592-5
PMC
PMC6180074
Cited by
56
References
10
Language
en
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