Heart Valve Development, Maintenance, and Disease

Tao, Ge; Kotick, James D.; Lincoln, Joy

doi:10.1016/b978-0-12-387786-4.00006-3

Cited by 89Cardiac Valve Diseases and TreatmentsCongenital heart defects researchTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 167 of the 168 references it cites were found in a registry or an index.

Heart Valve Development, Maintenance, and Disease

Tao, Ge, Kotick, James D., Lincoln, Joy·2012·Current Topics in Developmental Biology

DOI 10.1016/b978-0-12-387786-4.00006-3

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Abstract

Heart valves are dynamic structures that open and close during the cardiac cycle to maintain unidirectional blood flow throughout life. Insufficient valve function, commonly due to congenital malformations leads to disruptions in hemodynamics and eventual heart failure. Mature valve leaflets are composed of a heterogeneous population of interstitial cells and stratified extracellular matrix, surrounded by a layer of endothelial cells. This defined connective tissue "architecture" provides the valve with all the necessary biomechanical properties required to efficiently function while withstanding constant cyclic shear stress. Valvular endothelial cells (VECs) play essential roles in establishing the valve structures during embryonic development and are important for maintaining lifelong valve integrity and function. In contrast to a continuous endothelium over the surface of healthy valve leaflets, VEC disruption is commonly observed in malfunctioning valves and is associated with pathological processes that promote valve sclerosis and calcification. Increasing our understanding of the roles of VECs in development and disease has lead to promising advances in the development of endothelial cell-based therapies for treating valve disease.

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VICs are specialized cardiac fibroblasts, generally quiescent under homeostatic conditions, and their activation is associated with valve disease including calcification and regurgitation.
“VICs, which are specialized cardiac fibroblasts, are generally quiescent under homoeostatic conditions, and their activation is intimately associated with valve disease states, including calcification and regurgitation2,3.”
From Cell diversity and plasticity during atrioventricular heart valve EMTs (2023) · cites this paper as [3]

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Authors: Tao, G., Kotick, J. D., & Lincoln, J.
Affiliations: University of Miami (US)
Abigail Wexner Research Institute (US)
ORCID: Tao, Ge
Lincoln, Joy
Venue: Current Topics in Developmental Biology
Publisher: Elsevier
Published: 2012
Volume: 100
Pages: 203-232
ISSN: 0070-2153 (ISSN-L)
DOI: 10.1016/b978-0-12-387786-4.00006-3
OpenAlex: W114778194
Cited by: 89
References: 168
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 13 · 2022: 13 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 11 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 1 · 2012: 1
FWCI: 28.14
Type: book chapter
Language: en
Open access: closed
Locations: Current topics in developmental biology/Current Topics in Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL091878)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: heart valves, valve leaflets, valvular endothelial cells, valve development, congenital heart disease, valve calcification, extracellular matrix, cyclic shear stress, heart failure
MeSH terms: Animals, Heart Valve Diseases, Heart Valves, Hemodynamics, Humans, Cell Lineage, Endothelial Cells

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Heart Valve Development, Maintenance, and Disease

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