The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity
Abstract
The daf-9 gene functions to integrate transforming growth factor-β and insulin-like signaling pathways to regulate Caenorhabditis elegans larval development. Mutations in daf-9 result in transient dauer-like larval arrest, abnormal reproductive development, molting defects and increased adult longevity. The phenotype is sterol-dependent, and dependent on the activity of DAF-12, a nuclear hormone receptor. Genetic tests show that daf-9 is upstream of daf-12 in the genetic pathways for larval development and adult longevity. daf-9 encodes a cytochrome P450 related to those involved in biosynthesis of steroid hormones in mammals. We propose that it specifies a step in the biosynthetic pathway for a DAF-12 ligand, which might be a steroid. The surprising cellular specificity of daf-9 expression (predominantly in two sensory neurons) supports a previously unrecognized role for these cells in neuroendocrine control of larval development, reproduction and life span.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Cited by
Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 615
Self-citationEndocrine regulation of ageing
Russell, S. J., & Kahn, C. R. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2234 · Cited by 356
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin‐like signals
Walker, G. A., & Lithgow, G. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00045.x · Cited by 273
Garrity, P. A., Goodman, M. B., Samuel, A. D., & Sengupta, P. (2010) · Genes & Development · doi:10.1101/gad.1953710 · Cited by 197
The role of estrogen deficiency in skin ageing and wound healing
Emmerson, E., & Hardman, M. J. (2012) · Biogerontology · doi:10.1007/s10522-011-9322-y · Cited by 118
The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation
Powolny, A. A., Singh, S. V., Melov, S., Hubbard, A., & Fisher, A. L. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.01.005 · Cited by 68
Metadata
- Authors
- Jia, K., Albert, P. S., & Riddle, D. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-01-01
- Volume
- 129
- Issue
- 1
- Pages
- 221-231
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2154265462
- Cited by
- 262
- References
- 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
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