The DOI matches its Crossref record.
Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
Abstract
We present here an analysis of cardiovascular and pharyngeal arch development in mouse embryos hypomorphic for Fgf8. Previously, we have described the generation of Fgf8 compound heterozygous (Fgf8neo/–) embryos. Although early analysis demonstrated that some of these embryos have abnormal left-right (LR) axis specification and cardiac looping reversals, the number and type of cardiac defects present at term suggested an additional role for Fgf8 in cardiovascular development. Most Fgf8neo/– mutant embryos survive to term with abnormal cardiovascular patterning, including outflow tract, arch artery and intracardiac defects. In addition, these mutants have hypoplastic pharyngeal arches, small or absent thymus and abnormal craniofacial development. Neural crest cells (NCCs) populate the pharyngeal arches and contribute to many structures of the face, neck and cardiovascular system, suggesting that Fgf8 may be required for NCC development. Fgf8 is expressed within the developing pharyngeal arch ectoderm and endoderm during NCC migration through the arches. Analysis of NCC development in Fgf8neo/– mutant embryos demonstrates that NCCs are specified and migrate, but undergo cell death in areas both adjacent and distal to where Fgf8 is normally expressed. This study defines the cardiovascular defects present in Fgf8 mutants and supports a role for Fgf8 in development of all the pharyngeal arches and in NCC survival.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Building the mammalian heart from two sources of myocardial cells
Buckingham, M., Meilhac, S., & Zaffran, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1710 · Cited by 1,204
Phenotypic impact of genomic structural variation: insights from and for human disease
Weischenfeldt, J., Symmons, O., Spitz, F., & Korbel, J. O. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3373 · Cited by 658
Minoux, M., & Rijli, F. M. (2010) · Development · doi:10.1242/dev.040048 · Cited by 507
Cranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Storm, E. E., Garel, S., Borello, U., Hebert, J. M., Martinez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R. (2006) · Development · doi:10.1242/dev.02324 · Cited by 366
Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development
Perantoni, A. O., Timofeeva, O., Naillat, F., Richman, C., Pajni-Underwood, S., Wilson, C., Vainio, S., Dove, L. F., & Lewandoski, M. (2005) · Development · doi:10.1242/dev.01945 · Cited by 347
The role of secondary heart field in cardiac development
Dyer, L. A., & Kirby, M. L. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.009 · Cited by 261
The neural crest in cardiac congenital anomalies
Keyte, A., & Hutson, M. R. (2012) · Differentiation · doi:10.1016/j.diff.2012.04.005 · Cited by 259
Embryonic Heart Progenitors and Cardiogenesis
Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013847 · Cited by 254
Newbern, J., Zhong, J., Wickramasinghe, R. S., Li, X., Wu, Y., Samuels, I., Cherosky, N., Karlo, J. C., O'Loughlin, B., Wikenheiser, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805239105 · Cited by 172
Mrass, P., Rendl, M., Mildner, M., Gruber, F., Lengauer, B., Ballaun, C., Eckhart, L., & Tschachler, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1129 · Cited by 112
Developmental nonlinearity drives phenotypic robustness
Green, R. M., Fish, J. L., Young, N. M., Smith, F. J., Roberts, B., Dolan, K., Choi, I., Leach, C. L., Gordon, P., Cheverud, J. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02037-7 · Cited by 106
FGF signaling is required for anterior but not posterior specification of the murine liver bud
Wang, J., Rhee, S., Palaria, A., & Tremblay, K. D. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24215 · Cited by 40
Elevated levels of Wnt signaling disrupt thymus morphogenesis and function
Swann, J. B., Happe, C., & Boehm, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-00842-0 · Cited by 38
Metadata
- Authors
- Abu-Issa, R., Smyth, G., Smoak, I., Yamamura, K.-I., & Meyers, E. N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-10-01
- Volume
- 129
- Issue
- 19
- Pages
- 4613-4625
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1955467086
- Cited by
- 448
- References
- 0
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
