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Plasticity in the lung: making and breaking cell identity

Tata, Purushothama Rao, Rajagopal, Jayaraj·2017·Development
DOI 10.1242/dev.143784
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Abstract

In contrast to a prior emphasis on the finality of cell fate decisions in developmental systems, cellular plasticity is now emerging as a general theme in the biology of multiple adult organ systems. In the lung, lineage tracing has been used to identify distinct epithelial stem and progenitor cell populations. These cells, together with their differentiated progeny, maintain a stable identity during steady state conditions, but can display remarkable lineage plasticity following injury. This Review summarizes our current understanding of the different cell lineages of the adult mammalian lung and their responses to injury. In the lung, which is constantly exposed to infection and aerosolized toxins, epithelial plasticity might be more of a rule than an exception, and it is likely that different injuries elicit different facultative responses.

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Metadata

Authors
Tata, P. R., & Rajagopal, J.
Affiliations
Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
ORCID
Venue
Development
Publisher
The Company of Biologists
Published
2017-03-01
Volume
144
Issue
5
Pages
755-766
ISSN
  • 1477-9129
  • 0950-1991
DOI
10.1242/dev.143784
Cited by
192
References
6
Language
en
Licence
www.biologists.com/user-licence-1-1 (vor, 184 d)
Funders
  • Howard Hughes Medical Institute
  • New York Stem Cell Foundation
  • Massachusetts General Hospital
  • Ludwig Institute for Cancer Research
  • Harvard Medical School
  • National Heart, Lung, and Blood Institute

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