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Localization and synthesis of alphafoetoprotein in post-implantation mouse embryos
Abstract
The localization and synthesis of alphafoetoprotein (AFP) during mouse embryogenesis were studied by immunoperoxidase and by immunoprecipitation after radioactive labelling, using an antiserum prepared against AFP. AFP is first detectable in embryos on the 7th day of gestation (7th day embryos). In 7th and 8th day embryos AFP is confined to visceral (proximal) endoderm cells around the embryonic region of the egg cylinder. Visceral extra-embryonic and parietal (distal) endoderm cells do not contain AFP. By the 9th day of gestation AFP is also present in the extra-embryonic ectoderm, mesoderm and embryonic ectoderm cells around the three cavities of the embryo. These tissues do not synthesize AFP when cultured in isolation, but can adsorb AFP when it is added to the medium. On the 12th day of gestation AFP synthesis is confined to the endoderm layer of the visceral yolk sac. It is concluded that the ability to synthesize AFP is a property which is restricted to the visceral endoderm during early post-implantation development. The presence of AFP in other tissues of the embryo appears to be due to adsorption.
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Cited by
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Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
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Anderson, R., Copeland, T. K., Schöler, H., Heasman, J., & Wylie, C. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00271-3 · Cited by 313
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
Hart, A. H., Hartley, L., Sourris, K., Stadler, E. S., Li, R., Stanley, E. G., Tam, P. P. L., Elefanty, A. G., & Robb, L. (2002) · Development · doi:10.1242/dev.129.15.3597 · Cited by 229
Houssaint, E. (1980) · Cell Differentiation · doi:10.1016/0045-6039(80)90026-3 · Cited by 209
BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm
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Artus, J., Douvaras, P., Piliszek, A., Isern, J., Baron, M. H., & Hadjantonakis, A.-K. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2011.10.015 · Cited by 83
Tg(Afp‐GFP) expression marks primitive and definitive endoderm lineages during mouse development
Kwon, G. S., Fraser, S. T., Eakin, G. S., Mangano, M., Isern, J., Sahr, K. E., Hadjantonakis, A., & Baron, M. H. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20843 · Cited by 80
Kwon, G. S., & Hadjantonakis, A. (2009) · genesis · doi:10.1002/dvg.20522 · Cited by 72
Harrison, S. M., Dunwoodie, S. L., Arkell, R. M., Lehrach, H., & Beddington, R. S. P. (1995) · Development · doi:10.1242/dev.121.8.2479 · Cited by 71
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Metadata
- Authors
- Dziadek, M., & Adamson, E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1978-02-01
- Volume
- 43
- Issue
- 1
- Pages
- 289-313
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2104244471
- Cited by
- 214
- References
- 0
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
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