Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors

Klopp, Ann H.; Zhang, Yan; Solley, Travis; Amaya-Manzanares, Felipe; Marini, Frank; Andreeff, Michael; Debeb, Bisrat; Woodward, Wendy; Schmandt, Rosemarie; Broaddus, Russell; Lu, Karen; Kolonin, Mikhail G.

doi:10.1158/1078-0432.ccr-11-1916

Cited by 179Mesenchymal stem cell researchCancer Cells and MetastasisAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors

Open access

Klopp, Ann H., Zhang, Yan, Solley, Travis, Amaya-Manzanares, Felipe, Marini, Frank, Andreeff, Michael, Debeb, Bisrat, Woodward, Wendy, Schmandt, Rosemarie, Broaddus, Russell, Lu, Karen, Kolonin, Mikhail G.·2012·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-11-1916PMC PMC3481843

Published version of a preprint

Open this paper in CoChat — free account Open PDF

Abstract

Purpose: Adipose tissue contains a population of tumor-tropic mesenchymal progenitors, termed adipose stromal cells (ASC), which engraft in neighboring tumors to form supportive tumor stroma. We hypothesized that intra-abdominal visceral adipose tissue may contain a uniquely tumor-promoting population of ASC to account for the relationship between excess visceral adipose tissue and mortality of intra-abdominal cancers. Experimental Design: To investigate this, we isolated and characterized ASC from intra-abdominal omental adipose tissue (O-ASC) and characterized their effects on endometrial cancer progression as compared with subcutaneous adipose-derived mesenchymal stromal cells (SC-ASC), bone marrow–derived mesenchymal stromal cells (BM-MSC), and lung fibroblasts. To model chronic recruitment of ASC by tumors, cells were injected metronomically into mice bearing Hec1a xenografts. Results: O-ASC expressed cell surface markers characteristic of BM-MSC and differentiated into mesenchymal lineages. Coculture with O-ASC increased endometrial cancer cell proliferation in vitro. Tumor tropism of O-ASC and SC-ASC for human Hec1a endometrial tumor xenografts was comparable, but O-ASC more potently promoted tumor growth. Compared with tumors in SC-ASC–injected mice, tumors in O-ASC–injected mice contained higher numbers of large tortuous desmin-positive blood vessels, which correlated with decreased central tumor necrosis and increased tumor cell proliferation. O-ASC exhibited enhanced motility as compared with SC-ASC in response to Hec1a-secreted factors. Conclusions: Visceral adipose tissue contains a population of multipotent MSCs that promote endometrial tumor growth more potently than MSCs from subcutaneous adipose tissue. We propose that O-ASCs recruited to tumors express specific factors that enhance tumor vascularization, promoting survival and proliferation of tumor cells. Clin Cancer Res; 18(3); 771–82. ©2011 AACR.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/1078-0432.ccr-11-1916

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Both bone marrow-derived and adipose-derived MSC show tumor tropism driven by various tumor-released chemotactic factors, including CCL25, CXCL1, EGF, HDGF, IL-8, PDGF, SDF1, TGFβ and VEGF.
“Both BM- and adipose-derived MSC display tumor tropism due to various tumor-released chemotactic factors including CCL25 [43], C-X-C motif chemokine-1 (CXCL1) [54], epidermal growth factor (EGF) [83, 84], hepatoma-derived growth factor (HDGF) [85], IL-8 [54], platelet-derived growth factor (PDGF) [84], stromal cell-derived factor-1 (SDF1, a.k.a. CXCL12) [86, 87], TGFβ [88], and VEGF [84].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [54]
Citation [54] is attached to CXCL1 and IL-8, not to the other listed factors. In Results, the paper reports that both are secreted by Hec1a tumor cells and that bone marrow-derived MSC and omental adipose stromal cells migrate in response to tumor-conditioned medium. It says CXCL1 and IL-8 may trigger chemotaxis, rather than establishing that either factor drives tumor tropism. (LLM, conf=0.85)
Experimental — accuracy not yet measured
All MSC populations share basic immunophenotypic and functional similarities, but high-resolution techniques reveal differences that are also reflected in variability of their secretome.
“Although all MSC populations share basic similarities immunophenotypically and functionally, differences can be demonstrated using high resolution techniques [52, 53] and are reflected in variability within their secretome [7, 54].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [54]
Subcutaneous adipose-derived MSC populations appear to secrete lower levels of VEGF than bone marrow-derived MSC or visceral adipose-derived stem/stromal cells.
“Subcutaneous adipose-derived MSC populations seem to secrete lower level of VEGF than BM-MSC [7, 54] or visceral ASC [54].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [54]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Self-citation
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., & Hedrick, M. H. (2001) · Tissue Engineering · doi:10.1089/107632701300062859 · Cited by 7,956
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1×
“Activation and proliferation of stromal cells recruited by tumors leads to their conversion into myofibroblasts/reactive stroma (12, 34, 35).”
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206
Putting tumours in context
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
Caplan, A. I. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21200 · Cited by 1,956
Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
Bianco, P., Robey, P. G., & Simmons, P. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.002 · Cited by 1,618
Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M., Graubard, B. I., Williamson, D. F., & Gail, M. H. (2007) · JAMA · doi:10.1001/jama.298.17.2028 · Cited by 1,542
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
Djouad, F., Plence, P., Bony, C., Tropel, P., Apparailly, F., Sany, J., Noël, D., & Jorgensen, C. (2003) · Blood · doi:10.1182/blood-2003-04-1193 · Cited by 1,166
HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,166
Self-citation
Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas
Nakamizo, A., Marini, F. C., Amano, T., Khan, A., Studeny, M., Gumin, J., Chen, J. J., Hentschel, S. J., Vecil, G. G., Dembinski, J. L., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1874 · Cited by 1,029
Self-citation
A Population of Multipotent CD34-Positive Adipose Stromal Cells Share Pericyte and Mesenchymal Surface Markers, Reside in a Periendothelial Location, and Stabilize Endothelial Networks
Traktuev, D. O., Merfeld‐Clauss, S., Li, J., Kolonin, M. G., Arap, W., Pasqualini, R., Johnstone, B. H., & March, K. L. (2007) · Circulation Research · doi:10.1161/circresaha.107.159475 · Cited by 843
Self-citation
Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents
Studeny, M., Marini, F. C., Dembinski, J. L., Zompetta, C., Cabreira-Hansen, M. D. G., Bekele, B. N., Champlin, R. E., & Andreeff, M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh299 · Cited by 841
Self-citation
Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
Spaeth, E. L., Dembinski, J. L., Sasser, A. K., Watson, K., Klopp, A., Hall, B., Andreeff, M., & Marini, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004992 · Cited by 807
Self-citation
Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type
Orimo, A., & Weinberg, R. A. (2006) · Cell Cycle · doi:10.4161/cc.5.15.3112 · Cited by 794
Overweight as an avoidable cause of cancer in Europe
Bergström, A., Pisani, P., Tenet, V., Wolk, A., & Adami, H. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(200002)9999:9999 · Cited by 785
Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging
Kidd, S. M., Spaeth, E. L., Dembinski, J. L., Dietrich, M. F., Watson, K., Klopp, A. H., Battula, V. L., Weil, M., Andreeff, M., & Marini, F. C. (2009) · Stem Cells · doi:10.1002/stem.187 · Cited by 680
Self-citation
Regulation of In Situ to Invasive Breast Carcinoma Transition
Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 513
Obesity and Cancer Risk: Recent Review and Evidence
Basen-Engquist, K., & Chang, M. (2011) · Current Oncology Reports · doi:10.1007/s11912-010-0139-7 · Cited by 439
White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models
Zhang, Y., Daquinag, A., Traktuev, D. O., Amaya-Manzanares, F., Simmons, P. J., March, K. L., Pasqualini, R., Arap, W., & Kolonin, M. G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3444 · Cited by 331
Self-citation
Tumor Irradiation Increases the Recruitment of Circulating Mesenchymal Stem Cells into the Tumor Microenvironment
Klopp, A. H., Spaeth, E. L., Dembinski, J. L., Woodward, W. A., Munshi, A., Meyn, R. E., Cox, J. D., Andreeff, M., & Marini, F. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1406 · Cited by 304
Self-citation
Depot-Specific Differences in Adipogenic Progenitor Abundance and Proliferative Response to High-Fat Diet
Joe, A. W., Yi, L., Even, Y., Vogl, A. W., & Rossi, F. M. V. (2009) · Stem Cells · doi:10.1002/stem.190 · Cited by 296
Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer
Kamat, A. A., Merritt, W. M., Coffey, D., Lin, Y. G., Patel, P. R., Broaddus, R. R., Nugent, E. K., Han, L. Y., Landen, C. N., Spannuth, W. A., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1017 · Cited by 194
Self-citation
Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines
Birnbaum, T., Roider, J., Schankin, C. J., Padovan, C. S., Schichor, C., Goldbrunner, R., & Straube, A. M. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9332-4 · Cited by 192
Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition
Friedenreich, C. M., Cust, A. E., Lahmann, P. H., Steindorf, K., Boutron‐Ruault, M., Clavel‐Chapelon, F., Mesrine, S., Linseisen, J., Rohrmann, S., Boeing, H., et al. (2007) · Cancer Causes & Control · doi:10.1007/s10552-006-0113-8 · Cited by 177
Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells
Klopp, A. H., Lacerda, L., Gupta, A., Debeb, B. G., Solley, T. N., Li, L., Spaeth, E. L., Xu, W., Zhang, X., Lewis, M. T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012180 · Cited by 174
Self-citation
Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles
Hall, B., Dembinski, J., Sasser, A., Studeny, M., Andreeff, M., & Marini, F. (2007) · International Journal of Hematology · doi:10.1532/ijh97.06230 · Cited by 171
Self-citation
Irradiation Enhances the Tumor Tropism and Therapeutic Potential of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Glioma Therapy
Kim, S. M., Oh, J. H., Park, S. A., Ryu, C. H., Lim, J. Y., Kim, D., Chang, J. W., Oh, W., & Jeun, S. (2010) · Stem Cells · doi:10.1002/stem.543 · Cited by 140
Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice
Galiè, M., Konstantinidou, G., Peroni, D., Scambi, I., Marchini, C., Lisi, V., Krampera, M., Magnani, P., Merigo, F., Montani, M., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210920 · Cited by 130
More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor Microenvironment
Baglole, C. J., Ray, D. M., Bernstein, S. H., Feldon, S. E., Smith, T. J., Sime, P. J., & Phipps, R. P. (2006) · Immunological Investigations · doi:10.1080/08820130600754960 · Cited by 118
Influence of BMI on Level of Circulating Progenitor Cells
Bellows, C. F., Zhang, Y., Simmons, P. J., Khalsa, A. S., & Kolonin, M. G. (2011) · Obesity · doi:10.1038/oby.2010.347 · Cited by 105
Self-citation
A Novel Regulatory Role for Stromal-derived Factor-1 Signaling in Bone Morphogenic Protein-2 Osteogenic Differentiation of Mesenchymal C2C12 Cells
Zhu, W., Boachie-Adjei, O., Rawlins, B. A., Frenkel, B., Boskey, A. L., Ivashkiv, L. B., & Blobel, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610232200 · Cited by 103
Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor
Halpern, J. L., Kilbarger, A. K., & Lynch, C. C. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.04.018 · Cited by 102
IFATS Collection: Combinatorial Peptides Identify α5β1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells
Nie, J., Chang, B. H.-J., Traktuev, D. O., Sun, J. D., March, K. L., Chan, L., Sage, E. H., Pasqualini, R., Arap, W., & Kolonin, M. G. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0212 · Cited by 82
Self-citation
Circulation of Progenitor Cells in Obese and Lean Colorectal Cancer Patients
Bellows, C. F., Zhang, Y., Chen, J., Frazier, M. L., & Kolonin, M. G. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0556 · Cited by 78
Self-citation
Myometrial Invasion and Lymph Node Metastasis in Endometrioid Carcinomas: Tumor-associated Macrophages, Microvessel Density, and HIF1A Have a Crucial Role
Espinosa, Í., Carnicer, M. J., Catasús, L., Canet, B., D′Angelo, E., Zannoni, G. F., & Prat, J. (2010) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181f32168 · Cited by 77
Vascular targeting of adipose tissue as an anti-obesity approach
Daquinag, A. C., Zhang, Y., & Kolonin, M. G. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.01.004 · Cited by 74
Self-citation
Rapid expansion of human adipose-derived stromal cells preserving multipotency
D, H. S. M., Shigeura, T., Matsumoto, D., Inoue, K., D, H. K. M., D, N. A. M., Murase, S., Sato, K., Gonda, K., Koshima, I., et al. (2007) · Cytotherapy · doi:10.1080/14653240701679873 · Cited by 73
Intra-abdominal Fat Predicts Survival in Pancreatic Cancer
Balentine, C. J., Enriquez, J., Fisher, W. P., Hodges, S. E., Bansal, V., Sansgiry, S., Petersen, N. J., & Berger, D. H. (2010) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-010-1297-5 · Cited by 71
Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Women's Health Study
Prizment, A. E., Flood, A. P., Anderson, K. E., & Folsom, A. R. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0522 · Cited by 65
Preadipocyte Number in Omental and Subcutaneous Adipose Tissue of Obese Individuals
Bakker, A. H. F., van Dielen, F. M. H., Greve, J. W. M., Adam, J. A., & Buurman, W. A. (2004) · Obesity Research · doi:10.1038/oby.2004.55 · Cited by 63
Engineered Mesenchymal Stem Cells for Cartilage Repair
Djouad, F., Mrugala, D., Noël, D., & Jørgensen, C. (2006) · Regenerative Medicine · doi:10.2217/17460751.1.4.529 · Cited by 57
Combinatorial stem cell mobilization
Kolonin, M. G., & Simmons, P. J. (2009) · Nature Biotechnology · doi:10.1038/nbt0309-252 · Cited by 40
Self-citation
Omentectomy for Gynecologic Cancer: How Much Sampling Is Adequate for Microscopic Examination?
Usubutün, A., Özşeker, H. S., Himmetoğlu, Ç., Balcı, S., & Ayhan, A. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-1578-ofgchm · Cited by 35

Flagged first, then by citations

Sorted by citations

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Baenke, F., Peck, B., Miess, H., & Schulze, A. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.011338 · Cited by 772
Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment
Onstad, M. A., Schmandt, R. E., & Lu, K. H. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.69.4638 · Cited by 667
Self-citation
The obese adipose tissue microenvironment in cancer development and progression
Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542
Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors
Lengyel, E. R., Makowski, L., DiGiovanni, J., & Kolonin, M. G. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.03.004 · Cited by 436
Self-citation
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Yang, L., Moss, T., Mangala, L. S., Marini, J., Zhao, H., Wahlig, S., Armaiz‐Pena, G., Jiang, D., Achreja, A., Win, J., et al. (2014) · Molecular Systems Biology · doi:10.1002/msb.20134892 · Cited by 326
Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications
Zhuang, W.-Z., Lin, Y.-H., Su, L., Wu, M.-S., Jeng, H.-Y., Chang, H., Huang, Y., & Ling, T. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00725-7 · Cited by 276
Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors
Zhang, T., Lee, W., Rui, Y., Cheng, T.-Y., Jiang, X., & Li, G. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt221 · Cited by 244
Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment
Zhang, Y., Daquinag, A. C., Amaya-Manzanares, F., Sirin, O., Tseng, C., & Kolonin, M. G. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0294 · Cited by 233
Self-citation
An Evolving story of the Metastatic Voyage of Ovarian Cancer Cells: Cellular and Molecular Orchestration of the Adipose-Rich Metastatic Microenvironment
Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Carrami, E. M., Hu, Z., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0637-x · Cited by 218
Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies
Lin, Y.-H., Chen, Y.-H., Chang, H.-Y., Au, H., Tzeng, C., & Huang, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082385 · Cited by 192
Mesenchymal stem cell secretome and regenerative therapy after cancer
Zimmerlin, L., Park, T. S., Zambidis, E. T., Donnenberg, V. S., & Donnenberg, A. D. (2013) · Biochimie · doi:10.1016/j.biochi.2013.05.010 · Cited by 168
“compared the behavior of BM-MSC, visceral and subcutaneous ASC [54] in both in vitro and in vivo studies of endometrial cancer.”
BackgroundResultInfluential
Adipose Tissue Engineering in Three-Dimensional Levitation Tissue Culture System Based on Magnetic Nanoparticles
Daquinag, A. C., Souza, G. R., & Kolonin, M. G. (2012) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2012.0198 · Cited by 169
Self-citation
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs
Zhao, Q., Gregory, C. A., Lee, R. H., Reger, R. L., Qin, L., Hai, B., Park, M. S., Yoon, N., Clough, B. H., McNeill, E. P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423008112 · Cited by 164
Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment
Gomez-Chou, S. B., Swidnicka-Siergiejko, A. K., Badi, N., Chavez-Tomar, M., Lesinski, G. B., Bekaii‐Saab, T., Farren, M. R., Mace, T. A., Schmidt, C. R., Liu, Y., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1986 · Cited by 162
CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment
Zhang, T., Tseng, C., Zhang, Y., Sirin, O., Corn, P. G., Li-Ning-Tapia, E. M., Troncoso, P., Davis, J. W., Pettaway, C. A., Ward, J. F., et al. (2016) · Nature Communications · doi:10.1038/ncomms11674 · Cited by 160
Self-citation
Omentum a powerful biological source in regenerative surgery
Nicola, V. D. (2019) · Regenerative Therapy · doi:10.1016/j.reth.2019.07.008 · Cited by 154
Ovarian cancer stem cells: Working towards the root of stemness
Foster, R., Buckanovich, R. J., & Rueda, B. R. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.10.023 · Cited by 148
The Role of Chronic Inflammation in Obesity-Associated Cancers
Ramos‐Niño, M. E. (2013) · ISRN Oncology · doi:10.1155/2013/697521 · Cited by 134
Adipose-Derived Stems Cells and Their Role in Human Cancer Development, Growth, Progression, and Metastasis: A Systematic Review
Freese, K. E., Kokai, L. E., Edwards, R. P., Philips, B. J., Sheikh, M. A., Kelley, J. L., Comerci, J. T., Marra, K. G., Rubin, J. P., & Linkov, F. Y. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2744 · Cited by 128
Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort
Stolzenberg‐Solomon, R. Z., Schairer, C., Moore, S., Hollenbeck, A. R., & Silverman, D. T. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058123 · Cited by 119
Human Omental-Derived Adipose Stem Cells Increase Ovarian Cancer Proliferation, Migration, and Chemoresistance
Nowicka, A., Marini, F. C., Solley, T. N., Elizondo, P. B., Zhang, Y., Sharp, H. J., Broaddus, R. R., Kolonin, M. G., Mok, S. C., Thompson, M. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081859 · Cited by 119
Self-citation
Proinflammatory CXCL12–CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice
Saha, A., Ahn, S., Blando, J. M., Su, F., Kolonin, M. G., & DiGiovanni, J. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0284 · Cited by 105
Self-citation
Abdominal obesity and gastroesophageal cancer risk: Systematic review and meta-analysis of prospective studies
Du, X., Hidayat, K., & Shi, B.-M. (2017) · Bioscience Reports · doi:10.1042/bsr20160474 · Cited by 98
Peri‐prostatic adipose tissue: the metabolic microenvironment of prostate cancer
Nassar, Z. D., Aref, A. T., Miladinovic, D., Mah, C. Y., Raj, G. V., Hoy, A. J., & Butler, L. M. (2018) · British Journal of Urology · doi:10.1111/bju.14173 · Cited by 105
Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells
Salimian Rizi, B., Caneba, C., Nowicka, A., Nabiyar, A. W., Liu, X., Chen, K., Klopp, A., & Nagrath, D. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1337 · Cited by 98
Self-citation
Mesenchymal stem cells: A living carrier for active tumor-targeted delivery
Zhang, T., Lin, R., Wu, H., Jiang, X., & Gao, J. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114300 · Cited by 90
Stem cells from adipose tissue and breast cancer: hype, risks and hope
Bertolini, F., Petit, J.-Y., & Kolonin, M. G. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.657 · Cited by 90
Self-citation
Adipose tissue-derived progenitor cells and cancer
Zhang, Y. (2010) · World Journal of Stem Cells · doi:10.4252/wjsc.v2.i5.103 · Cited by 87
Self-citation
Obesity and prostate cancer — microenvironmental roles of adipose tissue
Saha, A., Kolonin, M. G., & DiGiovanni, J. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00764-9 · Cited by 88
Self-citation
Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer
Chu, Y., Tang, H., Guo, Y. P., Guo, J., Huang, B., Fang, F., Cai, J., & Wang, Z. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.07.020 · Cited by 85
Metformin limits the adipocyte tumor-promoting effect on ovarian cancer
Tebbe, C., Chhina, J., Dar, S. A., Sarigiannis, K. A., Giri, S., Munkarah, A. R., & Rattan, R. (2014) · Oncotarget · doi:10.18632/oncotarget.2012 · Cited by 83
Adipose tissue cells, lipotransfer and cancer: A challenge for scientists, oncologists and surgeons
Bertolini, F., Lohsiriwat, V., Petit, J., & Kolonin, M. G. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.04.004 · Cited by 83
Self-citation
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Di Franco, S., Bianca, P., Sardina, D. S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L. R., Lo Iacono, M., Pillitteri, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25333-9 · Cited by 80
Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer
Muñoz-Galván, S., & Carnero, A. (2020) · Cells · doi:10.3390/cells9061402 · Cited by 81
Systematic review: The oncological safety of adipose fat transfer after breast cancer surgery
Waked, K., Colle, J., Doornaert, M. A. J., Cocquyt, V., & Blondeel, P. N. (2016) · The Breast · doi:10.1016/j.breast.2016.11.001 · Cited by 74
Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts
Pacioni, S., D’Alessandris, Q. G., Giannetti, S., Morgante, L., Pascalis, I. D., Coccè, V., Bonomi, A., Pascucci, L., Alessandri, G., Pessina, A., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0185-z · Cited by 73
The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival
Matsuo, K., Gray, M. J., Yang, D., Srivastava, S., Tripathi, P. B., Sonoda, L. A., Yoo, E.-J., Dubeau, L., Lee, A. S., & Lin, Y. G. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.11.024 · Cited by 71
Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas
Kerrigan, B. C. P., Shimizu, Y., Andreeff, M., & Lang, F. F. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.02.002 · Cited by 72
Self-citation
Adipose-Derived Stem Cells in Cancer Progression: New Perspectives and Opportunities
Scioli, M. G., Storti, G., D’Amico, F., Gentile, P., Kim, B., Cervelli, V., & Orlandi, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133296 · Cited by 75
GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade
Yung, M. M. H., Tang, H. W., Cai, P. C. H., Leung, T. H.-Y., Ngu, S., Chan, K. K. L., Xu, D., Yang, H., Ngan, H., & Chan, D. W. (2018) · Theranostics · doi:10.7150/thno.22536 · Cited by 70
Circulating Leptin and Risk of Pancreatic Cancer: A Pooled Analysis From 3 Cohorts
Stolzenberg‐Solomon, R. Z., Newton, C. C., Silverman, D. T., Pollak, M., Nogueira, L., Weinstein, S. J., Albanes, D., Männistö, S., & Jacobs, E. J. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv041 · Cited by 65
A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer
Yasin, H. K., Taylor, A. H., & Ayakannu, T. (2021) · Cancers · doi:10.3390/cancers13092149 · Cited by 65
A randomized trial of diet and physical activity in women treated for stage II–IV ovarian cancer: Rationale and design of the Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES): An NRG Oncology/Gynecologic Oncology Group (GOG-225) Study
Thomson, C. A., Crane, T. E., Miller, A., Garcia, D. O., Basen-Engquist, K. M., & Alberts, D. S. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.07.005 · Cited by 59
Methylation-mediated repression of MiR-424/503 cluster promotes proliferation and migration of ovarian cancer cells through targeting the hub gene KIF23
Li, T., Li, Y., Gan, Y., Tian, R., Wu, Q., Shu, G., & Yin, G. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1624112 · Cited by 57
Apoptotic pathways in adipose tissue
Herold, C., Rennekampff, H. O., & Engeli, S. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0848-0 · Cited by 57
The Role of Adipose Tissue and Obesity in Causing Treatment Resistance of Acute Lymphoblastic Leukemia
Sheng, X., & Mittelman, S. D. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00053 · Cited by 62
The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance
Motohara, T., Yoshida, G. J., & Katabuchi, H. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.038 · Cited by 54
Ovarian Tumor Attachment, Invasion, and Vascularization Reflect Unique Microenvironments in the Peritoneum: Insights from Xenograft and Mathematical Models
Steinkamp, M. P., Winner, K. K., Davies, S., Muller, C. Y., Zhang, Y., Hoffman, R. M., Shirinifard, A., Moses, M. E., Jiang, Y., & Wilson, B. S. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00097 · Cited by 54
Self-citation
Recent insights into the pathophysiology of omental metastases
Koppe, M. J., Nagtegaal, I. D., de Wilt, J. H. W., & Ceelen, W. P. (2014) · Journal of Surgical Oncology · doi:10.1002/jso.23681 · Cited by 53
Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway
Kim, B., Kim, H. S., Kim, S., Haegeman, G., Tsang, B. K., Dhanasekaran, D. N., & Song, Y. S. (2016) · Cancer Research and Treatment · doi:10.4143/crt.2016.175 · Cited by 53
Obesity‐Associated Dysregulation of Calpastatin and MMP‐15 in Adipose‐Derived Stromal Cells Results in their Enhanced Invasion
Strong, A. L., Semon, J. A., Strong, T. A., Santoke, T. T., Zhang, S., McFerrin, H. E., Gimble, J. M., & Bunnell, B. A. (2012) · Stem Cells · doi:10.1002/stem.1229 · Cited by 50
Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
on behalf of the Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity, Lee, K. R., Seo, M. H., Han, K., Jung, J.-H., & Hwang, I. C. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0214-7 · Cited by 52
Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth
Daquinag, A. C., Tseng, C., Zhang, Y., Amaya‐Manzanares, F., Florez, F., Dadbin, A., Zhang, T., & Kolonin, M. G. (2015) · Molecular Therapy · doi:10.1038/mt.2015.155 · Cited by 46
Self-citation
Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers
Zhang, Y., Nowicka, A., Solley, T. N., Wei, C., Parikh, A. M., Court, L. E., Burks, J. K., Andreeff, M., Woodward, W. A., Dadbin, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136361 · Cited by 47
Self-citation
Brown adipose tissue and cancer progression
Chu, K. F., Bos, S. A., Gill, C. M., Torriani, M., & Bredella, M. A. (2019) · Skeletal Radiology · doi:10.1007/s00256-019-03322-w · Cited by 43
Metastasis-associated fibroblasts in peritoneal surface malignancies
Ramos, C., Gerakopoulos, V., & Oehler, R. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02717-4 · Cited by 42
Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer
Yeh, W., Tsai, C., & Chen, D. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0630-2 · Cited by 42
Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity
Bos, S. A., Gill, C. M., Martínez-Salazar, E. L., Torriani, M., & Bredella, M. A. (2018) · Skeletal Radiology · doi:10.1007/s00256-018-3046-x · Cited by 43
GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis
Zhong, Z., Gu, H., Peng, J., Wang, W., Johnstone, B. H., March, K. L., Farlow, M. R., & Du, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.9208 · Cited by 41
Treatment of obesity as a potential complementary approach to cancer therapy
Sirin, O., & Kolonin, M. G. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.05.008 · Cited by 41
Self-citation
Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
Eckel‐Mahan, K. L., Ribas‐Latre, A., & Kolonin, M. G. (2020) · Cells · doi:10.3390/cells9040863 · Cited by 41
Self-citation
Morphological and Functional Changes in the Peritumoral Adipose Tissue of Colorectal Cancer Patients
Zoico, E., Rizzatti, V., Darra, E., Budui, S. L., Franceschetti, G., Vinante, F., Pedrazzani, C., Guglielmi, A., Manzoni, G. D., Mazzali, G., et al. (2017) · Obesity · doi:10.1002/oby.22008 · Cited by 39
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
Stamatopoulos, A., Stamatopoulos, T., Gamie, Z., Kenanidis, E., Ribeiro, R. D. C., Rankin, K. S., Gerrand, C., Dalgarno, K., & Tsiridis, E. (2019) · Journal of Bone Oncology · doi:10.1016/j.jbo.2019.100231 · Cited by 37
“Interleukin-8 (IL-8) Hec1a endometrial carcinoma [199] O-ASC Recruitment of SCs and possible tumour progression”
Background
Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc1638N/+ Female Mice
Huffman, D. M., Augenlicht, L. H., Zhang, X., Lofrese, J. J., Atzmon, G., Chamberland, J. P., & Mantzoros, C. S. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0414 · Cited by 37
Non-glycanated Decorin Is a Drug Target on Human Adipose Stromal Cells
Daquinag, A. C., Dadbin, A., Snyder, B., Wang, X., Şahin, A. A., Ueno, N. T., & Kolonin, M. G. (2017) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2017.05.003 · Cited by 37
Self-citation
Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma
Ribeiro, R. J. T., Monteiro, C., Silvestre, R., Castela, Â., Coutinho, H., Fraga, A. M., Príncipe, P., Lobato, C., Costa, C., Cordeiro‐da‐Silva, A., et al. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012131 · Cited by 37
Novel fluorinated polycationic delivery of anti-VEGF siRNA for tumor therapy
Yuan, Z., Guo, X., Wei, M., Xu, Y., Fang, Z., Feng, Y., & Yuan, W. (2020) · NPG Asia Materials · doi:10.1038/s41427-020-0216-9 · Cited by 36
Adipose-derived stem cells induced EMT-like changes in H358 lung cancer cells.
Park, Y. M., Yoo, S. H., & Kim, S.-H. (2013) · PubMed · Cited by 36
Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity
Tseng, C., & Kolonin, M. G. (2015) · Stem Cells · doi:10.1002/stem.2192 · Cited by 35
Self-citation
Hypoxia-induced secretion of IL-10 from adipose-derived mesenchymal stem cell promotes growth and cancer stem cell properties of Burkitt lymphoma
Xu, L., Wang, X., Wang, J., Liu, D., Wang, Y., Huang, Z., & Tan, H. (2015) · Tumor Biology · doi:10.1007/s13277-015-4664-8 · Cited by 35
The Differences in the Characteristics of Insulin-producing Cells Using Human Adipose-tissue Derived Mesenchymal Stem Cells from Subcutaneous and Visceral Tissues
Wada, Y., Ikemoto, T., Morine, Y., Imura, S., Saito, Y., Yamada, S., & Shimada, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-49701-0 · Cited by 32
An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics
Shaik, B., Zafar, T., Balasubramanian, K., & Gupta, S. P. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620999201111155426 · Cited by 35
Comparative characterization of mesenchymal stromal cells from multiple abdominal adipose tissues and enrichment of angiogenic ability via CD146 molecule
Lee, N. E., Kim, S. J., Yang, S.-J., Joo, S.-Y., Park, H., Lee, K. W., Yang, H.-M., & Park, J. B. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.11.002 · Cited by 34
Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer
Amor, S., de la Cruz, M. D. C. I., Ferrero, E., García-Villar, O., Barrios, V., Fernández, N., Monge, L., Garcı́a-Villalón, Á. L., & Granado, M. (2015) · International Journal of Colorectal Disease · doi:10.1007/s00384-015-2420-6 · Cited by 31
Cyr61 from adipose‐derived stem cells promotes colorectal cancer metastasis and vasculogenic mimicry formation via integrin α V β 5
Liang, Z., Liu, H., Zhang, Y., Xiong, L., Zeng, Z., He, X., Wang, F., Wu, X., & Lan, P. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12998 · Cited by 33
Self-citation
Human omental adipose-derived mesenchymal stem cell-conditioned medium alters the proteomic profile of epithelial ovarian cancer cell lines in vitro
Zhang, Y., Dong, W., Wang, J., Cai, J., & Wang, Z. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s129502 · Cited by 33
Self-citation
Adipose-derived stem cells promote glycolysis and peritoneal metastasis via TGF-β1/SMAD3/ANGPTL4 axis in colorectal cancer
Zhu, C., Teng, L., Lai, Y., Yao, X., Fang, Y., Wang, Z., Lin, S., Zhang, H., Li, Q., Li, Y., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05215-1 · Cited by 32
Self-citation
Prognostic value of anthropometric measures extracted from whole-body CT using deep learning in patients with non-small-cell lung cancer
Blanc‐Durand, P., Campedel, L., Mulé, S., Jégou, S., Luciani, A., Pigneur, F., & Itti, E. (2020) · European Radiology · doi:10.1007/s00330-019-06630-w · Cited by 32
Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt/β-catenin signaling pathway
Xu, Y., Hu, J., Lv, Q., Shi, C., Qiu, M., Xie, L., Liu, W., Yang, B., Shan, W., Cheng, Y., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03387-4 · Cited by 31
Pathogenic Role of Adipose Tissue-Derived Mesenchymal Stem Cells in Obesity and Obesity-Related Inflammatory Diseases
Pestel, J., Blangero, F., & Eljaafari, A. (2023) · Cells · doi:10.3390/cells12030348 · Cited by 31
Generation of a Dual-Functioning Antitumor Immune Response in the Peritoneal Cavity
Sedlacek, A. L., Gerber, S. A., Randall, T. D., van Rooijen, N., Frelinger, J. G., & Lord, E. M. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.06.030 · Cited by 31
Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis
Lu, H., Poirier, C., Cook, T. G., Traktuev, D. O., Merfeld‐Clauss, S., Lease, B. R., Petrache, I., March, K. L., & Bogatcheva, N. V. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0422-3 · Cited by 29
Role of mesenchymal cells in the natural history of ovarian cancer: a review
Touboul, C., Vidal, F., Pasquier, J., Lis, R., & Rafii, A. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0271-5 · Cited by 29
In vitro differentiation of rat mesenchymal stem cells to hepatocyte lineage.
Sarvandi, S. S., Joghataei, M. T., Parivar, K., Khosravi, M., Sarveazad, A., & Sanadgol, N. (2015) · Europe PMC (PubMed Central) · Cited by 28
Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment
Teoh, S. L., & Das, S. (2016) · Tumor Biology · doi:10.1007/s13277-016-5357-7 · Cited by 29
“Ins” and “Outs” of mesenchymal stem cell osteogenesis in regenerative medicine
Yamaguchi, D. T. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i2.94 · Cited by 29
Human-derived normal mesenchymal stem/stromal cells in anticancer therapies
Zhang, C., Yang, S., Wen, Q., Zhong, J. F., Chen, X., Stucky, A., Press, M. F., & Zhang, X. (2016) · Journal of Cancer · doi:10.7150/jca.16792 · Cited by 27
Adipose-derived stem cells in ovarian cancer progression, metastasis, and chemoresistance
Zhang, W., Torres-Rojas, C., Yue, J., & Zhu, B. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211023846 · Cited by 25
c-Kit-Positive Adipose Tissue-Derived Mesenchymal Stem Cells Promote the Growth and Angiogenesis of Breast Cancer
Li, W., Xu, H., & Qian, C. (2017) · BioMed Research International · doi:10.1155/2017/7407168 · Cited by 25
The therapeutic potential of bone marrow‐derived mesenchymal stromal cells on hepatocellular carcinoma
Bayo, J., Marrodán, M., Aquino, J. B., Silva, M., García, M. G., & Mazzolini, G. D. (2013) · Liver International · doi:10.1111/liv.12338 · Cited by 24
Association of obesity and circulating adipose stromal cells among breast cancer survivors
Ghosh, S., Hughes, D. C., Parma, D. L., Ramírez, A. G., & Li, R. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3146-1 · Cited by 24
Regenerative potential of human adipose-derived stromal cells of various origins
Jung, S., Kleineidam, B., & Kleinheinz, J. (2015) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2015.10.002 · Cited by 22
Silymarin amplifies apoptosis in ectopic endometrial tissue in rats with endometriosis; implication on growth factor GDNF, ERK1/2 and Bcl-6b expression
Nahari, E., & Razi, M. (2018) · Acta Histochemica · doi:10.1016/j.acthis.2018.08.003 · Cited by 23
Spontaneous formation of tumorigenic hybrids between human omental adipose-derived stromal cells and endometrial cancer cells increased motility and heterogeneity of cancer cells
Li, M., Li, X., Zhao, L., Zhou, J., Cheng, Y., Xu, B., Wang, J., & Wei, L. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1568743 · Cited by 21
Omental Preadipocytes Stimulate Matrix Remodeling and IGF Signaling to Support Ovarian Cancer Metastasis
Waters, J. A., Robinson, M., Lujano-Olazaba, O., Lucht, C., Gilbert, S. F., & House, C. D. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2613 · Cited by 20
Adipose-Derived Stem Cells Facilitate Ovarian Tumor Growth and Metastasis by Promoting Epithelial to Mesenchymal Transition Through Activating the TGF-β Pathway
Liu, X., Zhao, G., Huo, X., Wang, Y., Tigyi, G., Zhu, B., Yue, J., & Zhang, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756011 · Cited by 20
Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on hepatic ischemia-reperfusion and hepatectomy injury in swine
Zhang, Q., Piao, C., Xu, J., Jiao, Z., Ge, Y., Liu, X., Ma, Y., & Wang, H. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109453 · Cited by 20
Perirenal Adiposity is Associated with Lower Progression-Free Survival from Ovarian Cancer
Zhang, Y., Coletta, A. M., Allen, P. K., Parikh, A. M., Cox-Mattin, M., Meyer, L. A., Sun, C. C., Basen-Engquist, K. M., Lu, K. H., & Klopp, A. H. (2018) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000001165 · Cited by 20
Self-citation
Macrophages in ovarian cancer and their interactions with monoclonal antibody therapies
Osborn, G., Stavraka, C., Adams, R., Sayasneh, A., Ghosh, S., Montes, A., Lacy, K. E., Kristeleit, R. S., Spicer, J. F., Josephs, D. H., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab020 · Cited by 19
Obesity-Related Cross-Talk between Prostate Cancer and Peripheral Fat: Potential Role of Exosomes
Feng, S., Lou, K., Luo, C., Zou, J., Zou, X., & Zhang, G. (2022) · Cancers · doi:10.3390/cancers14205077 · Cited by 18

Abstract 3407: Human omental-derived adipose stem cells support growth of intra-peritoneal ovarian cancer xenografts and increase in-vitro proliferation and migration of ovarian cancer cells
Sharp, H. J., Marini, F. C., Solley, T. N., Broaddus, R. R., Kolonin, M. G., Mok, S., Schmandt, R. E., Woodward, W. A., Andreef, M., Lu, K. H., et al. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-3407 · Cited by 1
Self-citation
Human Omental-derived Adipose Stem Cells Decrease Ovarian Tumor Radiosensitivity and Promote Ovarian Tumor Proliferation, Migration, and Growth
Sharp, H. J., Marini, F. C., Solley, T. N., Broaddus, R. R., Kolonin, M. G., Mok, S. C., Schmandt, R. E., Woodward, W. A., Lu, K. H., & Klopp, A. H. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.06.174
Self-citation
Abstract A67: Obesity promotes growth of ovarian cancer through adipose stem cells
Zhang, Y., Solley, T. N., Nowicka, A., & Klopp, A. H. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ovca13-a67
Self-citation
RESEARCH ARTICLE Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers
Zhang, Y., Nowicka, R., Solley, T. N., Parikh, A., Court, L., Burks, J. K., Andreeff, M., Woodward, W. A., Dadbin, A., Kolonin, M. G., et al. (2016)
Self-citation
The role of adipose-derived stem cells in endometrial cancer proliferation
Linkov, F. Y., Kokai, L. E., Edwards, R. P., Sheikh, M. A., Freese, K. E., Marra, K. G., & Rubin, J. P. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.936682 · Cited by 18

Authors: Klopp, A. H., Zhang, Y., Solley, T., Amaya-Manzanares, F., Marini, F., Andreeff, M., Debeb, B., Woodward, W., Schmandt, R., Broaddus, R., Lu, K., & Kolonin, M. G.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Authors' Affiliations: Departments of 1Radiation Oncology, 2Leukemia, 3Gynecologic Oncology, and 4Pathology, The University of Texas MD Anderson Cancer Center; and 5The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Corresponding author: Kolonin, Mikhail G.
ORCID: Klopp, Ann H.
Marini, Frank
Andreeff, Michael
Debeb, Bisrat
Woodward, Wendy
Schmandt, Rosemarie
Broaddus, Russell
Kolonin, Mikhail G.
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2012-01-31
Volume: 18
Issue: 3
Pages: 771-782
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-11-1916
PMC: PMC3481843
OpenAlex: W2126961122
Cited by: 178
References: 49
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 19 · 2022: 6 · 2021: 13 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 17 · 2016: 12 · 2015: 21 · 2014: 16 · 2013: 22 · 2012: 8
FWCI: 7.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (KG080782)
National Cancer Institute (P50CA098258, P50CA140388, R01CA109451, RC1CA146381, P50CA083639, P30CA016672)
National Institute of Neurological Disorders and Stroke (R01NS069964, R01NS06994)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: omental adipose tissue, adipose-derived stromal cells, endometrial cancer, tumor vascularization, tumor stroma, visceral adipose tissue, mesenchymal stem cells, tumor cell proliferation, tumor necrosis, cell motility, tumor microenvironment
MeSH terms: Adipose Tissue, Animals, Cell Differentiation, Female, Flow Cytometry, Humans, Neovascularization, Pathologic, Omentum, Transplantation, Heterologous, Endometrial Neoplasms, Stromal Cells, Subcutaneous Fat, Mice, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks