Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism
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The effects of the roots of Polygonum cuspidatum SIEB. et ZUCC. ("Kojo-kon" or "Itadori-kon" in Japanese) and its stilbene components (resveratrol and piceid) on lipid metabolism in rats and mice (higher animals) were investigated. Resveratrol and piceid inhibited the deposition of triglyceride and cholesterol in the liver of rats fed corn oil-cholesterol-cholic acid mixture. Piceid reduced the serum triglyceride and low density lipoprotein-cholesterol (LDL-ch) levels, and atherogenic index [total cholesterolhigh density lipoprotein-cholesterol (HDL-ch)/HDL-ch] in the oil mixture-fed rats. It was found that intraperitoneal or oral administration of resveratrol or piceid reduced triglyceride synthesis from 14C-palmitate in the liver of mice. In contrast, these stilbene components did not affect hormone-induced lipolysis in fat cells from rat eqididymal adipose tissue.
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Resveratrol reduces hepatic lipid synthesis in rats.
“Consistent with data in rats, where resveratrol has been shown to reduce hepatic lipid synthesis (Ahn et al., 2008; Arichi et al., 1982), we observed reduced IHL content.”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Arichi et al., 1982
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Research works printed but not linked: 4
- [1]M. Kubo, Y. Kimura, H. Shin, H. Haneda, T. Tani, and K. Namba, Shoyakugaku Zasshi, 35(1), 58 (1981). a) K. Tsukida and M. Yonemichi, Yakugaku Zasshi, 74, 379 (1954); b) T. Murakami, K. Ikeda, and M. Takido, Chem. Pharm. Bull., 16, 2299 (1968); c) S. Nonomura, H. Kanagawa, and A. Makimoto, Yakugaku Zasshi, 83, 983 (1963).
- [3]V.P. Dole, J. Clin. Invest., 35, 150 (1965).
- [4]B. Börgstrom, Acta Physiol. Scand., 25, 111 (1952).
- [6]Y. Kimura, M. Kubo, T. Tani, S. Arichi, H. Ohminami, and H. Okuda, Chem. Pharm. Bull., 29, 2308 (1981) j L. Marx, Science, 205, 677 (1979).
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- Authors
- ARICHI, H., KIMURA, Y., OKUDA, H., BABA, K., KOZAWA, M., & ARICHI, S.
- Affiliations
- Ehime University (JP)
- ORCID
- KIMURA, YOSHIYUKI
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1982
- Volume
- 30
- Issue
- 5
- Pages
- 1766-1770
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2074933469
- Cited by
- 255
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 17 · 2012: 12
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- Polygonum cuspidatum, stilbene glycosides, resveratrol, piceid, lipid metabolism, cholesterol deposition, serum triglycerides, LDL cholesterol, atherogenic index, hepatic triglyceride synthesis, palmitate, adipose tissue
- MeSH terms
- Animals, Male, Plants, Medicinal, Rats, Inbred Strains, Stilbenes, Lipid Metabolism, Rats
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