Cited by 138Ginger and Zingiberaceae researchGastrointestinal motility and disordersGinseng Biological Effects and Applications

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Gastrointestinal motility enhancing effect of ginger and its active constituents.

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YAMAHARA, Johji, HUANG, Qirong, LI, Yuhao, XU, Lin, FUJIMURA, Hajime·1990·Chemical and Pharmaceutical Bulletin

DOI 10.1248/cpb.38.430

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Abstract

The effect of ginger root (Zingiberis Rhizoma) on gastrointestinal motility was examined based on its ability to enhance charcoal meal transport in mice. Oral administrations of the acetone extract of ginger (which contains volatile oils and bitter substances) at 75 mg/kg, [6]-shogaol at 2.5 mg/kg, or a [6]-, [8]- or [10]-gingerol at 5 mg/kg enhanced the transport of a charcoal meal. The effects of these substances were similar to or slightly weaker than those of metoclopramide and donperidone.

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[2]J. Yamahara, Q. R. Huang, M. Iwamoto, G. Kobayashi, H. Matsuda and H. Fujimura, Phytotherapy Research, 3, 70 (1989).
[1]M. Aburada, J. Traditional Sino-Japanese Medicine, 8, 45 (1987).
[3]J. Yamahara, Q. R. Huang, Y. Naitoh, T. Kitani and H. Fujimura, J. Ethnopharmacology, 27(3), 353 (1989).
[5]F. D. King and G. J. Sanger, "Annual Reports in Medicinal Chemistry," Vol. 23, Academic Press, Inc., California, 1988, p. 201.
[4]M. S. Hadiey, F. D. King, B. McRitchie, D. H. Turner and E. A. Watts, J. Med. Chem., 28, 1843 (1985).
[6]Y. Kasahara, E. Saito and H. Hikino, Shoyakugaku Zasshi, 37, 73 (1983).

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Authors: YAMAHARA, J., HUANG, Q., LI, Y., XU, L., & FUJIMURA, H.
Affiliations: Kyoto Pharmaceutical University (JP)
ORCID: HUANG, Qirong
LI, Yuhao
XU, Lin
Venue: Chemical and Pharmaceutical Bulletin
Publisher: Pharmaceutical Society of Japan
Published: 1990
Volume: 38
Issue: 2
Pages: 430-431
ISSN: 0009-2363 (ISSN-L)
1347-5223
DOI: 10.1248/cpb.38.430
OpenAlex: W2037992963
Cited by: 138
References: 0
Citations by year: 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 3
FWCI: 0.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Chemical and Pharmaceutical Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginseng Biological Effects and Applications
Keywords: ginger, Zingiberis Rhizoma, gastrointestinal motility, 6-shogaol, gingerol, essential oils, bitter compounds, metoclopramide, prokinetic agents
MeSH terms: Animals, Catechols, Condiments, Fatty Alcohols, Gastrointestinal Motility, Male, Plant Extracts, Mice

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Gastrointestinal motility enhancing effect of ginger and its active constituents.

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