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Cited by 122Natural Antidiabetic Agents StudiesMangiferin and Mango ExtractsDiabetes Treatment and Management

Antihyperglycemic effect of mangiferin in streptozotocin induced diabetic rats

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Sellamuthu, Periyar Selvam, Muniappan, Balu Periamallipatti, Perumal, Sathiya Moorthi, Kandasamy, Murugesan·2009·Journal of Health Science
DOI 10.1248/jhs.55.206
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Abstract

The study was undertaken to evaluate the antihyperglycemic potential of mangiferin purified from methanolic root extract of Salacia chinensis (S. chinensis) in control and streptozotocin (STZ)-induced diabetic rats. The mangiferin was administered orally at a dose of 40 mg/kg weight per day (30 days) to STZ-induced diabetic rats. The mangiferin treated diabetic rats significantly decreased the level of blood glucose, glycosylated hemoglobin as well as increased level of insulin and hemoglobin. The activities of hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glycogen synthase, and glycogen content level were increased to near normal in mangiferin treated diabetic rats. The activities of lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-diphosphatase and glycogen phosphorylase were significantly decreased in liver tissue of diabetic treated rats. These findings demonstrated that mangiferin possess antidiabetic activity against STZ-induced diabetic rats. The antidiabetic effect of mangiferin was compared with standard antidiabetic drug glibenclamide.

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  • A nonclinical study reported favorable tolerability of MGF at pharmacologically relevant exposures, with adverse findings emerging at substantially higher doses.

    “A nonclinical study has previously reported favorable tolerability at pharmacologically relevant exposures, with adverse findings emerging at substantially higher doses (180).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [180]

    The Materials and Methods section identifies 40 mg/kg/day as the dose used in diabetic rats and 25–500 mg/kg/day as the toxicity-test range. Contrary to the claim that adverse findings emerged at higher doses, Acute Toxicity Studies reports no toxic reactions at any tested dose over 30 days. (LLM, conf=0.88)

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  • Oral treatment with 40 mg/kg mangiferin for 30 days notably improved red and white blood cell levels in STZ-induced diabetic mice.

    “Furthermore, the levels of red and white blood cells were notably improved (25,26).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [26]

    Materials and Methods describes oral treatment with 40 mg/kg mangiferin for 30 days in STZ-induced diabetic rats, not mice. The Glucose Tolerance Test section reports increased hemoglobin after treatment, but neither it nor the searched passages reports improved red or white blood cell counts; hemoglobin is not a cell count. (LLM, conf=0.88)

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  • Mangiferin treatment is beneficial in streptozotocin-induced diabetic mice.

    “It was recently reported that mangiferin treatment was beneficial in streptozotocin (STZ)-induced diabetic mice.”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [26]

    The Materials and Methods passage describes mangiferin treatment in STZ-induced diabetic rats, not mice. The Discussion reports improved blood glucose and insulin measures in those rats, supporting a beneficial effect but not the claimed species. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Oral treatment with 40 mg/kg mangiferin for 30 days significantly reduced blood glucose, glycosylated hemoglobin, AST, ALT and ALP in STZ-induced diabetic mice compared with diabetic control mice.

    “Compared with diabetic control mice, the levels of blood glucose, glycosylated hemoglobin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were significantly reduced in mangiferin-treated diabetic mice.”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [26]

    Materials and Methods describes oral mangiferin at 40 mg/kg daily for 30 days in STZ-induced diabetic rats, not mice. The Glucose Tolerance Test section reports reduced blood glucose and glycosylated hemoglobin in treated rats relative to diabetic controls. Our copy does not report reductions in AST, ALT, or ALP; its reported liver-enzyme outcomes concern carbohydrate metabolism. (LLM, conf=0.90)

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Cites

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Research works printed but not linked: 3

  1. Pullaiah, T. and Chandrasekhar Naidu, K. (2000) Antidiabetic plants in India and herbal based antidi- abetic research, Regency Publications, New Delhi, pp. 3-9.
  2. Leloir, L. F. and Goldenberg, S. H. (1979) In Glyco- gen synthase from rat liver in "Methods of enzymol- ogy" (Colowick, S. P. and Kalpan, N. O., eds.), Aca- demic Press, New York, pp. 145-148.
  3. Saxena, A., Bhatnagar, M. and Garg, N. K. (1984) Enzyme charges in rat tissues during hyperglycemia. Arogya Journal of Health Sciences, 10, 33-37.

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Authors
Sellamuthu, P. S., Muniappan, B. P., Perumal, S. M., & Kandasamy, M.
Affiliations
  • University of Madras (IN)
  • Dr. M.G.R. Educational and Research Institute (IN)
ORCID
Sellamuthu, Periyar Selvam
Venue
Journal of Health Science
Publisher
Pharmaceutical Society of Japan
Published
2009
Volume
55
Issue
2
Pages
206-214
ISSN
  • 0013-273X (ISSN-L)
  • 1344-9702
  • 1347-5207
DOI
10.1248/jhs.55.206
OpenAlex
W2119896760
Cited by
122
References
46
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 12 · 2012: 7
FWCI
4.60
Type
journal article
Language
en
Open access
Locations
Eisei kagaku (publishedVersion)
Funders
Department of Science and Technology, Ministry of Science and Technology, India
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
mangiferin, hypoglycemic effect, antidiabetic activity, Salacia chinensis, streptozotocin-induced diabetes, blood glucose, HbA1c, insulin, glycogen metabolism, liver glycogen, glibenclamide, methanolic root extract

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