Mangiferin from Salacia chinensis Prevents Oxidative Stress and Protects Pancreatic β -Cells in Streptozotocin-Induced Diabetic Rats
Open accessAbstract
Oxidative stress in diabetic tissues is a consequence of free radical accumulation with concurrently impaired natural antioxidants status and results in oxidative tissue damage. The present study investigated the protective effects of mangiferin against pancreatic β-cell damage and on the antioxidant defense systems in streptozotocin (STZ)-induced diabetic rats. Diabetes was experimentally induced by a single intraperitoneal injection of STZ. Oxidative stress biomarkers such as tissue malondialdehyde, hydroperoxides, reduced glutathione (GSH) content, and nonenzymatic antioxidants were measured. Biochemical observations were further substantiated with histological examination and ultrastructural studies in the pancreas of diabetic, glibenclamide and mangiferin-treated diabetic rats (dosage of 40 mg/kg body weight daily for 30 days). Oral administration of mangiferin and glibenclamide to diabetic rats significantly decreased the level of blood glucose and increased levels of insulin. Additionally, mangiferin treatment significantly modulated the pancreatic nonenzymatic antioxidants status (vitamin C, vitamin E, ceruloplasmin, and reduced GSH content) and other oxidative stress biomarkers. The histoarchitecture of diabetic rats showed degenerated pancreas with lower β-cell counts, but mangiferin treatment effectively regenerated insulin secreting islet cells. The electron microscopic study revealed damaged nuclear envelope and mitochondria and fewer secretory granules in pancreas of diabetic rats; however, mangiferin treatment nearly normalized pancreatic architecture. The present findings suggest that mangiferin treatment exerts a therapeutic protective nature in diabetes by decreasing oxidative stress and protecting against pancreatic β-cell damage, which may be attributable to its antioxidative properties.
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Mangiferin in diabetic rats increased liver levels of superoxide dismutase, catalase, and glutathione peroxidase.
“Also, another study involving the use of mangiferin in diabetic rats identified increased liver levels of the following antioxidant enzymes: superoxide dismutase, catalase, and glutathione peroxidase [66].”
From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [66]
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- Authors
- Sellamuthu, P. S., Arulselvan, P., Muniappan, B. P., Fakurazi, S., & Kandasamy, M.
- Affiliations
- SRM Institute of Science and Technology (IN)
- Universiti Putra Malaysia (MY)
- University of Madras (IN)
- Corresponding author
- Sellamuthu, Periyar Selvam
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2013-08
- Volume
- 16
- Issue
- 8
- Pages
- 719-727
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2030616827
- Cited by
- 70
- References
- 51
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 2
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- green
- psasir.upm.edu.my
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- mangiferin, Salacia chinensis, oxidative stress, pancreatic beta-cell damage, streptozotocin-induced diabetes, antioxidant defense, malondialdehyde, reduced glutathione, vitamin C, vitamin E, ceruloplasmin, glibenclamide, insulin secretion, pancreatic islet regeneration, mitochondrial damage, diabetes mellitus
- MeSH terms
- Animals, Antioxidants, Blood Glucose, Diabetes Mellitus, Experimental, Humans, Insulin, Islets of Langerhans, Male, Malondialdehyde, Plant Extracts, Rats, Wistar, Oxidative Stress, Protective Agents, Xanthones, Salacia, Insulin-Secreting Cells, Rats
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