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Cited by 82Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesCardiovascular and exercise physiology

Substrate oxidation and GH responses to exercise are independent of menstrual phase and status

KANALEY, J. A., BOILEAU, R. A., BAHR, J. A., MISNER, J. E., NELSON, R. A.·1992·Medicine & Science in Sports & Exercise
DOI 10.1249/00005768-199208000-00008
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Abstract

The purpose of this study was to determine the extent to which growth hormone (GH) and energy substrate utilization are influenced by basal sex steroid levels during prolonged submaximal exercise across menstrual phase and status. Also the 17 beta-estradiol (E2) and progesterone responses during prolonged exercise were compared according to menstrual phase and menstrual status. Six amenorrheic (AMc) athletes and seven eumenorrheic (EUc) athletes ran at 60% VO2max for 90 min and serial blood samples were taken at rest, every 10 min throughout exercise, and 5 and 15 min post-exercise. The EUc athletes were tested in the early follicular phase (EF) (days 3-5), the late follicular phase (LF) (days 14-16) and the mid-luteal phase (ML) (days 22-25). The incremental GH response to exercise, measured by area under the curve, was consistent with previous reposts and was not altered according to menstrual phase or status (EF-37.5 +/- 11.5, LF-61.9 +/- 11.5, ML-48.1 +/- 12.8 micrograms.1-1.90 min-1). Furthermore, carbohydrate and fat utilization during exercise were not influenced by basal sex steroid levels associated with menstrual phase or status. The incremental E2 response to exercise in AMc athletes was significantly smaller than seen in EUc athletes (AMc-208.1 +/- 44.0, EF-383.0 +/- 116.4, LF-204.7 +/- 84.1, ML-45.1 +/- 18.4 pmol.1(-1).90 min-1), although the pattern of release is similar between groups. In conclusion, GH levels and substrate utilization are independent of both menstrual phase and status; hence, menstrual phase has no negative ramifications on metabolism during exercise. Amenorrhea does not result in metabolic consequences during prolonged exercise by influencing substrate utilization.

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Authors
KANALEY, J. A., BOILEAU, R. A., BAHR, J. A., MISNER, J. E., & NELSON, R. A.
Affiliations
University of Illinois Urbana-Champaign (US)
ORCID
KANALEY, J. A.
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-08
Volume
24
Issue
8
Pages
873???880
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/00005768-199208000-00008
OpenAlex
W2090892804
Cited by
82
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
growth hormone response, physical activity, menstrual cycle phases, amenorrhea, eumenorrhea, estradiol, progesterone, sex steroids, energy substrate utilization, carbohydrate utilization, fat utilization, submaximal exercise, female athletes, exercise metabolism
MeSH terms
Adolescent, Adult, Amenorrhea, Blood Glucose, Estrogens, Fats, Female, Humans, Lactates, Menstrual Cycle, Oxygen Consumption, Progesterone, Growth Hormone, Exercise, Carbohydrate Metabolism

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