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Cited by 144Adipokines, Inflammation, and Metabolic DiseasesPhysical Activity and HealthLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein

RAWSON, ERIC S., FREEDSON, PATTY S., OSGANIAN, STAVROULA K., MATTHEWS, CHARLES E., REED, GEORGE, OCKENE, IRA S.·2003·Medicine & Science in Sports & Exercise
DOI 10.1249/01.mss.0000074565.79230.ab
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Abstract

UNLABELLED: Elevated high-sensitivity c-reactive protein (hs-CRP) is associated with increased risk of future first and recurrent coronary events and has been associated with both high body mass index (BMI) and low physical activity in cross sectional studies. PURPOSE: To longitudinally examine the effects of BMI and both current and previous-year physical activity on hs-CRP in healthy men and women (N = 109). METHODS: BMI and hs-CRP were measured five times (baseline and quarterly) over 1 yr. Current physical activity was assessed 12-15 times during the study via 24-h recall. Previous-year physical activity was assessed using the Baecke questionnaire at baseline. RESULTS: Mean BMI and hs-CRP were unchanged over the course of the study, but current physical activity increased on visit 3. Average hs-CRP was not related to average current physical activity or to natural changes in current physical activity across the five visits. Additionally, current physical activity on any given visit was not associated with hs-CRP on the following visit. When current physical activity, BMI, age, gender, and smoking were included in the statistical model, only BMI was significantly related to hs-CRP (P < 0.001). Average hs-CRP was significantly correlated with average BMI (r = 0.50; P < 0.001) but was not related to previous-year (Baecke) physical activity levels (r = 0.02; P = 0.89). When subjects were grouped by BMI (<25 kg.m-2, 25-29.9 kg x m-2, >30 kg x m-2) hs-CRP was significantly greater in obese (3.2 +/- 1.9 mg.L-1) and overweight (2.1 +/- 1.7 mg x L-1) than normal weight (1.1 +/- 1.0 mg.L-1) subjects (ANOVA P < 0.05). Current physical activity was similar between the three BMI groups at all times, and was unrelated to hs-CRP in all groups, throughout the study period. CONCLUSION: These data indicate that BMI, but not previous-year or current physical activity, predicts hs-CRP.

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Crossref · 10.1249/01.mss.0000074565.79230.ab

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Metadata

Authors
RAWSON, E. S., FREEDSON, P. S., OSGANIAN, S. K., MATTHEWS, C. E., REED, G., & OCKENE, I. S.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • Vanderbilt University Medical Center (US)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-07
Volume
35
Issue
7
Pages
1160-1166
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/01.mss.0000074565.79230.ab
OpenAlex
W2085846919
Cited by
144
References
30
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 4 · 2013: 7 · 2012: 13
FWCI
8.22
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship@UMassChan (submittedVersion)
  • ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders
  • National Institutes of Health (5r01hl052745-04)
  • National Heart, Lung, and Blood Institute (R01 HL 52745)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
body mass index, physical activity, C-reactive protein, inflammation, obesity, overweight, cardiovascular risk factors
MeSH terms
Adult, C-Reactive Protein, Female, Heart Diseases, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Obesity, Physical Fitness, Risk Factors, Biomarkers, Exercise, Body Mass Index

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