Cited by 102Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyAdipose Tissue and Metabolism

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Exercise and GLUT4

Flores-Opazo, Marcelo, McGee, Sean L., Hargreaves, Mark·2020·Exercise and Sport Sciences Reviews

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Abstract

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.

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Authors: Flores-Opazo, M., McGee, S. L., & Hargreaves, M.
Affiliations: Laboratory of Exercise and Physical Activity Sciences, Department of Physiotherapy, University Finis Terrae, Santiago, Chile
Deakin University (AU)
The University of Melbourne (AU)
Corresponding author: Hargreaves, Mark
ORCID: McGee, Sean L.
Hargreaves, Mark
Venue: Exercise and Sport Sciences Reviews
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2020-07
Volume: 48
Issue: 3
Pages: 110-118
ISSN: 0091-6331 (ISSN-L)
1538-3008
DOI: 10.1249/jes.0000000000000224
OpenAlex: W3036769478
Cited by: 102
References: 158
Citations by year: 2026: 20 · 2025: 17 · 2024: 17 · 2023: 15 · 2022: 22 · 2021: 10 · 2020: 1
FWCI: 1.15
Type: journal article
Language: en
Open access: closed
Locations: Exercise and Sport Sciences Reviews (publishedVersion)
PubMed (publishedVersion)
Own your potential (DEAKIN) (submittedVersion)
Figshare (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: GLUT4, glucose transporters, physical activity, skeletal muscle glucose uptake, insulin sensitivity, GLUT4 translocation, sarcolemma, T-tubules, GLUT4 expression, muscle contraction
MeSH terms: Animals, Glucose, Humans, Insulin Resistance, Muscle Contraction, Sarcolemma, Transcription, Genetic, Exercise, Muscle, Skeletal, Protein Transport, Glucose Transporter Type 4

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