Cited by 102Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyAdipose Tissue and Metabolism

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Exercise and GLUT4

Flores-Opazo, Marcelo, McGee, Sean L., Hargreaves, Mark·2020·Exercise and Sport Sciences Reviews

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Abstract

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.

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“In addition to GEF and MEF2 regulation of adipose tissue GLUT4 expression (150), the liver X receptor α appears to have a role in GLUT4 expression (151), although to our knowledge, exercise effects on these factors have not been studied.”
Background
Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress
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Increased Skeletal Muscle GLUT4 Expression in Obese Mice After Voluntary Wheel Running Exercise Is Posttranscriptional
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Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats
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Authors: Flores-Opazo, M., McGee, S. L., & Hargreaves, M.
Affiliations: Laboratory of Exercise and Physical Activity Sciences, Department of Physiotherapy, University Finis Terrae, Santiago, Chile
Deakin University (AU)
The University of Melbourne (AU)
Corresponding author: Hargreaves, Mark
ORCID: McGee, Sean L.
Hargreaves, Mark
Venue: Exercise and Sport Sciences Reviews
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2020-07
Volume: 48
Issue: 3
Pages: 110-118
ISSN: 0091-6331 (ISSN-L)
1538-3008
DOI: 10.1249/jes.0000000000000224
OpenAlex: W3036769478
Cited by: 102
References: 158
Citations by year: 2026: 20 · 2025: 17 · 2024: 17 · 2023: 15 · 2022: 22 · 2021: 10 · 2020: 1
FWCI: 1.15
Type: journal article
Language: en
Open access: closed
Locations: Exercise and Sport Sciences Reviews (publishedVersion)
PubMed (publishedVersion)
Own your potential (DEAKIN) (submittedVersion)
Figshare (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: GLUT4, glucose transporters, physical activity, skeletal muscle glucose uptake, insulin sensitivity, GLUT4 translocation, sarcolemma, T-tubules, GLUT4 expression, muscle contraction
MeSH terms: Animals, Glucose, Humans, Insulin Resistance, Muscle Contraction, Sarcolemma, Transcription, Genetic, Exercise, Muscle, Skeletal, Protein Transport, Glucose Transporter Type 4

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Exercise and GLUT4

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