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Cited by 75Exercise and Physiological ResponsesSleep and Work-Related FatigueMuscle metabolism and nutrition

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Effects of Sleep Deprivation on Acute Skeletal Muscle Recovery after Exercise

DÁTTILO, MURILO, ANTUNES, HANNA KAREN MOREIRA, GALBES, NADINE MARQUES NUNES, MÔNICO-NETO, MARCOS, DE SÁ SOUZA, HELTON, DOS SANTOS QUARESMA, MARCUS VINÍCIUS LÚCIO, LEE, KIL SUN, UGRINOWITSCH, CARLOS, TUFIK, SERGIO, DE MELLO, MARCO TÚLIO·2020·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0000000000002137
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Abstract

Purpose: Sleep is considered essential for muscle recovery, mainly due to its effect on hormone secretion. Total sleep deprivation or restriction is known to alter not only blood hormones but also cytokines that might be related to skeletal muscle recovery. This study aimed to evaluate whether total sleep deprivation after eccentric exercise-induced muscle damage (EEIMD) modifies the profiles of blood hormones and cytokines. Methods: In two separate conditions, with a crossover and randomized model, 10 men (age, 24.5 ± 2.9 yr; body mass index, 22.7 ± 2.3 kg·m −2 ) performed a unilateral EEIMD protocol that comprised 240 eccentric contractions of the knee extensor muscles using an isokinetic dynamometer. In one condition, a “muscle damage” protocol was followed by 48 h of total sleep deprivation and 12 h of normal sleep (DEPRIVATION). In the other condition, the same muscle damage protocol was conducted, followed by three nights of regular sleep (SLEEP). Isometric muscle voluntary contraction tests and blood samples were collected serially throughout the protocol and analyzed for creatine kinase, free and total testosterone, IGF-1, cortisol, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, receptor antagonist of IL-1 and IL-10. Results: Muscle voluntary contraction and serum creatine kinase increased equally over the study period in both conditions. From the cytokines evaluated, only IL-6 increased in DEPRIVATION. No differences were detected in testosterone levels between conditions, but IGF-1, cortisol, and cortisol/total testosterone ratio were higher in DEPRIVATION. Conclusions: Total sleep deprivation after EEIMD does not delay muscle strength recovery but modifies inflammatory and hormonal responses.

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Crossref · 10.1249/mss.0000000000002137

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  • Sleep loss and lower sleep duration are associated with lower morning, afternoon, and 24-h testosterone.

    “When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosterone; as well as higher afternoon, but not morning or 24-h cortisol.”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [42]

  • Only 3 studies have examined 24-h testosterone, and of these, one was confounded by strenuous exercise.

    “Another limitation is that only 3 studies have examined 24-h testosterone, and of these, one [42] was confounded by strenuous exercise, which is known to increase testosterone [52].”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [42]

  • All in-laboratory studies when collectively examined show that sleep restriction decreases testosterone.

    “All studies when collectively examined show that sleep restriction decreases testosterone.”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [42]

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Research works printed but not linked: 37

  1. 1993, Effects of sleep deprivation and exercise on glucose tolerance, Aviat Space Environ Med, 64, 487
  2. 2015, Changes in plasma lipids during exposure to total sleep deprivation, Sleep, 38, 1683, 10.5665/sleep.5142 · DOI
  3. 2014, A review of evidence for the link between sleep duration and hypertension, Am J Hypertens, 27, 1235, 10.1093/ajh/hpu071 · DOI · Paper page
  4. 2007, Sleep deprivation and energy metabolism: to sleep, perchance to eat?, Curr Opin Endocrinol Diabetes Obes, 14, 374, 10.1097/MED.0b013e3282be9093 · DOI
  5. 2007, Exercise, sleep and cytokines: is there a relation?, Sleep Med Rev, 11, 231, 10.1016/j.smrv.2007.03.003 · DOI
  6. 1989, Sleep deprivation and the effect on exercise performance, Sports Med, 7, 235, 10.2165/00007256-198907040-00002 · DOI
  7. 2015, Sleep and athletic performance: the effects of sleep loss on exercise performance, and physiological and cognitive responses to exercise, Sports Med, 45, 161, 10.1007/s40279-014-0260-0 · DOI
  8. 2011, Sleep and muscle recovery: endocrinological and molecular basis for a new and promising hypothesis, Med Hypotheses, 77, 220, 10.1016/j.mehy.2011.04.017 · DOI · Paper page
  9. 2016, Leucine supplementation is anti-atrophic during paradoxical sleep deprivation in rats, Amino Acids, 48, 949, 10.1007/s00726-015-2142-7 · DOI
  10. 2017, REM sleep deprivation impairs muscle regeneration in rats, Growth Factors, 35, 12, 10.1080/08977194.2017.1314277 · DOI
  11. 2017, One night of sleep restriction following heavy exercise impairs 3-km cycling time-trial performance in the morning, Appl Physiol Nutr Metab, 42, 909, 10.1139/apnm-2016-0698 · DOI
  12. 2017, One night of partial sleep deprivation impairs recovery from a single exercise training session, Eur J Appl Physiol, 117, 699, 10.1007/s00421-017-3565-5 · DOI
  13. 2004, Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats, Am J Physiol Endocrinol Metab, 286, E1060, 10.1152/ajpendo.00553.2003 · DOI
  14. 2002, Contraction-induced muscle damage is unaffected by vitamin E supplementation, Med Sci Sports Exerc, 34, 798, 10.1097/00005768-200205000-00012 · DOI
  15. 2001, Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications, J Physiol, 537, 333
  16. 2001, Serum creatine kinase level is a poor predictor of muscle function after injury, Scand J Med Sci Sports, 11, 126, 10.1034/j.1600-0838.2001.011002126.x · DOI
  17. 2016, Susceptibility to exercise-induced muscle damage: a cluster analysis with a large sample, Int J Sports Med, 37, 633, 10.1055/s-0042-100281 · DOI
  18. 2012, Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?, Exerc Immunol Rev, 18, 42
  19. 2013, Salivary biomarkers of physical fatigue as markers of sleep deprivation, J Clin Sleep Med, 9, 1325, 10.5664/jcsm.3280 · DOI
  20. 2010, Consequences of sleep deprivation, Int J Occup Med Environ Health, 23, 95
  21. 2006, Phosphatidylserine supplementation and recovery following downhill running, Med Sci Sports Exerc, 38, 1617, 10.1249/01.mss.0000229459.11452.a0 · DOI
  22. 2003, A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males, Med Sci Sports Exerc, 35, 2032, 10.1249/01.MSS.0000099112.32342.10 · DOI
  23. 2002, Cytokine response to eccentric exercise in young and elderly humans, Am J Physiol Cell Physiol, 283, C289, 10.1152/ajpcell.00583.2001 · DOI
  24. 2010, Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury, J Interferon Cytokine Res, 30, 329, 10.1089/jir.2009.0079 · DOI
  25. 2005, Delayed leukocytosis and cytokine response to high-force eccentric exercise, Med Sci Sports Exerc, 37, 1877, 10.1249/01.mss.0000177064.65927.98 · DOI
  26. 2003, Interleukin-6 expression after repeated bouts of eccentric exercise, Int J Sports Med, 24, 15, 10.1055/s-2003-37197 · DOI
  27. 1999, Effects of training on exercise-induced muscle damage and interleukin 6 production, Muscle Nerve, 22, 208, 10.1002/(SICI)1097-4598(199902)22:2<208::AID-MUS8>3.0.CO;2-B · DOI
  28. 2001, Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight, J Allergy Clin Immunol, 107, 165, 10.1067/mai.2001.112270 · DOI · Paper page
  29. 2014, Role of interleukin-6 in cachexia: therapeutic implications, Curr Opin Support Palliat Care, 8, 321, 10.1097/SPC.0000000000000091 · DOI
  30. 2011, Sports-related injuries in youth athletes: is overscheduling a risk factor?, Clin J Sport Med, 21, 307, 10.1097/JSM.0b013e3182218f71 · DOI
  31. 2000, Adaptation of the 24-h growth hormone profile to a state of sleep debt, Am J Physiol Regul Integr Comp Physiol, 279, R874, 10.1152/ajpregu.2000.279.3.R874 · DOI · Paper page
  32. 2000, Effect of sleep deprivation on overall 24 h growth-hormone secretion, Lancet, 356, 1408, 10.1016/S0140-6736(00)02847-6 · DOI
  33. 2015, Vascular response to 1 week of sleep restriction in healthy subjects. A metabolic response?, Int J Cardiol, 190, 246, 10.1016/j.ijcard.2015.04.119 · DOI
  34. 2013, Pituitary-gonadal and pituitary-thyroid axis hormone concentrations before and during a hypoglycemic clamp after sleep deprivation in healthy men, PLoS One, 8, e54209, 10.1371/journal.pone.0054209 · DOI
  35. 2011, Disturbed glucoregulatory response to food intake after moderate sleep restriction, Sleep, 34, 371, 10.1093/sleep/34.3.371 · DOI · Paper page
  36. 2002, Role of interleukin-6 in stress response in normal and tumorous adrenal cells and during chronic inflammation, Ann N Y Acad Sci, 966, 304, 10.1111/j.1749-6632.2002.tb04230.x · DOI
  37. 1995, Blood hormones as markers of training stress and overtraining, Sports Med, 20, 251, 10.2165/00007256-199520040-00004 · DOI · Paper page

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Metadata

Authors
DÁTTILO, M., ANTUNES, H. K. M., GALBES, N. M. N., MÔNICO-NETO, M., DE SÁ SOUZA, H., DOS SANTOS QUARESMA, M. V. L., LEE, K. S., UGRINOWITSCH, C., TUFIK, S., & DE MELLO, M. T.
Affiliations
  • Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, BRAZIL
  • Universidade Federal de São Paulo (BR)
  • Universidade de São Paulo (BR)
  • Universidade Federal de Minas Gerais (BR)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-08-30
Volume
52
Issue
2
Pages
507-514
ISSN
  • 0195-9131 (ISSN-L)
  • 1530-0315
DOI
10.1249/mss.0000000000002137
OpenAlex
W2970397035
Cited by
75
References
12
Citations by year
2026: 6 · 2025: 17 · 2024: 19 · 2023: 7 · 2022: 8 · 2021: 12 · 2020: 5
FWCI
4.38
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
sleep deprivation, skeletal muscle recovery, cytokines, inflammation, testosterone, insulin-like growth factor I, cortisol, interleukin-6, creatine kinase, muscle strength, knee extensors
MeSH terms
Adult, Creatine Kinase, Humans, Hydrocortisone, Knee, Male, Muscle Contraction, Sleep Deprivation, Testosterone, Tumor Necrosis Factor-alpha, Exercise, Muscle, Skeletal, Cross-Over Studies, Receptors, Interleukin-6, Muscle Strength, Young Adult

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