CoChat
Sign Up
Cited by 183Sleep and Wakefulness ResearchGrowth Hormone and Insulin-like Growth FactorsSleep and Work-Related Fatigue

Adaptation of the 24-h growth hormone profile to a state of sleep debt

Spiegel, K., Leproult, R., Colecchia, E. F., L'Hermite-Balériaux, M., Nie, Z., Copinschi, G., Van Cauter, E.·2000·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.2000.279.3.r874
Open this paper in CoChat — free account

Abstract

In normal men, the majority of GH secretion occurs in a single large postsleep onset pulse that is suppressed during total sleep deprivation. We examined the impact of semichronic partial sleep loss, a highly prevalent condition, on the 24-h growth hormone profile. Eleven young men were studied after six nights of restricted bedtimes (0100-0500) and after 7 nights of extended bedtimes (2100-0900). Slow-wave sleep (SWS) was estimated as the duration of stages III and IV. Slow-wave activity (SWA) was calculated as electroencephalogram power density in the 0.5- to 3-Hz frequency range. During the state of sleep debt, the GH secretory pattern was biphasic, with both a presleep onset "circadian" pulse and a postsleep onset pulse. Postsleep onset GH secretion was negatively related to presleep onset secretion and tended to be positively correlated with the amount of concomitant SWA. When sleep was restricted, both SWS and SWA were increased during early sleep. Unexpectedly, the increase in SWA affected the second, rather than the first, SWA cycle, suggesting that presleep onset GH secretion may have limited SWA in the first cycle, possibly via an inhibition of central GH-releasing hormone activity. Thus neither the GH profile nor the distribution of SWA conformed with predictions from acute sleep deprivation studies, indicating that adaptation mechanisms are operative during chronic partial sleep loss.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.2000.279.3.r874

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Glucose effectiveness was 30% lower in the state of sleep debt.

    “SG was 30% lower in the state of sleep debt.”

    From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [18]

  • Acute insulin response to glucose was reduced by more than 30% after sleep restriction despite a trend for decreased insulin sensitivity.

    “AIRg was reduced by more than 30% after sleep restriction despite a trend for decreased SI.”

    From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [18]

  • In the first partial sleep deprivation study, glucose tolerance was lower in the sleep-debt condition than in the fully rested condition.

    “Glucose tolerance, assessed during an intravenous glucose tolerance test (ivGTT) and a high-carbohydrate breakfast, was lower in the sleep-debt condition than in the fully rested condition.”

    From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [18]

  • Partial and total sleep deprivation cause delay and/or reduction in cortisol acrophase.

    “In addition, a delay and/or a reduction in the acrophase of cortisol have been reported after partial and total sleep deprivation.95,102,109”

    From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [102]

  • Partial sleep deprivation does not affect 24-hour GH levels in lean or obese individuals, but six 4-hour nights change GH nocturnal secretory patterns to a biphasic pattern.

    “Partial sleep deprivation did not affect 24-h levels of GH in lean or obese individuals,101,109,118 but six 4-h nights changed GH nocturnal secretory patterns: sleep deprivation was associated with a biphasic pattern compared to the usual single large GH peak at sleep onset.102”

    From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [102]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Spiegel, K., Leproult, R., Colecchia, E. F., L'Hermite-Balériaux, M., Nie, Z., Copinschi, G., & Van Cauter, E.
Affiliations
  • Université Libre de Bruxelles (BE)
  • University of Chicago (US)
  • Center for Biological Rhythms and Laboratory of Experimental Medicine, Université Libre de Bruxelles, B-1070 Brussels, Belgium
  • Department of Medicine, University of Chicago, Chicago, Illinois 60637; and
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2000-09-01
Volume
279
Issue
3
Pages
R874-R883
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.2000.279.3.r874
OpenAlex
W1864579685
Cited by
183
References
39
Citations by year
2026: 2 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 9 · 2012: 12
FWCI
2.08
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-41814, R01DK041814)
  • National Center for Research Resources (M01RR000055, MO1 RR-00055)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
growth hormone secretion, sleep debt, sleep restriction, slow-wave sleep, slow-wave activity, circadian rhythm, growth hormone-releasing hormone
MeSH terms
Adaptation, Physiological, Adult, Circadian Rhythm, Electroencephalography, Humans, Male, Sleep, Sleep Deprivation, Linear Models, Human Growth Hormone, Sleep Disorders, Circadian Rhythm

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review