Cited by 193Exercise and Physiological ResponsesHerbal Medicine Research StudiesCardiovascular and exercise physiology

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Quercetin Reduces Illness but Not Immune Perturbations after Intensive Exercise

NIEMAN, DAVID C., HENSON, DRU A., GROSS, SARAH J., JENKINS, DAVID P., DAVIS, J. MARK, MURPHY, E. ANGELA, CARMICHAEL, MARTIN D., DUMKE, CHARLES L., UTTER, ALAN C., MCANULTY, STEVEN R., MCANULTY, LISA S., MAYER, EUGENE P.·2007·Medicine & Science in Sports & Exercise

DOI 10.1249/mss.0b013e318076b566

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Abstract

PURPOSE: To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections (URTI) and exercise-induced changes in immune function. METHODS: Trained male cyclists (N=40) were randomized to quercetin (N=20) or placebo (N=20) groups and, under double-blind procedures, received 3 wk quercetin (1000 mg.d(-1)) or placebo before, during, and for 2 wk after a 3-d period in which subjects cycled for 3 h.d(-1) at approximately 57% Wmax. Blood and saliva samples were collected before and after each of the three exercise sessions and assayed for natural killer cell activity (NKCA), PHA-stimulated lymphocyte proliferation (PHA-LP), polymorphonuclear oxidative-burst activity (POBA), and salivary IgA output (sIgA). RESULTS: Pre- to postexercise changes in NKCA, PHA-LP, POBA, and sIgA did not differ significantly between quercetin and placebo groups. URTI incidence during the 2-wk postexercise period differed significantly between groups (quercetin=1/20 vs placebo=9/20, Kaplan-Meier analysis statistic=8.31, P=0.004). CONCLUSION: Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced URTI incidence in cyclists during the 2-wk period after intensified exercise.

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Result
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You Asked For It
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Nonalcoholic Beer Reduces Inflammation and Incidence of Respiratory Tract Illness
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Immune Response in Young Men to the 2014/15 Seasonal Influenza Vaccine
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Energy Demands for Endurance Athletes
Mendel, R. W. (2012) · CRC Press eBooks · doi:10.1201/b11808-5
Exercise, Nutrition, and Immune Function
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Self-citation
Effect Of Quercetin And Epigallocatechin-3-Gallate On Anti-inflammatory Activity In Vitro And In Vivo
Kennerly, K. (2017) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) · doi:10.71889/5fylantbak.29861930
Effect of antioxidant supplement on performance in rowers
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Everyone is an “Athlete”
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Effects of dietary quercetin supplementation on physical performance, mood, sleep, and illness during military physical training
Bigelman, K. A. (2009)
The effects of quercetin on skeletal muscle mitochondrial biogenesis and OXPHOS regulation
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“This group also had a significantly reduced incidence rate of upper respiratory tract infection during the two weeks following a 3-day period of intense exercise, despite no changes in immune function (Nieman et al., 2007).”
Background
Thème 3. L’immunonutrition pour les sportifs : est-ce que ça marche ?
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Self-citation
Topic 3. Immunonutrition support for athletes: does it work?
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Self-citation
Effect of varied tapering on the immune cells of endurance athletes in some selected training centers of Ethiopia
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BackgroundInfluential
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POLİFENOLLERİN SAĞLIK VE SPOR PERFORMANSINA ETKİLERİ
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You Asked for It
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Saúde Contemporânea e Evidências Científicas
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“In a smaller exercise-stress model, quercetin reduced post-exercise URTI incidence in cyclists, with illness reported in 1 of 20 participants in the quercetin arm versus 9 of 20 in placebo [5].”
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Authors: NIEMAN, D. C., HENSON, D. A., GROSS, S. J., JENKINS, D. P., DAVIS, J. M., MURPHY, E. A., CARMICHAEL, M. D., DUMKE, C. L., UTTER, A. C., MCANULTY, S. R., MCANULTY, L. S., & MAYER, E. P.
Affiliations: Appalachian State University (US)
ORCID: NIEMAN, DAVID C.
MURPHY, E. ANGELA
DUMKE, CHARLES L.
MCANULTY, STEVEN R.
Venue: Medicine & Science in Sports & Exercise
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-09
Volume: 39
Issue: 9
Pages: 1561-1569
ISSN: 0195-9131 (ISSN-L)
DOI: 10.1249/mss.0b013e318076b566
OpenAlex: W2100065198
Cited by: 193
References: 35
Citations by year: 2026: 4 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 15 · 2020: 13 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 12 · 2013: 20 · 2012: 12
FWCI: 13.34
Type: journal article
Language: en
Open access: closed
Locations: Medicine & Science in Sports & Exercise (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Complementary and alternative medicine › Herbal Medicine Research Studies
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: quercetin, upper respiratory tract infection, exercise immunology, NK cell cytotoxicity, lymphocyte proliferation, neutrophil respiratory burst, salivary IgA, antioxidant supplementation, cyclists, disease incidence
MeSH terms: Adult, Antioxidants, Physical Exertion, Humans, Immune System, Killer Cells, Natural, Male, Peroxidase, Neutrophils, Quercetin, Respiratory Tract Infections, T-Lymphocytes, Exercise

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Quercetin Reduces Illness but Not Immune Perturbations after Intensive Exercise

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