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Cited by 29Muscle metabolism and nutritionCardiovascular and exercise physiologySports Performance and Training

Exogenous Carbohydrate Spares Muscle Glycogen in Men and Women during 10 h of Exercise

HARGER-DOMITROVICH, STEPHANIE G., McCLAUGHRY, ANNE E., GASKILL, STEVEN E., RUBY, BRENT C.·2007·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0b013e318157a650
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Abstract

PURPOSE: The purpose of the study was to evaluate the effects of carbohydrate (CHO) supplementation on whole-body and net muscle substrate use during 10 h of discontinuous exercise, simulating occupational settings in men and women. METHODOLOGY: Recreationally trained subjects (N = 7 males, N = 6 females) performed a graded exercise test on a treadmill (TM) and cycle ergometer (CE) to determine ventilatory threshold (VT) and V O2peak. In a double-blind, randomized crossover design, subjects received either CHO [20% maltodextrin (0.6 g.kg FFM.h)] or flavored placebo (PLA) drink each hour across 10 h of exercise. Exercise intensity was 71.3 +/- 3% and 72.4 +/- 4% VT for TM and CE, respectively. Hourly exercise included 9 min of upper-body ergometery, 19 min of cycling, and 20 min of treadmill walking, with a 1-min transition between modes, followed by a 10-min rest and feeding period. The protocol was selected to simulate arduous occupational settings. Vastus lateralis biopsies were obtained before and after exercise. Expired gases were collected every other hour to establish average rates of whole-body CHO and fat oxidation. Blood glucose (BG) was measured continuously. RESULTS: Whole-body CHO oxidation was maintained during CHO trial compared with the PLA trial. Net muscle glycogen use was 52% higher for the PLA trial (176.0 +/- 16.7, 117.0 +/- 20.9 and 164.5 +/- 11.0, 133.8 +/- 10.9 mmol.kg w.w. for PLA and CHO, respectively, P < 0.05). There were no significant sex-specific differences in glycogen use, whole-body substrate oxidation, or BG values. CONCLUSION: The ingestion of CHO during long-duration exercise decreases net muscle glycogen use while better maintaining whole-body carbohydrate oxidation, and potentially increasing performance in field settings. There are limited differences in sex-specific substrate oxidation.

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  • Some research indicates that substrate use sex differences are eliminated when subjects exercise in a fed as opposed to fasted state.

    “Some research indicates that substrate use sex differences are eliminated when subjects exercise in a fed as opposed to fasted state (Harger-Domitrovich et al. 2007).”

    From Males and females exhibit similar muscle glycogen recovery with varied recovery food sources (2020) · cites this paper as Harger-Domitrovich et al. 2007

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Authors
HARGER-DOMITROVICH, S. G., McCLAUGHRY, A. E., GASKILL, S. E., & RUBY, B. C.
Affiliations
University of Montana (US)
ORCID
RUBY, BRENT C.
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-12
Volume
39
Issue
12
Pages
2171-2179
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/mss.0b013e318157a650
OpenAlex
W2083236628
Cited by
29
References
39
Citations by year
2026: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
carbohydrate supplementation, muscle glycogen, prolonged exercise, maltodextrin, substrate oxidation, fat oxidation, blood glucose, sex differences, endurance performance, vastus lateralis
MeSH terms
Adult, Carbohydrates, Energy Metabolism, Female, Glycogen, Humans, Male, Time Factors, Exercise, Muscle, Skeletal, Cross-Over Studies, Carbohydrate Metabolism, Lipid Metabolism

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