Cited by 73Tea Polyphenols and EffectsNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers

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Oyama, Jun-ichi, Maeda, Toyoki, Kouzuma, Kazuya, Ochiai, Ryuji, Tokimitsu, Ichiro, Higuchi, Yoshihiro, Sugano, Masahiro, Makino, Naoki·2010·Circulation Journal

Abstract

BACKGROUND: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. METHODS AND RESULTS: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. CONCLUSIONS: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.

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Crossref · 10.1253/circj.cj-09-0692

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  • In a clinical trial, subjects drinking three cups of green tea for a period of four months restored endothelial dysfunction and reduced 8-iso-prostoglandin-F2α.

    “In a clinical trial, it has been reported that subjects drinking three cups of green tea for a period of four months have restored endothelial dysfunction and reduced 8-iso-prostoglandin-F2α, a useful oxidative stress marker.”

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Research works printed but not linked: 2

  1. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, et al. Increase in circulating products of lipid peroxidation (F2- isoprostanes) in smokers. N Engl J Med 1995; 332: 1198 -1203.
  2. Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol 2000; 20: 2032 -2037.

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Authors
Oyama, J.-I., Maeda, T., Kouzuma, K., Ochiai, R., Tokimitsu, I., Higuchi, Y., Sugano, M., & Makino, N.
Affiliations
  • Kyushu University Hospital (JP)
  • Kao Corporation (Japan) (JP)
Venue
Circulation Journal
Published
2010
Volume
74
Issue
3
Pages
578-588
ISSN
  • 1346-9843 (ISSN-L)
  • 1347-4820
OpenAlex
W2028211052
Cited by
73
References
39
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 14
FWCI
4.56
Type
journal article
Language
en
Open access
Locations
  • Circulation Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
green tea catechins, endothelial dysfunction, smokers, forearm blood flow, acetylcholine-induced vasodilation, nitric oxide, oxidative stress, asymmetric dimethylarginine, malondialdehyde, 4-hydroxynonenal, C-reactive protein, MCP-1, soluble CD40 ligand, atherosclerosis, cardiovascular risk
MeSH terms
Acetylcholine, Adult, Arginine, C-Reactive Protein, Catechin, Endothelium, Vascular, Forearm, Humans, Male, Malondialdehyde, Nitroprusside, Plant Extracts, Smoking, Tea, Vasodilation, Vasodilator Agents, Oxidative Stress, Chemokine CCL2, CD40 Ligand, Atherosclerosis

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