Tea and cardiovascular disease

Deka, Apranta; Vita, Joseph A.

doi:10.1016/j.phrs.2011.03.009

Cited by 184Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

Tea and cardiovascular disease

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Deka, Apranta, Vita, Joseph A.·2011·Pharmacological Research

DOI 10.1016/j.phrs.2011.03.009PMC PMC3123419

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Abstract

There is increasing evidence for a protective effect of tea consumption against cardiovascular disease. This review summarizes the available epidemiological data providing evidence for and against such an effect. We also review observational and intervention studies that investigated an effect of tea and tea extracts on cardiovascular risk factors, including blood pressure, serum lipids, diabetes mellitus, and obesity. Finally, we review potential mechanisms of benefit, including anti-inflammatory, anti-oxidant, and anti-proliferative effects, as well as favorable effects on endothelial function. Overall, the observational data suggest a benefit, but results are mixed and likely confounded by lifestyle and background dietary factors. The weight of evidence indicates favorable effects on risk factors and a number of plausible mechanisms have been elucidated in experimental and translational human studies. Despite the growing body evidence, it remains uncertain whether tea consumption should be recommended to the general population or to patients as a strategy to reduce cardiovascular risk.

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Consumption of L-THE is associated with antihypertensive properties.
“In addition, the consumption of L-THE is associated with antihypertensive [12,13], anti-inflammatory properties [8] as well as improvements in cognitive functioning in healthy adults [14] and when consumed in combination with caffeine [10].”
From The Effect of L-Theanine Incorporated in a Functional Food Product (Mango Sorbet) on Physiological Responses in Healthy Males: A Pilot Randomised Controlled Trial (2020) · cites this paper as [12]

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Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works
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Cranberries and Their Bioactive Constituents in Human Health
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Habauzit, V., & Morand, C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311430006 · Cited by 260 · see citing works
Nutritional Recommendations for Cardiovascular Disease Prevention
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Prevention of Chronic Diseases by Tea: Possible Mechanisms and Human Relevance
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Green and black tea for the primary prevention of cardiovascular disease
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Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders
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Anti-hypertensive Herbs and their Mechanisms of Action: Part I
Disi, S. S. A., Anwar, M. A., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00323 · Cited by 163 · see citing works
Effects of tea and coffee on cardiovascular disease risk
Bøhn, S. K., Ward, N. C., Hodgson, J. M., & Croft, K. D. (2012) · Food & Function · doi:10.1039/c2fo10288a · Cited by 161 · see citing works
Tea consumption and disease correlations
Şanlıer, N., Gökcen, B. B., & Altuğ, M. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.05.026 · Cited by 155 · see citing works
Potential role of green tea catechins in various disease therapies: Progress and promise
Mak, J. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05673.x · Cited by 145 · see citing works
Antioxidant activity of different white teas: Comparison of hot and cold tea infusions
Damiani, E., Bacchetti, T., Padella, L., Tiano, L., & Carloni, P. (2013) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2013.09.010 · Cited by 144 · see citing works
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
Anwar, M. A., Disi, S. S. A., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00050 · Cited by 140 · see citing works
Studies on prevention of obesity, metabolic syndrome, diabetes, cardiovascular diseases and cancer by tea
Yang, C. S., Wang, H., & Sheridan, Z. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2017.10.010 · Cited by 137 · see citing works
Bioactive procyanidins from dietary sources: The relationship between bioactivity and polymerization degree
Yang, H., Tuo, X., Wang, L., Tundis, R., Portillo, M. P., Simal‐Gándara, J., Yu, Y., Zou, L., Xiao, J., & Deng, J. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.063 · Cited by 136 · see citing works
Cytochrome P450 enzyme mediated herbal drug interactions (Part 2).
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Plants Used as Antihypertensive
Verma, T., Sinha, M. D., Bansal, N., Yadav, S. R., Shah, K., & Chauhan, N. S. (2020) · Natural Products and Bioprospecting · doi:10.1007/s13659-020-00281-x · Cited by 124 · see citing works
Polyphenols and the Human Brain: Plant “Secondary Metabolite” Ecologic Roles and Endogenous Signaling Functions Drive Benefits
Kennedy, D. O. (2014) · Advances in Nutrition · doi:10.3945/an.114.006320 · Cited by 125 · see citing works
Recent developments of green analytical techniques in analysis of tea's quality and nutrition
Chen, Q., Zhang, D., Pan, W., Ouyang, Q., Li, H., Urmila, K. S., & Zhao, J. (2015) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2015.01.009 · Cited by 120 · see citing works
Epigallocatechin-3-gallate prevents cardiac apoptosis by modulating the intrinsic apoptotic pathway in isoproterenol-induced myocardial infarction
Othman, A. I., Elkomy, M. M. A., El-Missiry, M. A., & Dardor, M. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.014 · Cited by 120 · see citing works
Recent Scientific Studies of a Traditional Chinese Medicine, Tea, on Prevention of Chronic Diseases
Yang, C. S., Chen, G., & Wu, Q. (2014) · Journal of Traditional and Complementary Medicine · doi:10.4103/2225-4110.124326 · Cited by 111 · see citing works
Tea and human health: biomedical functions of tea active components and current issues
Chen, Z., & Lin, Z. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500001 · Cited by 104 · see citing works
Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model
Xie, Y., Kosińska, A., Xu, H., & Andlauer, W. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.063 · Cited by 100 · see citing works
Efficient extraction strategies of tea (Camellia sinensis) biomolecules
Banerjee, S., & Chatterjee, J. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-014-1487-3 · Cited by 96 · see citing works
Lipophilization of EGCG and effects on antioxidant activities
Liu, B., & Yan, W. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2018.08.086 · Cited by 96 · see citing works
Trends of tea in cardiovascular health and disease: A critical review
Fang, J., Sureda, A., Sanches-Silva, A. T., Khan, F., Xu, S., & Nabavi, S. M. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.04.001 · Cited by 91 · see citing works
Extraction Kinetics of phytochemicals and antioxidant activity during black tea (Camellia sinensis L.) brewing
Fernando, C. D., & Soysa, P. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0060-x · Cited by 89 · see citing works
Effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials
Liu, G., Mi, X.-N., Zheng, X.-X., Xu, Y.-L., Lu, J., & Huang, X.-H. (2014) · British Journal of Nutrition · doi:10.1017/s0007114514001731 · Cited by 85 · see citing works
Studies on the Prevention of Cancer and Cardiometabolic Diseases by Tea: Issues on Mechanisms, Effective Doses, and Toxicities
Yang, C. S., & Zhang, J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05242 · Cited by 82 · see citing works
Synergistic, antagonistic and additive interactions of green tea polyphenols
Colon, M., & Nerı́n, C. (2015) · European Food Research and Technology · doi:10.1007/s00217-015-2532-9 · Cited by 79 · see citing works
The beneficial health effects of green tea amino acid <scp>l</scp>‐theanine in animal models: Promises and prospects for human trials
Williams, J., Sergi, D., McKune, A. J., Georgousopoulou, E. N., Mellor, D. D., & Naumovski, N. (2019) · Phytotherapy Research · doi:10.1002/ptr.6277 · Cited by 73 · see citing works
Cellular targets for the beneficial actions of tea polyphenols
Lorenz, M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058230 · Cited by 73 · see citing works
Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis
Negri, S., Faris, P. S., Rosti, V., Antognazza, M. R., Lodola, F., & Moccia, F. D. (2020) · Cells · doi:10.3390/cells9061341 · Cited by 67 · see citing works
Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications
Mukherjee, P. K., Efferth, T., Das, B., Kar, A., Ghosh, S., Singha, S., Debnath, P., Sharma, N., Bhardwaj, P. K., & Haldar, P. K. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153930 · Cited by 65 · see citing works
Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence
Tomé‐Carneiro, J., & Visioli, F. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01243-7 · Cited by 69 · see citing works
Effect of green tea supplementation on blood pressure among overweight and obese adults
Li, G., Zhang, Y., Thabane, L., Mbuagbaw, L. C. E., Liu, A., Levine, M., & Holbrook, A. M. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000426 · Cited by 61 · see citing works
Chronic ( − )-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats
Gómez‐Guzmán, M., Jiménez, R., Sánchez, M., Romero, M., O’Valle, F., López-Sepúlveda, R., Quintela, A. M., Galindo, P., Zarzuelo-Romero, M. J., Bailón, E., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004314 · Cited by 60 · see citing works
Cacao liquor procyanidin extract improves glucose tolerance by enhancing GLUT4 translocation and glucose uptake in skeletal muscle
Yamashita, Y., Okabe, M., Natsume, M., & Ashida, H. (2012) · Journal of Nutritional Science · doi:10.1017/jns.2012.2 · Cited by 59 · see citing works
The effects of green tea polyphenols on drug metabolism
Yang, C. S., & Pan, E. Y. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.681375 · Cited by 59 · see citing works
l-Theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation
Siamwala, J. H., Dias, P. M., Majumder, S., Joshi, M. K., Sinkar, V. P., Banerjee, G., & Chatterjee, S. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.02.016 · Cited by 58 · see citing works
Diabetes and Alzheimer’s Disease: Can Tea Phytochemicals Play a Role in Prevention?
Fernando, W. M. A. D. B., Somaratne, G., Goozee, K. G., Williams, S., Singh, H., & Martins, R. N. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161200 · Cited by 55 · see citing works
Rapid analysis of hypolipidemic drugs in a live zebrafish assay
Zhou, J., Xu, Y.-Q., Guo, S., & Li, C. (2014) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.12.002 · Cited by 56 · see citing works
Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance
Kennedy, D. O. (2019) · Sports Medicine · doi:10.1007/s40279-018-1007-0 · Cited by 58 · see citing works
Epigallocatechin gallate: a review
Bartošíková, L., & Nečas, J. (2018) · Veterinární Medicína · doi:10.17221/31/2018-vetmed · Cited by 52 · see citing works
The therapeutic potential of matcha tea: A critical review on human and animal studies
Sokary, S., Al‐Asmakh, M., Zakaria, Z. Z., & Bawadi, H. A. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.11.015 · Cited by 62 · see citing works
Estimated assessment of cumulative dietary exposure to organophosphorus residues from tea infusion in China
Cao, P., Yang, D., Zhu, J., Liu, Z., Jiang, D., & Xu, H. (2018) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-018-0696-1 · Cited by 50 · see citing works
The hypoglycemic effects of guava leaf (Psidium guajava L.) extract are associated with improving endothelial dysfunction in mice with diet-induced obesity
Díaz-de-Cerio, E., Rodríguez-Nogales, A., Algieri, F., Romero, M., Verardo, V., Segura-Carretero, A., Duarte, J., & Galvez, J. (2017) · Food Research International · doi:10.1016/j.foodres.2017.03.019 · Cited by 47 · see citing works
Green and black tea for the primary prevention of cardiovascular disease
Hartley, L., Flowers, N., Clarke, A., Stranges, S., Hooper, L., & Rees, K. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009934 · Cited by 46 · see citing works
Effects of black tea on body composition and metabolic outcomes related to cardiovascular disease risk: a randomized controlled trial
Bøhn, S. K., Croft, K. D., Burrows, S., Puddey, I. B., MULDER, T. P. J., Fuchs, D., Woodman, R. J., & Hodgson, J. M. (2014) · Food & Function · doi:10.1039/c4fo00209a · Cited by 45 · see citing works
Effect of particle size on the bioaccessibility of polyphenols and polysaccharides in green tea powder and its antioxidant activity after simulated human digestion
Shu, Y., Li, J., Yang, X., Dong, X., & Wang, X. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-03573-4 · Cited by 44 · see citing works
Capsule shell material impacts the in vitro disintegration and dissolution behaviour of a green tea extract
Glube, N. D., von Moos, L. M. E., & Duchateau, G. S. M. J. E. (2013) · Results in Pharma Sciences · doi:10.1016/j.rinphs.2013.08.002 · Cited by 44 · see citing works
Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors
Rivero-Buceta, E. M., Carrero, P., Doyagüez, E. G., Madrona, A., Quesada, E., Camarasa, M., Pérez‐Pérez, M., Leyssen, P., Paeshuyse, J., Balzarini, J. M., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.033 · Cited by 42 · see citing works
Determination of plasticizer residues in tea by solid phase extraction–gas chromatography–mass spectrometry
Turco, V. L., Bella, G. D., Potortì, A. G., Fede, M. R., & Dugo, G. (2014) · European Food Research and Technology · doi:10.1007/s00217-014-2344-3 · Cited by 40 · see citing works
The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome
Simão, A. N. C., Lozovoy, M. A. B., & Dichi, I. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.723694 · Cited by 40 · see citing works
Treat to target in axial spondyloarthritis: From its concept to its implementation
Dougados, M. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102398 · Cited by 40 · see citing works
Bioactive compounds as an alternative for drug co-therapy: Overcoming challenges in cardiovascular disease prevention
Scolaro, B., Kim, H. S. J., & de Castro, I. A. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1235546 · Cited by 37 · see citing works
Tea in cardiovascular health and disease: a critical appraisal of the evidence
Lange, K. W. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.12.034 · Cited by 37 · see citing works
Evaluation of thrombin inhibitory activity of catechins by online capillary electrophoresis-based immobilized enzyme microreactor and molecular docking
Li, Q., Yang, F. Q., Wang, Y., Wu, Z., Xia, Z., & Chen, H. (2018) · Talanta · doi:10.1016/j.talanta.2018.03.049 · Cited by 36 · see citing works
Bioactive‐rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress
Danesi, F., Saha, S., Kroon, P. A., Glibetić, M., Konić‐Ristić, A., D’Antuono, L. F., & Bordoni, A. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6214 · Cited by 36 · see citing works
Effect of Black Tea Consumption on Blood Cholesterol: A Meta-Analysis of 15 Randomized Controlled Trials
Wang, D., Chen, C., Wang, Y., Liu, J., & Lin, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107711 · Cited by 35 · see citing works
A Study of Diet and Lifestyle and the Risk of Urolithiasis in 1,519 Patients in Southern China
Dong, Z., Li, M., Cheng, L., Zhang, J., Huang, H., & Yao, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.916703 · Cited by 34 · see citing works
Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet
Wu, M., Wu, X., Zhu, J., Li, F., Wei, X., & Wang, Y. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.12.031 · Cited by 34 · see citing works
GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats
Cherng, S., Huang, C., Kuo, W., Lai, S.-E., Tseng, C.-Y., Lin, Y.-M., Tsai, F., & Wang, H.-F. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.12.022 · Cited by 32 · see citing works
Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin
Novaković, A., Marinko, M., Vranić, A., Janković, G., Milojević, P. S., Stojanovic, I. C., Nenezić, D., Ugrešić, N. D., Kanjuh, V., Yang, Q., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.066 · Cited by 31 · see citing works
Transient receptor potential vanilloid type 1 is vital for (−)‐epigallocatechin‐3‐gallate mediated activation of endothelial nitric oxide synthase
Guo, B., Wei, J., Su, K., Chiang, A., Zhao, J., Chen, H., Shyue, S., & Lee, T. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400699 · Cited by 30 · see citing works
Plasma tea catechins and risk of cardiovascular disease in middle-aged Japanese subjects: The JPHC study
Ikeda, A., Iso, H., Yamagishi, K., Iwasaki, M., Yamaji, T., Miura, T., Sawada, N., Inoue, M., & Tsugane, S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.08.001 · Cited by 30 · see citing works
Blood pressure is associated with tea consumption: A cross-sectional study in a rural, elderly population of Jiangsu China
Yin, J., Duan, S., Liu, F.-C., Yao, Q.-K., Tu, S., Xu, Y., & Pan, C. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0829-4 · Cited by 28 · see citing works
Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
Tian, D., Kellogg, J. J., Okut, N., Oberlies, N. H., Cech, N. B., Shen, D. D., McCune, J. S., & Paine, M. F. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.079491 · Cited by 28 · see citing works
Oleaster Oil Positively Modulates Plasma Lipids in Humans
Belarbi, M., Bendimerad, S., Sour, S., Soualem, Z., Baghdad, C., Hmimed, S., Chemat, F., & Visioli, F. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201865z · Cited by 28 · see citing works
Phytochemicals, Anti‐Inflammatory, Antiproliferative, and Methylglyoxal Trapping Properties of Zijuan Tea
Gao, X., Ho, C., Li, X., Lin, X., Zhang, Y., Chen, Z., & Li, B. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14029 · Cited by 27 · see citing works
Use of herbal medication in the perioperative period: Potential adverse drug interactions
Elvir-Lazo, O. L., White, P. F., Lee, C., Eng, H. C., Matin, J. M., Lin, C., Cid, F. D., & Yumul, R. (2024) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2024.111473 · Cited by 26 · see citing works
Epigallocatechin-3-gallate inhibits angiotensin II-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9c2 rat cardiomyocytes
Ma, Y., Hu, Y., Wu, J., Wen, J., Li, S., Zhang, L., Zhang, J., Li, Y., & Li, J. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz018 · Cited by 26 · see citing works
Tea consumption and its effects on primary and secondary prevention of coronary artery disease: Qualitative synthesis of evidence from randomized controlled trials
Dludla, P. V., Nkambule, B. B., Mazibuko-Mbeje, S. E., Nyambuya, T. M., Orlando, P., Silvestri, S., Marcheggiani, F., Cirilli, I., Ziqubu, K., Ndevahoma, F., et al. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.11.006 · Cited by 26 · see citing works
Influence of flavonol-rich excipient food (onion peel and Dendropanax morbifera) on the bioavailability of green tea epicatechins in vitro and in vivo
Choi, E., Lee, D., Kim, S., Chung, J., Choi, J.-K., Joo, K., Jeong, H. W., Kim, J. K., Kim, W. G., & Shim, S. (2017) · Food & Function · doi:10.1039/c7fo01173c · Cited by 26 · see citing works
Antioxidants to enhance fertility: Role of eNOS and potential benefits
Visioli, F., & Hagen, T. M. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.06.021 · Cited by 25 · see citing works
Inhibitory Effect of Epigallocatechin Gallate on the Virulence of Clostridium difficile PCR Ribotype 027
Yun, B., Oh, S., Hong, Y., Hong, Y., Park, S., Park, D., Griffiths, M. W., & Oh, S. (2015) · Journal of Food Science · doi:10.1111/1750-3841.13145 · Cited by 25 · see citing works
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway
Cui, Y., Wang, Y., & Liu, G. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1972124 · Cited by 25 · see citing works
Galloyl moieties enhance the binding of (−)-epigallocatechin-3-gallate to β-lactoglobulin: A spectroscopic analysis
Zhang, L., Wang, Y., Xu, M., & Hu, X. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.048 · Cited by 25 · see citing works
UV‐C Irradiation on the Quality of Green Tea: Effect on Catechins, Antioxidant Activity, and Cytotoxicity
Vergne, M. J., Patras, A., Bhullar, M. S., Shade, L. M. P., Sasges, M. R., Rakariyatham, K., Pan, C., & Xiao, H. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14131 · Cited by 24 · see citing works
Systematic Analysis of Combined Antioxidant and Membrane-Stabilizing Properties of Several Lamiaceae Family Kazakhstani Plants for Potential Production of Tea Beverages
Ydyrys, A., Zhaparkulova, N., Aralbaeva, A. N., Mamataeva, А. Т., Seilkhan, A., Syraiyl, S., & Murzakhmetova, M. K. (2021) · Plants · doi:10.3390/plants10040666 · Cited by 34 · see citing works
Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
Logesh, R., Radhakrishnan, A., Alagarsamy, K. N., Srivastava, A., Dhingra, S., Booker, A., Rolfe, V., Palaniswamy, D. S., & Mohankumar, S. K. (2022) · PharmaNutrition · doi:10.1016/j.phanu.2022.100296 · Cited by 24 · see citing works
Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice
Mota, M. A. D. L., Landim, J. S. P., Targino, T. S. S., da Silva, S. F. R., da Silva, S. L., & Pereira, M. R. (2015) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020150040000002 · Cited by 23 · see citing works
L-Theanine: From Tea Leaf to Trending Supplement—Does the Science Match the Hype for Brain Health and Relaxation?
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Authors: Deka, A., & Vita, J. A.
Affiliations: Boston University (US)
Corresponding author: Vita, Joseph A.
ORCID: Vita, Joseph A.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2011-08
Volume: 64
Issue: 2
Pages: 136-145
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2011.03.009
PMC: PMC3123419
OpenAlex: W1966599364
Cited by: 184
References: 163
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 19 · 2013: 19 · 2012: 14
FWCI: 13.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
U.S. Food and Drug Administration
DSM Nutritional Products
National Heart, Lung, and Blood Institute (R01HL102299, HL081587, P50HL083801, HL083269, K12HL083781, P01HL081587, R01HL075795, HL75795, R01HL083269, HL083801, HL102299)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords: tea consumption, cardiovascular disease, cardiovascular risk factors, blood pressure, serum lipids, diabetes mellitus, obesity, anti-inflammatory activity, antioxidant activity, antiproliferative activity, endothelial function, tea extract, lifestyle confounding
MeSH terms: Animals, Cardiovascular Diseases, Humans, Risk Factors, Tea

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