Genetic Association of Short Sleep Duration With Hypertension Incidence: – A 6-Year Follow-up in the Korean Genome and Epidemiology Study –
Open accessAbstract
BACKGROUND: Hypertension (HT) is caused by complex interactions between genetic and environmental factors. Despite evidence for an association between short sleep duration and the development of HT, genetic factors associated with this effect have not been defined. Here we prospectively investigated the incidence of HT in subjects with short sleep duration over a 6-year follow-up period, and identified associated genetic variants in a genome-wide association study. METHODS AND RESULTS: Sleep duration was determined by questionnaire and 3 categories were established: <5h, 5-7h, and >7h. Genotyping was carried out using the Affymetrix Genome-Wide Human Single Nucleotide Polymorphism (SNP) Array 5.0. Of the 4,965 individuals included in our study, 1,071 (543 of 2,330 men, 528 of 2,635 women) developed HT. The cumulative incidence of HT during the 6-year study period was 21.6%. Sleep duration <5h was associated with an increased risk of incident HT only in premenopausal women (adjusted hazard ratio 2.43, 95% confidence interval 1.36-4.35). The SNPs of rs6691577, rs2226284 and rs12756253 were associated with this increased risk. CONCLUSIONS: This prospective communitywide study showed that premenopausal women with short sleep duration had an increased risk of incident HT, and found associations with specific genomic markers.
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Self-reported short and long sleep duration have been associated with hypertension.
“hypertension[2, 13, 14]”
From Habitual sleep duration associated with self-reported and objectively determined cardiometabolic risk factors (2014) · cites this paper as [14]
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“Both self-reported short and long sleep duration have been associated with elevated risk for obesity in children and adults [1–7], as well as cardiovascular disease [8–10], diabetes mellitus (DM) [4,11,12], hypertension [2,13,14], and other negative health outcomes [2,15–17] (i.”
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- Authors
- Kim, S. J., Lee, S. K., Kim, S. H., Yun, C.-H., Kim, J. H., Thomas, R. J., & Shin, C.
- Affiliations
- Korea University Ansan Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Beth Israel Deaconess Medical Center (US)
- ORCID
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2012
- Volume
- 76
- Issue
- 4
- Pages
- 907-913
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W1522008731
- Cited by
- 39
- References
- 52
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 7 · 2013: 7
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- short sleep duration, hypertension incidence, genetic susceptibility, single nucleotide polymorphisms, premenopausal women, sex differences
- MeSH terms
- Adult, Aged, Analysis of Variance, Female, Follow-Up Studies, Genetic Markers, Humans, Hypertension, Male, Middle Aged, Phenotype, Prospective Studies, Surveys and Questionnaires, Risk Factors, Sex Factors, Sleep, Time Factors, Incidence, Chi-Square Distribution, Proportional Hazards Models, Premenopause, Risk Assessment, Genetic Predisposition to Disease, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Gene Expression Profiling, Asian People, Genome-Wide Association Study, Republic of Korea
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